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American Stroke Association Late-Breaking Science Report: Antiplatelet Drug May Be Better Than Aspirin in Preventing Recurrent Strokes
Date:2/26/2010

"The primary implication of this trial is that the risk of recurrence of stroke in patients can be reduced without increasing the incidence of hemorrhage by oral administration of cilostazol," Shinohara said.  

Cilostazol is approved in the United States only for reducing intermittent claudication, pain caused by an inadequate flow of blood to the leg muscles that's common with peripheral vascular disease.  In Japan, the drug is recommended and widely used for preventing recurrence of ischemic stroke.

Shinohara and colleagues sought to determine whether cilostazol's preventive powers were in the same range as — or superior to — the effects of aspirin.

The researchers analyzed results from 2,681 ischemic stroke patients treated in 278 Japanese institutions between December 2003 and October 2006.  Patients were followed through 2008. All patients had suffered non-cardioembolic ischemic stroke within 26 weeks prior to enrollment and their symptoms had remained stable.  They were randomized to receive either 100 mg of cilostazol twice daily or 81 mg of aspirin once daily. '/>"/>

SOURCE American Stroke Association
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