Navigation Links
Ambit Biosciences Corporation Presents Phase I Clinical Results of AC220 in Patients With Acute Myeloid Leukemia at ASH Conference
Date:12/7/2009

SAN DIEGO, Dec. 7 /PRNewswire/ -- Ambit Biosciences Corporation announced today that preliminary results from a clinical trial of its lead product candidate, AC220, in acute myeloid leukemia (AML) were presented at the 51st Annual Meeting of the American Society of Hematology (ASH) in New Orleans. AC220 is a novel, orally available, small molecule that was expressly optimized as a FMS-like tyrosine kinase-3 (FLT3) inhibitor for the treatment of AML.

The open-label, dose-escalation study, "AC220, a Potent, Selective, Second Generation FLT3 Receptor Tyrosine Kinase Inhibitor, in a First-in-Human Phase I AML Study," was designed to evaluate the safety, tolerability, and pharmacokinetic profile of AC220 in AML patients with predominantly relapsed or refractory disease. AC220 was generally well-tolerated in AML patients, and importantly, there was no treatment-related mortality observed in this study. Clinical response and median survival were assessed as secondary endpoints and analyzed for the overall study population, in addition to patient subsets based on the presence or absence of the FLT3 genotype for the internal tandem duplication (ITD) mutation (FLT3 ITD+ and FLT3 ITD-, respectively). Following treatment with AC220, responses were observed in both FLT3 ITD+ and FLT3 ITD- patients, and responders in each group had at least a doubling in median survival versus non-responders.

"AML represents a challenging hematological malignancy to treat. A significant portion of AML patients have activating FLT3 mutations, and these patients have a particularly poor prognosis and are often refractory to current treatment options," said Jorge Cortes MD, Internist and Professor, Deputy Chair, Department of Leukemia, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, and primary investigator for the Phase I Study. "These encouraging results with AC220 warrant further studies of this promising
'/>"/>

SOURCE Ambit Biosciences Corporation
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Ambit Biosciences Corporation Announces Presentations Profiling AC220 Clinical and Non-Clinical Data at 51st American Society of Hematology Annual Meeting
2. ImmuneRegen BioSciences Reports Material Transfer Agreement with VaxGen, Inc.
3. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
4. Upstream Biosciences Acquires Innovative Platform Technology and Drug Candidates for Tropical Parasitic Diseases
5. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
6. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
7. Ardea Biosciences Lead MEK Inhibitor, RDEA119, to Enter Human Clinical Trials in Advanced Cancer Patients
8. Alacrity Biosciences Announces Positive Results from a Phase 2 Study of Its Dry Eye Treatment ALTY-0501
9. Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
10. Regado Biosciences Initiates Phase IIa Clinical Study of REG1 Anticoagulation System
11. Regado Biosciences Presents Positive Data From REG1 Anticoagulation System Phase Ic Study at American Heart Association 2007 Scientific Sessions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... 2013 STAAR Surgical Company (NASDAQ: ... minimally invasive ophthalmic products, today announced that it will ... Company,s recent financial results and business developments with investors ... at the 38 th Annual Deutsche Bank 2013 ... the Westin Waterfront Hotel on Wednesday, May 29, 2013 ...
(Date:5/21/2013)... Va. , May 21, 2013   ... 22,000 pharmacies nationwide, announces today the publication of ... America,s Post-Reform Health Care System. The white paper ... reducing costs, and seeks public engagement to avert ... Personalized Pharmacist Care refers to a range of ...
(Date:5/20/2013)... May 20, 2013  Volcano Corporation (NASDAQ: ... guided therapy tools designed to enhance the diagnosis and ... it will highlight its efforts to expand research and ... Reserve (FFR) and iFR ® (Instant Wave-Free Ratio™) ... and events at EuroPCR 2013 in Paris ...
Breaking Medicine Technology:STAAR Surgical To Present At Upcoming Investor Conferences 2RxAlly Releases White Paper on Necessity of Personalized Pharmacist Care 2RxAlly Releases White Paper on Necessity of Personalized Pharmacist Care 3Volcano to Highlight its Physiology Expansion Efforts at EuroPCR 2013 2Volcano to Highlight its Physiology Expansion Efforts at EuroPCR 2013 3Volcano to Highlight its Physiology Expansion Efforts at EuroPCR 2013 4
... our ability to target experimental cancer treatments ... hand, and more are on the way ... drugs, MILAN, Italy, April 27 , At today,s ... Meeting,of the European Association for the Study of the Liver ...
... Virology Translate Into New Promising Drugs to Combat Hepatitis ... ... Stem Cells of Potential Benefit in Liver ... Liver Diseases, At today,s sessions of the 43rd Annual Meeting of the European,Association ...
Cached Medicine Technology:Molecular Discoveries Shed Light on Liver Cancer -- Hepatocellular Carcinoma (HCC) 2Molecular Discoveries Shed Light on Liver Cancer -- Hepatocellular Carcinoma (HCC) 3Basic Science Discoveries Yield Progress in Hepatology 2Basic Science Discoveries Yield Progress in Hepatology 3Basic Science Discoveries Yield Progress in Hepatology 4
(Date:5/21/2013)... Reporter , , TUESDAY, May 21 (HealthDay News) -- Pregnant ... at increased risk of suffering depression after giving birth, ... they can use the findings to develop a blood ... vulnerable to postpartum depression, which affects around 15 percent ... May 21 issue of the journal Molecular Psychiatry ...
(Date:5/21/2013)... Pathways Home Health, Hospice & ... remember and honor a loved one in the company ... Sunday, June 2, 2013, 3-4 pm at Skylawn Memorial ... CA 94402. , The Pathways Hospice Evening of Remembrance ... with music, readings and support. Open to the public ...
(Date:5/21/2013)... obese patients are significantly more likely than their ... a practice that disrupts continuity of care and ... Hopkins research suggests. , The practice of "doctor ... of negative experiences with the health care system, ... unsolicited weight loss advice by providers, or improperly ...
(Date:5/21/2013)... STAR (Sensory Therapies And Research) ... sensory challenges and the Sensory Processing Disorder (SPD) ... advocacy of Sensory Processing Disorder present Stumbling Blocks into ... Quality of Life, a two-hour lecture presented by guest ... , Learn a method that can aid in identifying ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 Diehard soccer fans ... powerhouse teams - the game between Manchester City ... of May 2013. These two teams are highly decorated ... are bringing their A-game to the Busch Stadium, home of ... will be the first time that a professional sporting event ...
Breaking Medicine News(10 mins):Health News:Genes May Boost Woman's Risk of Postpartum Depression 2Health News:Genes May Boost Woman's Risk of Postpartum Depression 3Health News:Hospice Offers Evening of Remembrance Memorial Service in San Mateo, California 2Health News:'Doctor shopping' by obese patients negatively affects health 2Health News:'Doctor shopping' by obese patients negatively affects health 3Health News:STAR Center and SPD Foundation Present a Lecture on Teens and Adults with Sensory Processing Disorder 2Health News:STAR Center and SPD Foundation Present a Lecture on Teens and Adults with Sensory Processing Disorder 3Health News:Manchester City vs. Chelsea FC Tickets: Cheap Concert Tickets has Slashed Prices on Manchester City vs. Chelsea FC Tickets at Busch Stadium in St. Louis, MO 2
... ... advocating for physician patient relationships which ensure optimal patient care and well being, the ... such as breast cancer screening that can negatively impact patients. , ... (PRWEB) January 17, 2010 -- The ...
... LOS ANGELES , Jan. 16 In order ... Employees International Union (SEIU) has entered into an alliance with International ... , As many as 600 SEIU members, many of them Haitian ... part of an emergency response in Haiti . SEIU Healthcare ...
... , ... Latin America , WASHINGTON , Jan. 16 ... Haiti relief efforts using a new Portuguese website called ... of American States announced. , AjudaPanamericana.org is the third language option ...
... , American Red Cross President & CEO ... , WASHINGTON , Jan. 16 ... today and thousands of responders are traveling the streets, providing water ... transporting people with serious injuries to nearby health facilities. , ...
... ... to announce the launch of their new online store, featuring free shipping and the guaranteed ... ... 4 Home Superstore, is pleased to announce the launch of their new online store, featuring ...
... ... available for purchase online and from many UK hot tub stores. Splash Spas has ... in China by a leading inflatable products manufacturer, Oriental Recreational Products Corporation. , ... (PRWEB) January 16, 2010 -- Many consumers ...
Cached Medicine News:Health News:Southern Medical Association Takes Position on Breast Cancer Screening 2Health News:Southern Medical Association Takes Position on Breast Cancer Screening 3Health News:Southern Medical Association Takes Position on Breast Cancer Screening 4Health News:International Medical Corps Partners with Service Employees International Union to Provide Aid to Haiti's Earthquake Survivors 2Health News:Haiti Relief Site Now in Portuguese 2Health News:Haiti Relief Site Now in Portuguese 3Health News:Red Cross Aid Reaches Haitian Earthquake Survivors 2Health News:Red Cross Aid Reaches Haitian Earthquake Survivors 3Health News:Fitness4HomeOnline.com Features Fitness Equipment Online with Free Shipping and Guaranteed Lowest Price 2Health News:Web's Newest, Sub-1000 Range of Hot Tubs Now Available For Purchase Online! 2Health News:Web's Newest, Sub-1000 Range of Hot Tubs Now Available For Purchase Online! 3