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Amgen Oncology Data to be Presented at ASCO Annual Meeting
Date:5/18/2011

(mPC)

(Abstract 4049) Poster on Saturday, June 4, 8:00 a.m. - 12:00 p.m., Hall A


  • A randomized, placebo-controlled phase II study of AMG 386 plus bevacizumab (Bev) and paclitaxel (P) or AMG 386 plus P as first-line therapy in patients (pts) with HER2-negative, locally recurrent or metastatic breast cancer (LR/MBC)

  • (Abstract 544) Poster on Monday, June 6, 1:00 p.m. - 5:00 p.m., Hall A


  • An international, randomized, placebo-controlled, double-blind phase III study (MONET1) of motesanib plus carboplatin/paclitaxel (C/P) in patients with advanced nonsquamous non-small cell lung cancer (NSCLC)

  • (Abstract LBA7512) Poster Discussion on Monday, June 6, 2:00 p.m. - 6:00 p.m., E450aFor the latest updates on Amgen's presence at ASCO and other Amgen news, follow us on Twitter @Amgen.About XGEVAXGEVA is the first and only RANK Ligand inhibitor approved by the U.S. Food and Drug Administration (FDA) that is indicated for the prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors. XGEVA is not indicated for the prevention of SREs in patients with multiple myeloma. XGEVA is the first novel bone metastases treatment for patients with advanced cancer in nearly a decade. Delivered as an every four week 120 mg subcutaneous injection, XGEVA provides a unique option for urologists and oncologists to prevent SREs in patients with advanced cancer.

    XGEVA is a fully human monoclonal antibody that binds to RANK Ligand, a protein essential for the formation, function and survival of osteoclasts (the cells that break down bone). XGEVA prevents RANK Ligand from activating its receptor, RANK, on the surface of osteoclasts, thereby decreasing bone destruction.

    The clinical program for XGEVA spanned more than 50 tumor types in more than 5,700 patients. In clinical trials, XGEVA demonstrated a clinically meaningful improvement
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