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American Journal of Medicine Publishes Hypertension Study Comparing the Fixed-Dose Combination of Azilsartan Medoxomil and Chlorthalidone versus Azilsartan Medoxomil Co-administered with Hydrochlorothiazide
Date:9/5/2012

DEERFIELD, Ill., Sept. 5, 2012 /PRNewswire/ -- Results of a 10-week, phase 3 study published online in the American Journal of Medicine found the clinic systolic blood pressure (SBP) reductions of a fixed-dose combination of azilsartan medoxomil and chlorthalidone were significantly greater at six and ten weeks than those of azilsartan medoxomil co-administered with hydrochlorothiazide. Data also showed that more patients achieved their target blood pressure levels at the end of six and 10 weeks (secondary endpoints) when taking the azilsartan medoxomil and chlorthalidone fixed-dose combination.

"Hypertension management can be complex, and the use of combination therapy with a diuretic is a common treatment approach," said study co-author William C. Cushman, M.D., professor of preventive medicine at the University of Tennessee College of Medicine in Memphis, Tenn. "While hydrochlorothiazide is more commonly used in clinical practice, this study provides further support for the use of chlorthalidone in fixed-dose combination for patients with hypertension."

About the Study
The 10-week, randomized, double-blind, titrate-to-target study compared blood pressure reductions of the fixed-dose combination of azilsartan medoxomil and chlorthalidone to azilsartan medoxomil co-administered with hydrochlorothiazide among 609 patients with stage 2 hypertension. The average age of patients in the study was 56.4 years and the average baseline clinic blood pressure was 164.6/95.4 mm Hg. After two weeks of treatment with azilsartan medoxomil (40 mg) alone, patients received 12.5 mg of either diuretic for four weeks (up to week 6) and were then titrated to 25 mg for another four weeks (up to week 10) if they had not achieved their target blood pressure; otherwise, patients continued their initial dose.

Primary endpoint data showed that at week 6, the clinic SBP reductions of the fixed-dose combination of azilsartan medoxomil and chlorthalidone wer
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SOURCE Takeda Pharmaceuticals U.S.A., Inc.
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