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Amgen Presents New XGEVA™ (Denosumab) Breast Cancer Skeletal-Related Event Prevention Data at SABCS
Date:12/10/2010

EVA patients (3.5 percent fewer [range: -1.1 percent to 11.5 percent fewer]) than Zometa treated patients had a meaningful decrease in health-related quality of life over the 18 months.  

Interim Results Demonstrate Skeletal-Related Events in Breast Cancer Patients are Associated with Considerable Health Resource Utilization (Abstract Number: P1-13-06)SREs have an adverse financial impact on healthcare systems, consuming significant resources. The first interim results from the breast cancer section (n=67) of an ongoing study assessing the health resource utilization per type of SRE (119 discreet SREs) found that pathologic fracture required the longest hospital stay (19 days, n=18), with spinal cord compression requiring the second most days (13.3 days, n=5). Additionally, radiation to bone required the most procedures (14.7, n=87), such as imaging, followed by spinal cord compression (10.4, n=5).

This section of an ongoing observational, multinational study assessed SRE-related utilization of health resources by SRE type (surgery or radiation to bone, pathologic fracture, or spinal cord compression) in breast patients with bone metastases. Data was collected on inpatient hospitalizations, length of stay, outpatient visits, emergency room (ER) visits, nursing home/long-term care facility stays, home health visits, procedures, and medications.

Acute Phase Reactions Following Treatment with Zometa or XGEVA (Abstract Number: P6-14-09) An analysis of the Phase 3 "136" data compared the potential for acute phase reactions following treatment with either Zometa or XGEVA. Results of this analysis will be presented Sunday, Dec. 12 at 7:00 a.m. CT.

About the XGEVA Phase 3 Breast Cancer SRE Prevention Study "136" Study "136" is an international, Phase 3, randomized, double-blind study comparing XGEVA with Zometa in the treatment of bone metastases in patients with advanced breast cancer to prevent SREs. Patients enrolled in the st
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