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Amgen Presents New XGEVA™ (Denosumab) Breast Cancer Skeletal-Related Event Prevention Data at SABCS
Date:12/10/2010

p://www.amgen.com/">www.amgen.com for full prescribing information.

Denosumab is also marketed as Prolia™ in other indications.

D-CARE: XGEVA Adjuvant Breast Cancer Study Enrolling Patients NowAs part of Amgen's continued commitment to improving outcomes for people living with breast cancer, XGEVA is also being investigated as adjuvant treatment for women with early-stage breast cancer who are at high-risk of disease recurrence. A large Phase 3 study known as D-CARE is comparing the treatment effect of denosumab with that of placebo on prolonging bone metastasis-free survival (BMFS), and on prolonging disease-free survival (DFS). The trial will enroll 4,500 patients. For more information, please visit www.clinicaltrials.gov (identifier number 01077154).

XGEVA FIRST STEP™ COUPON PROGRAMAmgen is committed to supporting patient access to important medicines through innovative programs including our newly established commercial co-pay program for XGEVA, the Safety Net Foundation, which provides free Amgen products to uninsured patients who qualify, and financial support to independent third party co-pay foundations. The XGEVA FIRST STEP™ Coupon Program is a landmark program among oncology commercial co-pay programs, as it is the first program under the medical benefit with no income eligibility requirement.  The program offers a coupon to eligible patients that can be used to help meet their deductible, co-insurance, and/or co-payment requirements under the medical benefit for XGEVA. For more information, please visit http://www.amgenfirststep.com/.

XGEVA Regulatory StatusXGEVA was approved by the FDA for the prevention of SREs in patients with bone metastases from solid tumors on Nov. 18, 2010. XGEVA is not indicated to prevent SREs in patients with multiple myeloma. Administered as a single 120 mg subcutaneo
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