Date:2/26/2010

he findings come from a subset of patients who participated in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial, which tested the efficacy of the two drugs in people with irregular heart rhythm called atrial fibrillation.  Researchers enrolled RE-LY participants at 951 sites in 44 countries, including the United States.  They randomized patients to receive warfarin —adjusted to maintain the drug's therapeutic range — or to 110 mg or 150 mg of dabigatran taken twice daily for a median of two years.

In the subgroup of 3,623 patients with both a history of either stroke or transient ischemic attack (TIA), stroke or clot in other blood vessels occurred in 64 patients on warfarin (2.74 percent a year), 55 on low-dose dabigatran (2.32 percent a year) and 51 on high-dose dabigatran (2.07 percent a year).  

Neither of these differences was significant.

The rates of major bleeding events were significantly lower (32 percent less likely) in patients taking the lower dose of dabigatran compared to those taking warfarin, but it was not reduced in patients on the higher dose.

'/>"/>

SOURCE American Heart Association Copyright©2010 PR Newswire. All rights reserved

0 GOOD

Page: 1 2 3 4 5 6 7
Related medicine technology :

1. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
2. Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate
3. GlaxoSmithKline Receives New HHS Order for H5N1 Bulk Antigen. First North American Clinical Trials with GSKs Candidate Pre-pandemic Flu Vaccine to Start.
4. Aspirin Named 8th World Wonder by Majority of Americans
5. MedImmunes Motavizumab Reduced RSV Hospitalizations by 83 Percent Among High-Risk Native American, Full-Term Infants in Placebo-Controlled Phase 3 study
6. American Heart Association Comment Saving Lives in Type 2 Diabetics: Could It Be as Easy as Lowering Blood Pressure?
7. TrialCheck(R) Cancer Clinical Trial Matching Interface to Debut on American Cancer Society Web Site
8. Hypertension: Journal of the American Heart Association Rapid Access Reports: Hispanics Hypertension Better Controlled With Equal Access to Care
9. Positive Results for NKTR-118 (oral PEG-naloxol) Presented at American Academy of Pain Management Meeting
10. Preimplantation Genetic Diagnosis International Society Refutes American Society of Reproductive Medicine Opinion - States Preimplantation Genetic Screening is Beneficial When Performed in Experienced Centers
11. New MIRCERA(R) Data Analyses to be Featured at the American Society of Nephrology Annual Meeting