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Amgen Presents New XGEVA™ (Denosumab) Breast Cancer Skeletal-Related Event Prevention Data at SABCS
Date:12/10/2010

86 days Zometa; p=0.09) and time to pain worsening tended to be longer with XGEVA compared to Zometa (n=1676; median: 394 days XGEVA vs. 310 days Zometa; p=0.13).

In patients with no or mild pain at the beginning of the study, XGEVA also demonstrated a trend for shorter time to improvement for pain interference with daily functioning (n=388; 93 days XGEVA vs. 120 days Zometa; p=0.06) and levels of pain took a longer time to worsen, interfering with daily functioning (n=755; 369 days XGEVA vs. 232 days Zometa; p=0.12).

Breast Cancer Patients' Health-Related Quality of Life Improved When Receiving XGEVA Compared to those Receiving Zometa (Abstract Number: P1-13-05)A third analysis presented yesterday found that a greater proportion of breast cancer patients treated with XGEVA had a meaningful improvement in health-related quality of life compared to those treated with Zometa, regardless of their pain level at baseline.

Specifically, among patients who reported no or mild pain at the beginning of the study, more patients receiving XGEVA had a meaningful (greater than 5 point increase) in their functional assessment score (as measured by FACT-G) compared to patients receiving Zometa. Over the 18 month period, an average of 4.1 percent more (range: -0.6 percent to 9.3 percent) XGEVA-treated patients experienced meaningful improvement in health-related quality of life than Zometa patients. Additionally, fewer patients on XGEVA experienced a meaningful decrease in health-related quality of life over the same timeframe (average of 2.4 percent fewer [range:-4.4 percent to 6.3 percent fewer]).

Similar patterns were found in patients with moderate to severe pain at the beginning of the study.  An average of three percent more (range:-1.7 percent to 7.9 percent) XGEVA-treated patients experienced a meaningful increase in their health-related quality of life compared with Zometa patients over 18 months.  Also, a lower proportion of XG
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