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American Heart Association Late-Breaking Clinical Trial Report: New Reversible Oral Drug Reduces Cardiac Events in Primary PCI Patients
Date:11/15/2009

eceptor so that the drug does not bind permanently to the receptor, and the receptor and the platelet can regain function, with normal platelet clotting ability returning in about four days, which may explain the absence of increased bleeding with ticagrelor," Steg said. "However, ticagrelor does have off-target effects, which probably explain a side effect more commonly seen with ticagrelor than clopidogrel: dyspnea, or breathlessness, which affected 12.9 percent of ticagrelor patients and 8.3 percent of the clopidogrel group."

Overall mortality was reduced with ticagrelor -- from 6.0 percent to 4.9 percent, a relative reduction of risk of 18 percent. Likewise, the risk of new myocardial infarction and the risk of stent thrombosis were also reduced. "Furthermore, the benefit is not solely achieved during the acute phase, the first 30 days after angioplasty, but the benefit accrues over time so that the longer you treat, the greater the difference in event rates," Steg said. "There is a strong rationale to prefer this new agent both in the acute (first 30 days) and in the late phase after a heart attack."

Study funded by: AstraZeneca (manufacturer of the investigational drug).

Co-authors are: Richard C. Becker, M.D.; Christopher P. Cannon, M.D.; Hakan Emanuelsson, M.D., Ph.D.; Robert A. Harrington, M.D.; Jay Horrow, M.D.; Steen Husted, M.D., D.Sc.; Hugo Katus, M.D.; Robert F. Storey, M.D., D.M.; Lars C. Wallentin, M.D., Ph.D.

Disclosures: Research grant: Sanofi-Aventis, Servier Speakers bureau: Boehringer-Ingelheim, BMS, GSK, Medtronic, Sanofi-Aventis, Servier, The Medicines Company. Consulting/advisory board: Astellas, AstraZeneca, Bayer, Boehringer-Ingelheim, BMS, Endotis, GSK, Medtronic, MSD, Nycomed, Sanofi-Aventis, Servier, and The Medicines Company.

Statements and conclusions of study authors that are presented at American Heart Association scientific meetings are solely those of the study authors and
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SOURCE American Heart Association
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