Navigation Links
Amgen to Appeal CHMP Opinion on Vectibix® (Panitumumab) Use With Chemotherapy in Metastatic Colorectal Cancer in Europe
Date:3/30/2011

patients with wild-type KRAS mCRC, when standard chemotherapy is no longer effective. In the U.S., Vectibix received accelerated approval in September 2006 as a monotherapy for the treatment of patients with EGFR-expressing mCRC after disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. Furthermore, use of Vectibix is not recommended in patients whose tumors have KRAS mutations in codon 12 or 13. In Japan and Israel, Vectibix is also approved for use in combination with chemotherapy for patients with wild-type KRAS mCRC.

About KRAS

Results from studies performed over the last 25 years indicate that KRAS plays an important role in cell growth regulation. In mCRC, EGFR transmits signals through a set of intracellular proteins. Upon reaching the nucleus, these signals instruct the cancer cell to reproduce and metastasize, leading to cancer progression.(v) Anti-EGFR antibody therapies work by inhibiting the activation of EGFR, thereby inhibiting downstream events that lead to malignant signaling. However, in patients whose tumors harbor a mutated KRAS gene, the KRAS protein is always turned "on," regardless of whether the EGFR has been activated or therapeutically inhibited. KRAS mutations occur in approximately 40-50 percent of mCRC patients.(vi)(vii)

About Colorectal Cancer

Colorectal cancer is the third most common cancer worldwide in men and the second most common in women. In 2008, approximately 1.23 million cases of colorectal cancer were diagnosed globally.(viii) In 2008, there were an estimated 333,330 new cases of colorectal cancer in the EU.(ix)

About Vectibix

Vectibix is the first fully human anti-EGFR antibody approved by the U.S. Food and Drug Administration (FDA) for the treatment of mCRC. Vectibix was approved in the U.S. in September 2006 as a monotherapy for the t
'/>"/>

SOURCE Amgen
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6 7 8 9

Related medicine technology :

1. Amgen Donates $1 Million to Help Japanese Disaster Victims
2. Amgen Completes Acquisition of BioVex
3. NBPTS and Amgen Foundation Join to Bolster Science Education
4. Amgen to Present at the Citi 2011 Global Healthcare Conference
5. CURE Magazine Teams Up With Amgen Oncology and Breakaway from Cancer® to Launch 2011 Extraordinary Healer Award for Oncology Nursing
6. Boehringer Ingelheim to Purchase Amgens Fremont (USA) Facility
7. Amgen’s Fourth Quarter 2010 Adjusted Earnings Per Share Increased 11 Percent to $1.17; Full Year 2010 Adjusted Earnings Per Share Increased 6 Percent to $5.21
8. Genelux Corporation Expands Board of Directors, Appointing Dennis Fenton, Former Amgen Executive
9. Boehringer Ingelheim to Purchase Amgens Fremont (California) Facility
10. MedImmune In-Licenses Clinical-Stage Anti-Inflammatory Monoclonal Antibody From Amgen
11. Amgen to Present at the 29th Annual JP Morgan Healthcare Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... , May 23, 2013  Hadasit Bio-Holdings Ltd. (TASE: ... biotech companies, based on intellectual property developed and ... ,s foremost medical research center, today announced ... received significant funding from the Israeli Ministry of ... (OCS) to support product development and advance clinical ...
(Date:5/23/2013)... Mich. , May 23, 2013  Every day, their ... of air to his lungs. April and Bryan ... dire predictions weren,t true. "Quite a few doctors ... hospital alive," says April Gionfriddo , about ... desperate. Anything that would work, we would take it and ...
(Date:5/23/2013)... , May 23, 2013   Direct to ... mastectomy is an appropriate option for many women ... surgically reduce their breast cancer risk, or with ... expansion process and a second surgery to insert ... the same surgery as mastectomy can be a ...
Breaking Medicine Technology:Hadasit Bio-Holdings Ltd. Portfolio Company - Cell Cure Neurosciences Ltd. Received Additional Government Support 2Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 2Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 3Baby's life saved with groundbreaking 3D printed device from U-M that restored his breathing 4Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 2Direct to Implant ("One Step") Mastectomy Breast Reconstruction Reduces Number of Surgeries and Time to Final Cosmetic Results 3
... Varian Medical Systems, Inc. (NYSE: VAR ), ... cancer with radiotherapy, announced today it has received Shonin ... Welfare (MHLW) to market the TrueBeam™ system for image-guided ... of lung, breast, prostate, head and neck, and other ...
... June 15, 2011 Reportlinker.com announces that a ... catalogue: US Cardiac Assist Devices ... http://www.reportlinker.com/p0555154/US-Cardiac-Assist-Devices-–-Market-Trend-Till-2016.html?utm_source=prnewswire&utm_medium=pr&utm_campaign=Cardiovascular_Devices Short ... vital market data on the cardiac assist devices ...
Cached Medicine Technology:TrueBeam™ System for Non-Invasive Image-Guided Cancer Treatment Receives Shonin Approval 2TrueBeam™ System for Non-Invasive Image-Guided Cancer Treatment Receives Shonin Approval 3Reportlinker Adds US Cardiac Assist Devices -- Market Trend Till 2016 2Reportlinker Adds US Cardiac Assist Devices -- Market Trend Till 2016 3
(Date:5/24/2013)... 24, 2013 KC and Monica Craichy, Founders ... for FreeRide836. Their oldest sons, Kyle and Austin Craichy, will ... family and several professional kiteboarders. , KC Craichy said he ... has miraculously come together such that virtually everyone who planned ... , 20 kite boarders will meet at Matheson Hammock Park ...
(Date:5/24/2013)... 2013 CHI-California Healthcare Institute today ... California congressional delegation, joined by over 40 biomedical ... fees paid to the U.S. Food and Drug ... across-the-board cuts will not include user fees paid ... Rural Development and FDA Appropriations Bill. CHI is ...
(Date:5/24/2013)... Alzheimer,s researchers failed to replicate what appeared to be ... when they were published last year in the journal ... 9, 2012, suggested that the drug bexarotene (marketed as ... plaques (Aβ) a pathological hallmark of Alzheimer,s disease ... authors of the 2012 report, drug treatment quickly removed ...
(Date:5/24/2013)... to the development of infantile myofibromatosis (IM)a disorder characterized ... tissuemay provide new therapeutic targets, according to researchers from ... findings, published in the American Journal of Human ... this debilitating disease, for which the only current treatment ... IM is an inheritied disorder that develops in infancy ...
(Date:5/24/2013)... (HealthDay News) -- Low-income, minority parents have more ... are more open to vaccinating their daughters against ... new study contends. Conversely, white, middle-class parents ... their daughters, according to researchers from the Boston ... will get an HPV-related cancer each year, many ...
Breaking Medicine News(10 mins):Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 2Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 3Health News:California Biomedical Industry Leaders Urge Congress to Take Action on FDA User Fees for FY2014 2Health News:California Biomedical Industry Leaders Urge Congress to Take Action on FDA User Fees for FY2014 3Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 2Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 3Health News:Researchers identify first drug targets in childhood genetic tumor disorder 2Health News:Low-Income, Minority Parents More Open to HPV Vaccine for Girls, Study Says 2
... ... ... ... ...
... was cited at the conclusion of voting last week as ... Medical Blog Awards. The announcement of the winners noted ... societal and public policy issues, [Robert B. Doherty] runs one ... The sixth annual Medical Blog Awards were conducted by Medgadget ...
... imaging (MRI) is a good diagnostic tool for the ... patient care by sparing some men unnecessary surgery, according ... American Journal of Roentgenology ( www.ajronline.org ). ... the investigation of testicular masses," said Athina C. Tsili, ...
... ... Agreement with Boehringer Ingelheim (Canada) Ltd. , ... Toronto, Ontario, Canada (PRWEB) February 22, 2010 -- Dalton Pharma ... Under the agreement Dalton will continue to provide chemistry services in support of ...
... ... in command center training to prepare for disaster events. , ... (PRWEB) February 22, 2010 -- The DQE Training Division is ... The Hospital Command Center (HCC) onsite training course is an advanced level Hospital Incident ...
... , ... ... , , , , ... ...
Cached Medicine News:Health News:Rate Regulation for Health Insurance: Obama Administration Should Look to CA's Model Law Which Has Saved Drivers $62 Billion Since 1988 2Health News:Rate Regulation for Health Insurance: Obama Administration Should Look to CA's Model Law Which Has Saved Drivers $62 Billion Since 1988 3Health News:Rate Regulation for Health Insurance: Obama Administration Should Look to CA's Model Law Which Has Saved Drivers $62 Billion Since 1988 4Health News:Rate Regulation for Health Insurance: Obama Administration Should Look to CA's Model Law Which Has Saved Drivers $62 Billion Since 1988 5Health News:Rate Regulation for Health Insurance: Obama Administration Should Look to CA's Model Law Which Has Saved Drivers $62 Billion Since 1988 6Health News:ACP Advocate blog cited as best health policy/ethics Weblog 2Health News:Dalton Pharma Services and Boehringer Ingelheim (Canada) Ltd. Announce the Renewal of their Chemistry Services Agreement 2Health News:DQE Offers New Hospital Command Center Training 2Health News:Statewide Poll: Pennsylvania Must Adequately Fund Senior Care Services 2Health News:Statewide Poll: Pennsylvania Must Adequately Fund Senior Care Services 3
Williams Micro Discectomy Instruments are designed to be used in the microsurgical treatment of herniated disks....
Seletz-Gelpi Laminectomy Retractor, self-retaining with arms bent at right angles....
Valin Hemilaminectomy Retractor, self retaining with rack and pinion action....
Scoville Hemilaminectomy Retractor...
Medicine Products: