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American College of Gastroenterology Releases Evidence-Based Systematic Review on Management of Irritable Bowel Syndrome and Chronic Idiopathic Constipation
Date:8/5/2014

a poorly absorbed antibiotic, has moderate evidence in support of effectiveness in IBS with diarrhea.
  • Linaclotide and lubiprostone have strong recommendations for IBS with constipation.
  • There is better evidence than in the past to support the use of antidepressants and psychological therapies in IBS.
  • Highlights of ACG's New Recommendations on CIC Therapies

    • Fiber supplements are given a strong recommendation for use in CIC.
    • Laxatives—including polyethylene glycol (PEG), lactulose, sodium picosulfate and bisacodyl—have strong recommendations for the treatment of CIC.
    • Prucalopride, lubiprostone and linaclotide have been given strong recommendations for treatment of CIC.

    "This new meta-analysis of the literature on the management of IBS and chronic idiopathic constipation offers physicians scientifically-based guidance to make clinical decisions about these conditions based on a thorough assessment of the evidence," said Lawrence R. Schiller, MD, FACG, who is also a member of the ACG Functional Bowel Disorders Task Force.  "However, it is important that patients talk with their doctors about their treatment options, as there is no one-size-fits-all approach to managing IBS or chronic constipation. It's also vital that patients not be embarrassed to talk openly about their symptoms with their doctor in order to collaboratively determine the best treatment plan for their individual situation."

    About IBS
    For the clinical gastroenterologist, IBS is one of the most commonly seen digestive problems.  IBS is characterized by abdominal discomfort associated with altered bowel function; structural and biochemical abnormalities are absent. The pathophysiology of IBS is multi-factorial.  Individual symptoms have limited accuracy for diagnosing IBS, and the disorder is considered as a symptom com
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    SOURCE American College of Gastroenterology
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