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Amgen’s Fourth Quarter 2010 Adjusted Earnings Per Share Increased 11 Percent to $1.17; Full Year 2010 Adjusted Earnings Per Share Increased 6 Percent to $5.21
Date:1/24/2011

on expense, certain expenses related to prior acquisitions and the non-cash interest expense resulting from a change in accounting for convertible debt.  

The total impact of U.S. health care reform in 2011 is expected to be in the range of $400 million to $500 million.  This includes the federal excise fee which is expected to be in the range of $150 million to $200 million.

With respect to other guidance, Amgen’s expectation for the 2011 adjusted tax rate is that it will be in the range of 19 percent to 20 percent.

The Company expects 2011 capital expenditures to be approximately $600 million.

Fourth Quarter Product and Pipeline UpdateIn addition to the previously announced U.S. approval of XGEVA and the top-line results from the pivotal Phase 3 study of XGEVA for the prevention of bone metastases in patients with prostate cancer (‘147 study) the Company provided the following updates:

Sensipar / Mimpara: The Company announced that based on current event rates, completion of the Phase 3 Evaluation of Cinacalcet Therapy to Lower Cardiovascular Events (EVOLVE) study in dialysis patients is now anticipated in 2012.

Motesanib: The Company announced that data from the Phase 3 MONET-1 study in non-squamous non-small cell lung cancer is expected in the first half of 2011.

Non-GAAP Financial MeasuresManagement has presented its operating results in accordance with GAAP and on an “adjusted” (or non-GAAP) basis for the three and twelve months ended Dec. 31, 2010 and 2009. In addition, management has presented its outstanding debt in accordance with GAAP and on an “adjusted” (or non-GAAP) basis as of Dec. 31, 2010.  The Company believes that the presentation of non-GAAP financial measures provides useful supplementary information to and facilitates additional analysis by investors.  The Company uses these non-GAAP financial measures in connection with its own budge
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