Navigation Links
Amgen Announces Top-Line Results Of Phase 3 Trebananib (AMG 386) TRINOVA-1 Trial In Recurrent Ovarian Cancer
Date:6/12/2013

erience disease recurrence and eventually die from their disease.2,3

TRINOVA-1 Trial Design (NCT01204749)
TRINOVA-1 is a Phase 3 global, multicenter, randomized, double-blind, placebo-controlled study evaluating trebananib in over 900 women with recurrent partially platinum-sensitive or -resistant (platinum-free interval of 12 months or less) epithelial ovarian, primary peritoneal or fallopian tube cancer. Patients were randomized 1:1 to receive either 15 mg/kg of intravenous trebananib weekly plus 80 mg/m2 of intravenous paclitaxel weekly (three weeks on, one week off) or weekly intravenous placebo plus 80 mg/m2 of intravenous paclitaxel weekly (three weeks on, one week off).

Other ongoing Phase 3 studies of trebananib include TRINOVA-2 and TRINOVA-3. TRINOVA-2 is evaluating whether trebananib plus pegylated liposomal doxorubicin (PLD) is superior to placebo plus PLD as measured by PFS in recurrent epithelial ovarian, primary peritoneal or fallopian tube cancer. TRINOVA-3 is evaluating trebananib or placebo in combination with paclitaxel and carboplatin in the first-line treatment of epithelial ovarian, primary peritoneal or fallopian tube cancer.

About Trebananib
Trebananib is an investigational peptibody designed to inhibit the angiopoietin axis. The angiopoietin axis is involved in angiogenesis, a process used by the body to grow new blood vessels, which is also involved in the pathogenesis of several diseases. Trebananib is designed to bind to both angiopoietin-1 and -2 (Ang1 and Ang2), and inhibit their interaction with the Tie2 receptor.4,5,6 Ang1 and Ang2 each mediate separate actions upon binding with Tie2.7,8 Ang1 impacts vessel quality while Ang2 influences vessel quantity. The angiopoietins are also involved in lymphangiogenesis, the formation of new lymphatic vessels, which plays a key role in tumor metastasis.9

About Amgen
Amgen discovers,
'/>"/>

SOURCE Amgen
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Amgen Presents Positive Results From Talimogene Laherparepvec Phase 3 Study In Patients With Metastatic Melanoma
2. Amgen To Webcast Investor Meeting At Upcoming American Society Of Clinical Oncology Annual Meeting
3. Amgen And Astellas Announce Japan Alliance
4. Amgen to Present at the Deutsche Bank 38th Annual Healthcare Conference
5. Amgen To Present At The UBS Global Life Sciences Conference
6. The Zacks Analyst Blog Highlights: Genomic Health, Sanofi, Regeneron Pharmaceuticals, Amgen and Isis Pharmaceuticals
7. Amgen Highlights Data To Be Presented At American Society of Clinical Oncology Annual Meeting
8. Amgen, Hospira and Sandoz Named Among Top Pharmaceutical Companies with Greatest Biosimilar Drug Potential in United States
9. Amgen And Zhejiang Beta Pharma Announce Planned Joint Venture In China
10. Amgens First Quarter 2013 Revenues Increased 5 Percent To $4.2 Billion And Adjusted Earnings Per Share (EPS) Increased 22 Percent To $1.96
11. Amgen Announces Webcast of 2013 First Quarter Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 2014  Aratana Therapeutics, Inc. (NASDAQ: ... licensing, developing and commercializing innovative biopharmaceutical products for ... public offering of 4,500,000 shares of its common stock at ... share. Aratana has granted the underwriters a 30-day ... shares of its common stock. Jefferies ...
(Date:9/17/2014)... Calif. , Sept. 17, 2014 ... announced that it has earned a $4 million ... AKAO ) associated with the initiation of a ... serious multi-drug resistant (MDR), gram-negative bacterial infections.  The ... study to evaluate the efficacy and safety of ...
(Date:9/17/2014)... MILL VALLEY, Calif. , Sept. 17, ... announced a partnership in the fight against sarcoma. ... Sarcoma Alliance Suzanne Renee Leider Memorial Assistance Fund. ... assistance to reimburse sarcoma patients for expenses directly ... sarcoma specialist. Scientific literature reinforces the importance of ...
Breaking Medicine Technology:Aratana Therapeutics, Inc. Announces Pricing of Public Offering 2Isis Pharmaceuticals Earns $4 Million from Achaogen for the Initiation of a Phase 3 Study of Plazomicin 2Isis Pharmaceuticals Earns $4 Million from Achaogen for the Initiation of a Phase 3 Study of Plazomicin 3Champions Oncology Partners with Sarcoma Alliance to Bring Personalized Treatment Options to Sarcoma Patients 2Champions Oncology Partners with Sarcoma Alliance to Bring Personalized Treatment Options to Sarcoma Patients 3
(Date:9/17/2014)... Ohio (PRWEB) September 18, 2014 ... management services nationwide, announces today that they have ... Wayne Radiology (FWRadiology) in Fort Wayne, Indiana. ... of billing services encompassing their proprietary suite of ... (EBT). EBT improves radiology billing and data ...
(Date:9/17/2014)... 17, 2014 As kinship care continues ... who cannot live with their parents, emphasis on kinship ... to enhance services and supports for kinship caregivers and ... National Kinship Care Conference is being held this week ... best practice, policy, program and service development for kinship ...
(Date:9/17/2014)... Historically, spaceflight has been reserved for the very ... meet the highest physical and psychological standards to ... the advent of commercial spaceflight, average people can ... has had very little information about what medical ... in the spaceflight environment, as most medical conditions ...
(Date:9/17/2014)... September 17, 2014 People who struggle to ... head to http://www.perwickstrom.com and get the answer by ... to point out, is that a business plan and a ... work together, commented Per Wickstrom. “The way I view it ... a business strategy which is part two.” , According ...
(Date:9/17/2014)... these sound like the ideas of a ... components of an exciting new approach to imaging ... of metastatic prostate cancer, scientists at Virginia Commonwealth ... Medicine and Johns Hopkins Medical Institutions have provided ... could revolutionize doctors, ability to see tumors that ...
Breaking Medicine News(10 mins):Health News:ADVOCATE Wins Radiology Billing Agreements with Fort Wayne Radiology 2Health News:ADVOCATE Wins Radiology Billing Agreements with Fort Wayne Radiology 3Health News:Arizona’s Children Association Kinship Service Providers Invited to Present at the CWLA National Conference 2Health News:Space: The final frontier… open to the public 2Health News:Per Wickstrom’s Latest Blog Explores the Difference Between a Business Plan and a Business Strategy 2Health News:New non-invasive technique could revolutionize the imaging of metastatic cancer 2Health News:New non-invasive technique could revolutionize the imaging of metastatic cancer 3
... Global pharma major Wyeth Tuesday launched its blockbuster ... pneumococcal disease among infants and toddlers//. ,Pneumococcal ... streptococcus pneumoniae, also known as the "pneumococcus" bacteria. ... that is expected to prevent pneumococcal diseases like ...
... of 87 Hepatitis cases have been detected in Moga out ... health department said today//. ,The infected people ... of 13 doctors, Civil Surgeon Dr H P S Sandhu ... 69 cases from a private doctor and the local clinical ...
... claimed 24 lives in Meghalaya's Garo Hills region bordering Assam ... told the assembly today//. ,Replying to a ... death toll in Garo Hills had gone up this year ... high number of deaths and most of the places affected ...
... research has further confirmed the theory that environmental factors ... diabetes //in children and young adults. ,The ... and Leeds Teaching Hospitals NHS Trust, carried out a ... the times and places where the children and young ...
... found for the first time that human embryonic stem ... into mature T-cells//, raising hopes for a gene therapy ... Institute and the Institute for Stem Cell Biology and ... human embryonic stem cells into blood-forming stem cells that ...
... to a recent survey it was found that international nurses would ... in the NHS//. ,The step was mainly taken to ... 11,500 foreign nurses come to Britain from outside the European Union ... followed by the Philippines and Australia. The rule applies to nurses ...
Cached Medicine News:Health News:Environmental Factors Trigger Onset of Diabetes 2Health News:T-cells Developed from Human Embryonic Stem Cells 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: