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Amgen and UCB Team Up With NASA on Final Space Shuttle Mission to Conduct Preclinical Test of Sclerostin Antibody on Bone Loss
Date:7/5/2011

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"We are very excited to be working on this momentous experiment. It will help us to better understand the sclerostin antibody," said Prof. Iris Loew-Friedrich, chief medical officer and executive vice president of Global Projects and Development at UCB. "The origin of UCB's sclerostin program was the discovery of the genetic cause of a rare inherited high bone mass condition. This fascinating approach of turning genetic discovery into novel and innovative drug development seems fitting to the collaboration with NASA whose mission is exploration and discovery."

AMG 785/CDP7851, a different sclerostin antibody than the one being used for this STS-135 mouse study, is currently in Phase 2 clinical trials for bone-related conditions, including postmenopausal osteoporosis and fracture healing, as a collaboration between Amgen Inc. and UCB.

About Amgen

Amgen discovers, develops, manufactures, and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science's promise by bringing safe, effective medicines from lab to manufacturing plant to patient. Amgen therapeutics have changed the practice of medicine, helping millions of people around the world in the fight against cancer, kidney disease, rheumatoid arthritis, bone disease, and other serious illnesses. With a deep and broad pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people's lives. To learn more about our pioneering science and vital medicines, visit www.amgen.com.

About UCB

UCB, Brussels, Belgium (www.ucb.com) is a global biopharmaceutical company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases of the immune system or of the central nervous system. With more than 8,000
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