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Amgen Highlights Key Clinical Data to be Presented at European Society for Medical Oncology Congress
Date:10/5/2010

dy of AMG 386 plus weekly paclitaxel in patients (pts) with advanced ovarian cancer (Abstract Number 975PD; Poster Discussion; Saturday, Oct. 9, 1:00 p.m. CET, Yellow Hall 1)


  • Exposure-response relationships of AMG 386 in combination with weekly paclitaxel in advanced ovarian cancer: facilitation of Phase 3 dose selection by population pharmacokinetic/pharmacodynamic (PK/PD) modeling (Abstract Number 983P; Poster; Sunday, Oct. 10, 12:30-1:30 p.m. CET, Hall 3)


  • Open-label phase 1b study of AMG 386, a selective angiopoietin1/2-neutralizing peptibody, in combination with sorafenib or sunitinib in advanced renal cell carcinoma (RCC): interim results(Abstract Number 505P; Poster; Monday, Oct. 11, 12:30-1:30 p.m. CET, Hall 3)


  • Conatumumab (CON) or AMG 479 or placebo (pbo) + gemcitabine (gem) in patients (pts) with metastatic pancreatic cancer (mPC): a placebo-controlled, randomized, Phase 2 study (Abstract Number 741P; Poster; Saturday, Oct. 9, 1:00-2:00 p.m. CET, Hall 3)


  • Safety and pharmacokinetics of first-line AMG 479 (MAb to IGF1R) or AMG 102 (MAb to HGF/SF) with platinum-based chemotherapy in extensive-stage small cell lung cancer (SCLC) (Abstract Number 444P; Poster; Monday, Oct. 11, 12:30-1:30 p.m. CET, Hall 3)Vectibix® (panitumumab)

  • Primary efficacy and safety results of SPECTRUM, a Phase 3 trial in patients (pts) with recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN) receiving chemotherapy with or without panitumumab (pmab)(Abstract Number LBA26; Oral Presentation; Monday, Oct. 11, 1:30-2:45 p.m. CET, Blue Hall)


  • Single-centre experience of quality assurance (QA) measures in a Phase 2 trial of radiotherapy (RT) + panitumumab vs chemo-RT (CRT) in patients with locally advanced squamous cell carcinoma of the head
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