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Amgen Presents New XGEVA™ (Denosumab) Breast Cancer Skeletal-Related Event Prevention Data at SABCS
Date:12/10/2010

us injection every four weeks, XGEVA provides a new option for urologists and oncologists to prevent serious bone complications in men with prostate cancer.

Amgen has submitted marketing applications for XGEVA in the prevention of SREs in the European Union, Australia, Canada and Switzerland. In Japan, Amgen is working with its licensing partner, Daiichi-Sankyo Company, Limited and a marketing application was submitted in August.

Bone Metastases and SREs: Economic Burden, Prevalence and Impact The total economic burden of patients with bone metastases in the U.S. alone is estimated to be $12.6 billion annually.(iii) Patients who experience an SRE as a result of bone metastases incur significantly higher medical costs compared with those who do not experience such events. (iv)(v)(vi) In addition, once patients experience an SRE, the risk of a subsequent SRE is increased. The costs of SREs vary by type and severity, ranging from relatively low costs for minor fractures to high cost events like spinal cord compression associated with hospitalization. Studies have shown that the costs of treating SREs are a significant cost burden.

Bone metastases occur in more than 1.5 million patients with cancer worldwide and are most commonly associated with cancers of the prostate, lung, and breast, with incidence rates as high as 75 percent of patients with metastatic disease.(vii)

Approximately 50-70 percent of cancer patients with bone metastases will experience debilitating SREs. (viii)(ix)(x) Events considered to be SREs include fractures, spinal cord compression, and severe bone pain that may require surgery or radiation.(xi) Such events can profoundly disrupt a patient's life and can cause disability and pain. (xii)(xiii)(xiv)

Denosumab and Amgen's Research in Bone BiologyThe denosumab development program demonstrates Amgen's commitment to researching and delivering pioneering medicines to patients with unmet medical
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