Navigation Links
Ambit Biosciences Initiates Two Phase I Clinical Trials
Date:12/20/2010

SAN DIEGO, Dec. 20, 2010 /PRNewswire/ -- Ambit Biosciences (Ambit), today announced that it has initiated separate Phase I trials for two products AC430, a selective Janus Kinase 2 (JAK2) inhibitor, and AC480, a pan-HER inhibitor.

The Phase I trial for AC430 is a two part, placebo-controlled, single ascending, and multiple ascending dose trial in healthy volunteers.  AC430 will be administered orally once-daily and doses escalated until a maximum tolerated or maximum feasible dose is established.  In addition to evaluating the safety, tolerability, and pharmacokinetics of AC430, the study will also assess cytokine signal transduction.  

The Phase I trial for AC480 is a multi-center, dose escalation study with AC480 administered by intravenous infusion on days one and two of a 21 day cycle, either alone or in combination with docetaxel.  The trial will assess safety, pharmacokinetics and anti-tumor activity of AC480 in patients with advanced solid tumors.

"The initiations of these studies are important milestones," said Alan Lewis, President and CEO Ambit Biosciences. "AC430 has demonstrated convincing efficacy in pre-clinical models of autoimmune and inflammatory diseases, and AC480 IV was developed to assess whether pulsatile doses of a pan-HER inhibitor administered in combination with a taxane such as docetaxal would produce synergistic anti-tumor activity."

About AC430AC430 was specifically developed to be a best-in-class JAK2 inhibitor.  In preclinical studies, AC430 has exhibited potency against JAK2 in cell-based models that is at least equivalent, and in most cases superior to, competing JAK2 inhibitors, and also has excellent oral pharmacokinetic properties.  In preclinical oncology and autoimmune models, AC430 is well tolerated and has significant efficacy at oral doses as low as 10 mg/kg/day.  JAK2 has been implicated as a target for therapy in both oncology and autoimmune disease
'/>"/>

SOURCE Ambit Biosciences Corporation
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Ambit Biosciences Strengthens Board of Directors and Executive Team
2. Ambit Biosciences Files Registration Statement for Proposed Initial Public Offering
3. Ambit Biosciences and Astellas Enter Strategic Partnership to Research, Develop and Commercialize FLT3 Kinase Inhibitors in Multiple Indications
4. Ambit Biosciences Corporation Presents Phase I Clinical Results of AC220 in Patients With Acute Myeloid Leukemia at ASH Conference
5. Ambit Biosciences Corporation Announces Presentations Profiling AC220 Clinical and Non-Clinical Data at 51st American Society of Hematology Annual Meeting
6. Catalyst Biosciences Receives Milestone Payment from Pfizer for Progress in Lead Hemostasis Program
7. Cell Biosciences Announces US Patent Issuance
8. Sofie Biosciences Raises $2M to Support Development of Diagnostic Imaging Agents and Devices
9. Sangamo BioSciences Announces Presentation of Phase 2 Data in Amyotrophic Lateral Sclerosis (ALS) at Society for Neuroscience Meeting
10. Regado Biosciences, Inc. Introduces REG3, a Novel Aptamer-Based Inhibitor of Glycoprotein VI and its Matched Active Control Agent, at the American Heart Association (AHA) Scientific Sessions 2010 Meeting
11. Cardio3 BioSciences Announces Positive Outcome of the C-Cure(R) Phase II Clinical Trial in Heart Failure Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , December 17, 2014 Revenue ... of expenditure on research and development In the ... its revenue by two percent to EUR 4.287 billion (last ... grew by 14 percent to EUR 360 million. "Overall, 2013/14 ... Dr. Michael Kaschke , President and CEO of Carl ...
(Date:12/17/2014)... Dec. 17, 2014  Northstar Global Business Services, ... Company (DTC) has made their final decision and ... the Company,s stock effective December 15, 2014, and ... for depository and book entry transfer services. All deposit ... now once again fully "DTC Eligible", and has ...
(Date:12/17/2014)... , Dec. 17, 2014  Beamz Interactive, Inc. ... music products, today announced that it has signed ... manufacturer and supplier of innovative prosthetic, orthotic and ... part of the agreement, RSL Steeper will promote ... specifically configured for use within UK residential care ...
Breaking Medicine Technology:ZEISS Asserts its Position in Difficult Environment 2Northstar announces that the DTC chill on MDIN has been officially lifted 2Northstar announces that the DTC chill on MDIN has been officially lifted 3Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 3
... , , NEW YORK , ... is a new online, print and print-on-demand publication from LIVE STRONG ... fight against cancer; resources and information about cancer prevention and treatment; ... a three-time cancer survivor, I understand the worries and concerns other ...
... , SAN DIEGO , Feb. 9 ... developer and manufacturer of precision intravascular therapy guidance tools designed ... vascular disease, announced today that it has received 510(k) clearance ... the Eagle Eye® Platinum digital IVUS catheter in the ...
Cached Medicine Technology:SPOT ON media and LIVESTRONG(R) Launch LIVESTRONG Quarterly 2SPOT ON media and LIVESTRONG(R) Launch LIVESTRONG Quarterly 3SPOT ON media and LIVESTRONG(R) Launch LIVESTRONG Quarterly 4Volcano Receives FDA Clearance to Market the Eagle Eye(R) Platinum Digital IVUS Catheter 2Volcano Receives FDA Clearance to Market the Eagle Eye(R) Platinum Digital IVUS Catheter 3Volcano Receives FDA Clearance to Market the Eagle Eye(R) Platinum Digital IVUS Catheter 4
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
... Coalition embarks on "Drive for 3.5" in celebration of National Donate Life ... ... 1, 2008 In celebration of April being,National Donate Life Month, Donate ... 30 seconds to register in the,state,s new organ/tissue donor registry and help ...
... Denny Chipollini inspires others to hit the trails for ... Valley Forge Revolutionary 5-mile Run, ... people would,consider tragedies, 55-year-old Skippack, Pa., resident Denny Chipollini,considers gifts. ... of his leg in a near-fatal car accident and the,contraction ...
... Va., April 1, 2008 The following,is being ... Diabetes Association,s 68th Annual Scientific Sessions., WHEN: ... Moscone Center, San Francisco, CA, WHY: More ... care,professionals from around the world will share cutting-edge ...
... ... Position, ... of product safety testing services,announced today that its Management System Solutions ... party management,system certification services headquartered in Frankfurt am Main, Germany., ...
... Va., April 1, 2008 BurgessGroup,a leading Medicare-based ... signing of a three-year contract renewal with,CalOptima, a ... County,California-based public agency created by the state of ... five County Organized Health Systems (COHS) in the,country, ...
... Do humans hear better than animals? It is known ... are capable of hearing some lower and higher frequencies ... the Hebrew University of Jerusalem and elsewhere have now ... single neurons give humans the capability of detecting fine ...
Cached Medicine News:Health News:Illinoisans Called Upon to Register as Organ & Tissue Donors in Final Push to Reach Campaign Registration Goal 2Health News:Illinoisans Called Upon to Register as Organ & Tissue Donors in Final Push to Reach Campaign Registration Goal 3Health News:For Inspiring Amputee It's No Excuses, No Limits 2Health News:Underwriters Laboratories' Management System Registration Business to Merge With Germany's DQS 2Health News:BurgessGroup Announces Contract Renewal and Software Upgrade by CalOptima 2Health News:Humans have more distinctive hearing than animals, Hebrew U study shows 2
Tapered Shaft Microscissors : Williams Curved SharpTipped Scissors...
Disposable Microscissors: Horizontal, Curved...
Disposable Microscissors: Horizontal, Straight...
Disposable Microscissors: Vertical, 90...
Medicine Products: