Navigation Links
Ambit Biosciences and Teva Announce Clearance of an Investigational New Drug (IND) Application for CEP-32496, A Novel BRAF(V600E) Inhibitor
Date:5/17/2012

SAN DIEGO and JERUSALEM, May 17, 2012 /PRNewswire/ -- Ambit Biosciences and Teva Pharmaceutical Industries Limited (NASDAQ: TEVA) ("Teva") today announced the clearance of an Investigational New Drug application (IND)  with the U.S. Food and Drug Administration (FDA) for CEP-32496, a novel BRAF (V600E) kinase inhibitor. 

The IND filing was based upon promising therapeutic potential for this agent, as evidenced by data revealed in recent publications in the Journal of Medicinal Chemistry and Molecular Cancer Therapeutics characterizing the preclinical properties of CEP-32496. The two publications feature results that demonstrate CEP-32496 is a selective and potent inhibitor of BRAF (V600E) in cells.  The published preclinical findings also demonstrate that CEP-32496 possesses potent and sustained anti-tumor activity in xenograft models of melanoma and colon carcinoma.  CEP-32496 possesses attractive pharmacokinetic properties upon oral administration and benchmarks favorably with respect to other kinase inhibitors that have activity at the BRAF (V600E) mutated kinase. 

"The data that we have generated to date in these preclinical studies lead us to believe that we have a promising drug candidate with CEP-32496 and is further validation of our successful drug discovery collaboration with Ambit," said Bruce Ruggeri, Ph.D., Senior Director, Oncology and Inflammation Discovery Research of Teva. "We look forward to exploring the full potential of this drug candidate to improve outcomes in patients with tumors possessing the BRAF(V600E) mutation."

Added Michael A. Martino, Ambit's President and Chief Executive Officer, "The filing of this IND represents a significant milestone for the Teva-Ambit coll
'/>"/>

SOURCE Ambit Biosciences
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Ambit Biosciences to Present at 30th Annual J.P. Morgan Healthcare Conference
2. Ambit Biosciences Initiates Two Phase I Clinical Trials
3. Ambit Biosciences Strengthens Board of Directors and Executive Team
4. Ambit Biosciences Files Registration Statement for Proposed Initial Public Offering
5. Ambit Biosciences and Astellas Enter Strategic Partnership to Research, Develop and Commercialize FLT3 Kinase Inhibitors in Multiple Indications
6. Ambit Biosciences Corporation Presents Phase I Clinical Results of AC220 in Patients With Acute Myeloid Leukemia at ASH Conference
7. Ambit Biosciences Corporation Announces Presentations Profiling AC220 Clinical and Non-Clinical Data at 51st American Society of Hematology Annual Meeting
8. Pressure BioSciences, Inc. to Discuss First Quarter 2012 Financial Results And Provide Business Update
9. Neurocrine Biosciences Reports First Quarter 2012 Results
10. Amarantus BioSciences to Present at the New York Biotechnology Association (NYBA) 21st Annual Meeting on May 2nd, 2012
11. Neurocrine Biosciences Announces Conference Call and Webcast to Present First Quarter 2012 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... Allowing more basic emergency medical service (EMS) staff to ... opioids, according to a Centers for Disease Control and ... Medical Service Providers and the Burden of Drug Overdose ... of Public Health . In 2013, more ... involved prescription opioids, and more than 8,000 ...
(Date:4/24/2015)... 24, 2015 In today,s ever-changing and ... around the world to access diverse skill sets, ... there are many areas to misstep in the ... best practices are necessary and beneficial in order ... According to research by benchmarking firm, Best Practices, ...
(Date:4/24/2015)... , Apr. 24, 2015 Research and ... announced the addition of the "Lab ... tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station) & End User ... Global Forecast to 2020" report to ... accessories market is expected to reach $504.7 ...
Breaking Medicine Technology:Expanding Naloxone use could reduce drug overdose deaths and save lives 2Expanding Naloxone use could reduce drug overdose deaths and save lives 3Work Around the Clock: Building Effective Global Capabilities 2Global Lab Accessories Market Report 2015-2020 - Label Printer/ Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station 2Global Lab Accessories Market Report 2015-2020 - Label Printer/ Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station 3
... SILVER SPRING, Md., May 13, 2011 The U.S. Food ... represented as "ExtenZe," which is the name of an authentic ... similar to the actual product, but contains hidden ingredients that ... the following lot numbers on the packages: ...
... 13, 2011 Amnis Corporation, a manufacturer of advanced ... new FlowSight imaging flow cytometer. The FlowSight ... unrivalled fluorescence sensitivity and the breakthrough ability to produce ... upgraded in the factory or the field with up ...
Cached Medicine Technology:FDA Warns About Counterfeit ExtenZe Dietary Supplements 2
(Date:4/25/2015)... Carinsurancequotesinfo.com has released a new blog ... auto insurance for flatbed trucks. , Flatbed ... other vehicles. They are mainly used for commercial purposes ... blog post explains that by comparing multiple offers, drivers ... other commercial vehicles. , It is now possible to ...
(Date:4/25/2015)... (PRWEB) April 25, 2015 Parker and Sons ... and cooling, has spiked in Arizona alongside the growing economy. ... additional forty employees for April to help account for the ... forty employees in April is something we are enthusiastic about. ... said Paul Kelly, president at Parker and Sons. , Indeed, ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 Bird B Gone, ... residential applications now offers a complete line of bird control ... poultry farms. , New Flu Strains Threaten Pacific, Central and ... USDA post , a number of highly pathogenic avian ... The disease is often spread when wild birds enter poultry ...
(Date:4/24/2015)... 24, 2015 Carvers' goal is ... a successful biking day in Breck. , Conveniently ... minutes walking distance from Breckenridge, this family-owned place ... both Breckenridge bike rentals ( http://www.breckenridgeskishop.com/en/rent-equipment ) and ... extensive bike rentals in May 2015. With style ...
(Date:4/24/2015)... 24, 2015 The first step to ... mind. , For meditation and yoga teacher Stine Koppernæs, ... been invaluable tools that allow her to experience more ... has been a teacher since 2006, and through the ... state of being. , “I love sharing this way ...
Breaking Medicine News(10 mins):Health News:Auto Insurance Quotes for Flatbed Trucks Available Online! 2Health News:Parker and Sons Plans to Expand in 2015 2Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 2Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 3Health News:Bird B Gone Offers Solutions to Bird Flu Threat to Poultry Farms 4Health News:Carvers Breckenridge Bike Rentals Offers Demo Mountain, Tandem, Bike Path Cruiser & JR. Bikes in May 2015 2
... of "Breast Ironing" in West African countries. This practice ... in girls by mothers// and other relatives telling them that ... aimed at warding off sexual harassment and is carried out ... in teenaged girls. "Breast ironing is an age-old practice in ...
... introduce new legislation to regulate doctors, due to be published ... Government approval in order to publish heads of bill for ... a new Medical Practitioners Bill can be published later this ... have been promised and postponed for many years, it is ...
... the most dreaded of all the communicable diseases ... be controlled through effective dog population management and ... Chief Minister Ghulam Nabi Azad today said. ... and post-exposure prophylaxis, dog population management and laboratory ...
... US scientist they have found a new technique to detect ... ,As of now they were successful in detecting infection ... further research is needed to identify the disease in humans. ... this disease appears to have been transmitted by blood transfusions. ...
... for the betterment of the lives of thousands of ... a growing concern about the need for specialists// and ... the National Rheumatoid Arthritis Society and Arthritis Care have ... funds available to access new treatments official guidelines, along ...
... and other staff at AIIMS have decided to continue ... ,The governments order on relieving the Director of AIIMS ... the faculty, doctors, and other staff members of the ... across the state and nation. Meanwhile one representative each ...
Cached Medicine News:Health News:Campaign For Arthritis Awareness Launched In Scotland 2Health News:AIIMS Strike Enters Second day, Support Continues To Pour In 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: