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American Heart Association/American College of Cardiology Joint Science Advisory: AHA/ACC Issue Advisory on Diabetes Drugs and Heart Risk
Date:2/23/2010

60;However, patients who have successfully achieved recommended HbA1c control on a TZD might consider remaining on their medication.  If the treating physician and/or the patient is uncomfortable with using a TZD, another medication could be substituted.  There is currently not enough data to support the choice of a specific TZD.

According to the joint advisory:

  • Diabetes mellitus is increasing in prevalence in the United States and worldwide.  An estimated 23.6 million people in the United States, 7.8% of the population, had diabetes in 2007, with more than 90% of cases being type 2 diabetes mellitus.
  • Diabetes increases the risk of CVD events by 2- to 4-fold, and CVD accounts for nearly two thirds of deaths among diabetic patients.
  • Among people who experience CVD events, diabetes is highly prevalent: 45% of those hospitalized for heart attack have known or previously undiagnosed diabetes.
  • Diabetes is also an independent predictor of secondary adverse events, such as reinfarction, heart failure, and death.


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SOURCE American Heart Association
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