Navigation Links
Ambrx Enters FGF-21 Type 2 Diabetes Drug Discovery Collaboration with Merck and Co. Inc.
Date:12/18/2007

SAN DIEGO, Dec. 18 /PRNewswire/ -- Ambrx Inc. today announced that it has entered into a global, strategic collaboration with Merck & Co. Inc. to develop a novel therapeutic protein with biological properties similar to Fibroblast Growth Factor 21 (FGF-21) for the treatment of type 2 diabetes and related metabolic disorders such as obesity.

The collaboration utilizes Ambrx's proprietary protein technology, ReCODE(TM), to develop a chemically modified and optimized drug candidate designed to have improved therapeutic properties over the native FGF-21 protein.

"We are pleased to enter into this agreement with Merck, a world leader in the metabolic diseases field with a proven track record in the rapid development and launch of diabetes medicines," said Stephen W. Kaldor, Ph.D., Ambrx's president and chief executive officer. "We are excited about the potential of our initial FGF-21 protein drug candidates, as they promise unique pharmacological efficacy in the treatment of diabetes, a disease of large and rapidly increasing prevalence."

"Molecules capable of mimicking the biological properties of the natural protein FGF-21 represent promising candidates for the treatment of metabolic disorders such as type 2 diabetes and obesity," said Luciano Rossetti, M.D., senior vice president and franchise head, Diabetes/Obesity and Cardiovascular Franchises at Merck. "Ambrx has developed several novel preclinical protein therapeutic candidates designed to provide enhanced therapeutic properties that may complement our portfolio of products for people with metabolic disorders."

The transaction includes an initial upfront payment in addition to committed R&D payments. Ambrx will also be eligible to receive future milestone payments associated with research, development and commercialization of a drug candidate resulting from the collaboration along with royalties on net sales. Ambrx also has the right to exercise an "end of Phase II" profit sharin
'/>"/>

SOURCE Ambrx Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Kosans Motilin Receptor Agonist, Licensed to Pfizer, Enters Phase 1 Clinical Trial in Gastroesophageal Reflux Disease
2. The Heart, Diabetes, And Weight Loss Centers of New York Introduce the New Science of Metabolic Diagnosis and Weight Management
3. CellCyte Genetics Corp. Enters Collaborative Research Agreement With Cleveland Clinic Foundation to Qualify Stem Cell Delivery in Damaged Heart Tissue
4. Cepheid Announces Termination of Contract With the Centers for Disease Control and Prevention to Develop Rapid Point of Care Test for Avian Influenza
5. Preimplantation Genetic Diagnosis International Society Refutes American Society of Reproductive Medicine Opinion - States Preimplantation Genetic Screening is Beneficial When Performed in Experienced Centers
6. Concentra Medical Centers Gears Up for Flu Season to Keep Area Workforce Healthy
7. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
8. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
9. Isis Initiates Phase 1 Study of ISIS 325568 Targeting Glucagon Receptor to Treat Type 2 Diabetes
10. Diabetes Research Institute Invention Promotes Growth of Stem Cells into Insulin-Producing Cells
11. Cleveland Clinic Study Shows the Diabetes Drug Pioglitazone Reduces Risk of Death, Heart Attack and Stroke, but Increases Risk of Heart Failure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... May 22, 2015  BioLife Solutions, Inc. (NASDAQ: BLFS ... grade hypothermic storage and cryopreservation freeze ... and tissues ("BioLife" or the "Company"), announced that the Company ... The Company is scheduled to present at ... 2015 at the Grand Hyatt Hotel in New ...
(Date:5/22/2015)... , May 22, 2015 The leading ... $13 billion global cardiac rhythm management device market ... found that Medtronic, St. Jude Medical, Boston Scientific ... of this market segment. The healthcare market research ... , uses 2015 as a base year, providing ...
(Date:5/22/2015)... NEW YORK , May 22, 2015 /PRNewswire/ ... approval of Zarxio (filgrastim-sndz) -- the first biosimilar ... -- points toward growth in the ... Information. The mainstream CMO industry is geared to ... infrastructure to produce major biopharmaceutical products. The healthcare ...
Breaking Medicine Technology:BioLife Solutions To Present At The 2015 Marcum MicroCap Conference In New York City 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 3Kalorama: Top Companies Dominate Cardiac Defibrillator Market 4Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 2Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 3Kalorama: First FDA-Approved Biosimilar Brings Hope for CMO Growth 4
(Date:5/22/2015)... FL (PRWEB) May 22, 2015 DMG ... Begley, Jr., scheduled to broadcast on Friday, May 29, ... via Discovery Channel. , In this episode Innovations will ... get back to business quickly through disaster recovery and ... a company that works collaboratively to develop and deliver ...
(Date:5/22/2015)... AZ (PRWEB) May 22, 2015 In ... Olympics, Parker and Sons is offering to donate $5 ... installing an AC unit or water softening system. Customers ... behalf; Parker and Sons gets business; and the Special ... , The Special Olympics helps over 4.4 million athletes, ...
(Date:5/22/2015)... 22, 2015 In April 2006, Veatch ... past 9 years they have concentrated their focus to ... and Canada. Because of this growth and their goals ... offices in Denver, Colorado, Cleveland, Ohio, Houston, Texas and ... opening new dental offices, dental start ups, orthodontic practices, ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 A new ... featuring experts in the field of Physical Therapy. ... that takes the mystery out of physical therapy and ... range of motion for a variety of ailments and ... establish a personalized exercise plan that enhances daily activities ...
(Date:5/22/2015)... Portland, Maine (PRWEB) May 22, 2015 ... in single-use swabs for the medical, diagnostic, environmental, ... their entire line of products in the US. ... moving their operations outside the US, Puritan remains ... of products at their Guilford, Maine facility. , ...
Breaking Medicine News(10 mins):Health News:New Episode of Innovations Airing Friday, May 29, 2015 Via Discovery Channel 2Health News:Parker and Sons is Proud to Support the Special Olympics with Their Everybody Wins Program 2Health News:Maine Swab Company Celebrates 96 Years of American-made Products 2
... Corp., a subsidiary of Speedus Corp. (Nasdaq: SPDE ... SI ), today announced that is has been ... development of medical diagnostic support software and related peripherals ... , Zargis has identified the handheld environment as a ...
... Will Speed Veterans, Appeals , WASHINGTON Oct. 21 ... addition of four new Veterans Law Judges to the Board ... increase the number of cases being decided. , "Veterans have ... their claims for benefits," Secretary Shinseki said. "This expansion of ...
... YORK, Pa., Oct. 21 LearntobeHealthy.org, a ... Byrnes Health Education Center, has added new online curriculum ... as stress management, bullying and cyber-bullying, maintaining healthy relationships, ... The new online kit, titled "Face the Music," informs ...
... trainees who hope to translate laboratory research into clinical medicine ... Science Careers, and Science are launching ... been designed to serve two distinct groups: CTSciNet ... translational research, and MySciNet is a network focused ...
... Lowering Estrogen ... ... founded in 2002 to naturally treat women and men suffering from hormone imbalances, has organized ... Each step is designed to keep breast tissue healthy by eliminating estrogen dominance, a medical ...
... study needed into how CRP levels influence risk , WEDNESDAY, ... protein (CRP) may increase a person,s risk for heart attack ... found. , The study included 2,240 people in New York ... start of the study, the participants, blood was checked for ...
Cached Medicine News:Health News:Zargis Cleared as Apple iPhone Developer; Medical Applications for Smartphones Planned 2Health News:Secretary Announces Expansion of Veterans Appeals Board 2Health News:LearntobeHealthy.org Adds Mental Health Curriculum for Teens 2Health News:AAAS and partners debut new online networks for clinical and minority scientists 2Health News:AAAS and partners debut new online networks for clinical and minority scientists 3Health News:AAAS and partners debut new online networks for clinical and minority scientists 4Health News:AAAS and partners debut new online networks for clinical and minority scientists 5Health News:Steps Every Woman Must Take to Prevent Breast Cancer from the Natural Hormone Institute 2Health News:Steps Every Woman Must Take to Prevent Breast Cancer from the Natural Hormone Institute 3Health News:Steps Every Woman Must Take to Prevent Breast Cancer from the Natural Hormone Institute 4Health News:Steps Every Woman Must Take to Prevent Breast Cancer from the Natural Hormone Institute 5Health News:Blood Protein May Predict Heart Attack But Not Stroke 2
... Blood Collection Sets allow you to ... safety. The BD Vacutainer® Safety-Lok™ Blood ... be shielded with one-handed activation. This ... and infusion procedures. It comes with ...
Safety Blood Collection Sets are supplied in three packaging variations, either with or without Luer Adapter and respectively a version with Luer Adapter and Tube Holder....
... provides the capability to change ... of surgery while retaining exposure ... The system is also strong ... large patients while remaining nimble ...
These retractors are packaged singly ready for sterilization at your facility....
Medicine Products: