Navigation Links
Amgen Announces Overall Survival Results for Vectibix(R) in First-Line Metastatic Colorectal Cancer
Date:11/5/2009

ombination with oxaliplatin-based chemotherapy, including known events such as rash, diarrhea and hypomagnesemia. Vectibix-related grade 3 infusion reactions were reported for two patients (less than 1 percent).

Originally designed to compare the treatment effect in the overall population, the study was amended to analyze outcomes with respect to the presence or absence of activating mutations in KRAS in the tumor itself. Tumor KRAS status was ascertained in more than 90 percent of the 1,183 patients enrolled in the trial.

Available results from the trial were presented earlier this year at the 2009 ECCO 15 - ESMO 34 European Multidisciplinary Congress in Berlin, Germany showing that Vectibix significantly improved median progression-free survival by 1.6 months (9.6 versus 8.0 months for patients treated with FOLFOX alone, in patients with KRAS wild-type mCRC (primary endpoint). Further, the addition of Vectibix to chemotherapy also improved response rate in the KRAS wild-type patient population as measured by blinded central review (55 percent versus 48 percent in the FOLFOX only arm).

The data for the 203 study has been submitted for consideration of presentation at the American Society of Clinical Oncology - The Gastrointestinal Cancers Symposium Meeting for 2010.

Study Design

Patients enrolled in the "203" or PRIME trial (Panitumumab Randomized trial in combination with chemotherapy for Metastatic colorectal cancer to determine Efficacy) were randomized to receive either 6.0 mg/kg of Vectibix and FOLFOX4 once every two weeks (Q2W) or FOLFOX4 alone Q2W. The primary endpoint of the study is progression-free survival by KRAS status and secondary endpoints include overall survival, objective response rate, time to progression, duration of response and safety.

About KRAS

Results from studies performed over the last twenty-five y
'/>"/>

SOURCE Amgen
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Call for Applications: The Amgen Award for Science Teaching Excellence
2. Amgen Highlights Data to be Presented at American Society for Bone and Mineral Research (ASBMR) Meeting
3. Amgen Announces Top-Line Results of Trial to Reduce Cardiovascular Events With Aranesp(R) Therapy (TREAT) in CKD Patients With Type-2 Diabetes
4. Amgen Issues Statement on Outcomes of Advisory Committee for Reproductive Health Drugs (ACRHD) Meeting
5. Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)
6. CDC Foundation Partners with Amgen, CDC to Reduce Infections Among Cancer Patients
7. Amgen, Takeda and Millennium Provide Update on Phase 3 Trial of Motesanib in Patients With Non-Small Cell Lung Cancer
8. AMT Obtains License to Amgens GDNF Gene to Develop Treatment for Parkinsons Disease with AMTs Proprietary Gene Therapy Platform
9. Medarex to Receive Milestone Payment from Amgen
10. Arthritis Foundation Announces Amgen and Wyeth to Be Presenting Sponsor of the 2008 Arthritis Walk (R)
11. Reminder Webcast Alert: Transgenomic, Inc. Announces Third Quarter 2009 Earnings Release Conference Call Webcast
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/4/2015)... Calif., Aug. 4, 2015  Xencor, Inc. (NASDAQ: ... engineered monoclonal antibodies for the treatment of autoimmune ... reported financial results for the second quarter ended June ... business highlights. "Currently eight XmAb® antibody ... and two internal. The accelerating momentum of this ...
(Date:8/4/2015)... FRAMINGHAM, Mass. , Aug. 4, 2015 ... a leading innovator of less invasive, miniaturized circulatory support ... failure, today announced that its President and Chief Executive ... at the Canaccord Genuity 35th Annual Growth Conference at ... conference is being held August 12-13, 2015 at the ...
(Date:8/4/2015)... Aug. 04, 2015 ... the addition of the "MRI Systems Market ... Operational Efficiency, with Growth Driven by Developing Economies" ... Systems Market to 2020 - Focus on Patient ... Developing Economies" discusses the market, competitive landscape, and ...
Breaking Medicine Technology:Xencor Reports Second Quarter 2015 Financial and Operating Results 2Xencor Reports Second Quarter 2015 Financial and Operating Results 3Xencor Reports Second Quarter 2015 Financial and Operating Results 4Xencor Reports Second Quarter 2015 Financial and Operating Results 5Xencor Reports Second Quarter 2015 Financial and Operating Results 6Xencor Reports Second Quarter 2015 Financial and Operating Results 7Xencor Reports Second Quarter 2015 Financial and Operating Results 8Xencor Reports Second Quarter 2015 Financial and Operating Results 9HeartWare Presentation At The Canaccord Genuity 35th Annual Growth Conference To Be Webcast 2Global MRI Systems Market Outlook to 2020 - Focus on Patient Comfort and Operational Efficiency, with Growth Driven by Developing Economies 2
... WASHINGTON, Dec. 15 Today,s New York Times ... Spurs Division," illustrates an internal renal community reimbursement debate that ... their life-saving immunosuppressive medications beyond the current 36-month Medicare program ... transplant patient coverage to preserve the lives of transplant kidney ...
... , , NEW YORK, Dec. 15 ... available in its catalogue: , Systemic Lupus Erythematosus ... , http://www.reportlinker.com/p0167308/Systemic-Lupus-Erythematosus---Drug-Pipeline-Analysis-and-Market-Forecasts-to-2015.html , Systemic Lupus ... 2015 , Summary , GlobalData, the industry ...
Cached Medicine Technology:AST Concerned That Kidney Transplant Patients May Suffer Politics As Usual in Capitol Hill Health Care Reform Debate 2Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 2Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 3Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 4Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 5Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 6Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 7Reportlinker Adds Systemic Lupus Erythematosus - Drug Pipeline Analysis and Market Forecasts to 2015 8
(Date:8/4/2015)... ... August 04, 2015 , ... ... the Assisted Dumbbell Bench Rack, a fitness invention that eliminates the need to ... Gym, Health and Fitness Clubs industry is worth $30 billion," says Scott Cooper, ...
(Date:8/4/2015)... ... 2015 , ... Exsurco Medical, Inc. is proud ... as an Affiliate Member. Exsurco Medical finds this an exciting opportunity to ... lives by promoting the safety, quality and availability of donated tissue for transplantation, ...
(Date:8/4/2015)... , ... August 04, 2015 , ... ... platform that uses Cloud innovation to consolidate oncology patient assistance programs. Through a ... single point of access. assistPoint is an enterprise level, cloud-based application and workflow ...
(Date:8/4/2015)... ... ... Atlantic Health System, one of the largest health care organizations in New Jersey, was ... list of the 20 Best Workplaces in Health Care. , Ranked at No. 4, ... and Atlantic Rehabilitation, is the highest-ranking company from New Jersey on the list. , ...
(Date:8/4/2015)... ... August 04, 2015 , ... The United Nations Foundation ... rights in Indonesia for a select group of U.S.-based journalists during the week ... and attend the International Conference on Family Planning in Bali. , In ...
Breaking Medicine News(10 mins):Health News:As The Navy Changes Body-Fat Rules, the World Patent Marketing Review Team Announces the Development of the Assisted Dumbbell Bench Rack 2Health News:As The Navy Changes Body-Fat Rules, the World Patent Marketing Review Team Announces the Development of the Assisted Dumbbell Bench Rack 3Health News:As The Navy Changes Body-Fat Rules, the World Patent Marketing Review Team Announces the Development of the Assisted Dumbbell Bench Rack 4Health News:As The Navy Changes Body-Fat Rules, the World Patent Marketing Review Team Announces the Development of the Assisted Dumbbell Bench Rack 5Health News:As The Navy Changes Body-Fat Rules, the World Patent Marketing Review Team Announces the Development of the Assisted Dumbbell Bench Rack 6Health News:Exsurco Medical Joins AATB as Affiliate Member 2Health News:assistPoint.com Web Site Launched 2Health News:Atlantic Health System Named a 'Best Workplace in Health Care' by Fortune, Great Place to Work® 2Health News:Atlantic Health System Named a 'Best Workplace in Health Care' by Fortune, Great Place to Work® 3Health News:Atlantic Health System Named a 'Best Workplace in Health Care' by Fortune, Great Place to Work® 4Health News:UN Foundation Announces Press Fellowship to Indonesia with Focus on Women’s Health and Rights 2
... ... , ... IN (PRWEB) July 7, 2009 -- Press Ganey Associates, Inc. today announced it will ... PatientFlow teams. The new office, slated to open in mid-August, will employ IT and ...
... announced today that it has hired Kathy Taylor-Laws as ... Taylor-Laws brings more than 25 years of experience in ... will be responsible for the development and management of ... SCAN,s members throughout Maricopa County. "Access to quality care ...
... WASHINGTON, July 7 The American Association of Homes ... Obama Administration for affirming their commitment to the millions ... supports. In a letter to the Senate Health, Education, ... and Human Services Secretary Kathleen Sebelius expressed the Obama,s ...
... Despite the increase of breast reconstruction procedures performed in ... for the procedure are not informed of the reconstructive ... report. Newly released statistics by the American Society of ... breast reconstruction procedures performed in 2008 a 39 ...
... five and a half pounds at birth often enter ... respiratory problems. New research shows that these respiratory problems ... into adulthood. "We report a previously unrecognized ... adults with a history of low birth weight," wrote ...
... HOUSTON, July 7 Skinovative(R), one of the country,s ... FDA approved non-invasive body contouring procedure, the Zerona(TM) Laser, ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20090707/DA42438LOGO ) , , ... fat and contour the body without invasive surgery. Recent ...
Cached Medicine News:Health News:Press Ganey Announces Opening of Boston Office 2Health News:SCAN Health Plan Selects Kathy Taylor-Laws as Vice President of Network Management Services 2Health News:Obama Administration Advances Long-Term Services and Supports in Health Care Reform 2Health News:Are breast cancer patients being kept in the dark? 2Health News:Low birth weight linked to long-term respiratory problems 2Health News:Low birth weight linked to long-term respiratory problems 3Health News:Skinovative(R) Announces a Safe Non-Surgical Liposuction Alternative With the Launch of Zerona(TM) Laser. 2Health News:Skinovative(R) Announces a Safe Non-Surgical Liposuction Alternative With the Launch of Zerona(TM) Laser. 3
... technology is the first and ... patented digital sensor all ... sensor. Dolphin ONE™ sensors both ... in the sensor, resulting in ...
Immersion Oil, 21,000 cs...
Immersion Oil, 1,250 cs...
... the standard - the ones to compare with, ... consistently led in the development and standardization of ... the record: , When the FDA set general ... Vitro Diagnostics in the 1970's, Cargille Immersion Oils ...
Medicine Products: