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Amgen Oncology Data to be Presented at ASCO Annual Meeting
Date:5/18/2011

d hospitals must enroll in and comply with the ESA APPRISE Oncology Program to prescribe and/or dispense Aranesp, EPOGEN® or PROCRIT® to patients with cancer. To enroll in the ESA APPRISE Oncology Program, visit http://www.esa-apprise.com/ or call 1-866-284-8089 for further assistance.
  • Use ESAs only for treatment of anemia due to concomitant myelosuppressive chemotherapy.
  • ESAs are not indicated for patients receiving myelosuppressive therapy when the anticipated outcome is cure.
  • Discontinue following the completion of a chemotherapy course.
  • ESAs are contraindicated in patients with uncontrolled hypertension.

  • Important European Aranesp Product Safety InformationFor full prescribing information please see the Summary of Product Characteristics.

    Aranesp is indicated for treatment of symptomatic anaemia in adult cancer patients with non-myeloid malignancies receiving chemotherapy.

    Aranesp is contraindicated in patients with poorly controlled hypertension.

    Controlled clinical trials have not shown significant benefits attributable to the administration of epoetins when haemoglobin concentration is increased beyond the level necessary to control symptoms of anaemia and to avoid blood transfusion.

    In controlled clinical studies, use of Aranesp and other ESAs have shown:

  • shortened time to tumour progression in patients with advanced head and neck cancer receiving radiation therapy when administered to target Hb > 14 g/dL; ESAs are not indicated for use in this patient population
  • shortened overall survival and increased deaths attributed to disease progression at 4 months in patients with metastatic breast cancer receiving chemotherapy when administered to target Hb 12-14 g/dL
  • increased risk of death when administered to target Hb of 12 g/dl (7.5 mmol/l) in patien
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  • SOURCE Amgen
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