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Amarantus BioSciences Reports Addition of New Scientific Articles to MANF Publications List
Date:3/19/2012

the ER increases in response to cellular stress in order to improve cell function and prevent apoptosis. In stressful conditions, MANF is also secreted out of the cell resulting in enhanced protection and survival of neighboring cells. MANF's ability to act both in the cell and outside the cell appears to be unique among ER–resident proteins. The authors demonstrate that slight variations in MANF's genetic sequence determine its ability to be secreted out of the cell and hypothesize that MANF secretion may be dependent, in part, on the level of expression of GRP78, another ER-resident chaperone protein that increases protein folding in an effort to reduce apoptosis.

"The findings reported in this well-respected scientific journal provide further understanding of the mechanisms responsible for the secretion of MANF out of the cell," said John W. Commissiong Ph.D, Chief Scientific Officer of Amarantus. "As our understanding of how MANF protects cells from death improves, we expect to see a range of disorders related to apoptosis and other mechanisms of cell death fall under the treatment purview of our proprietary, ground-breaking MANF technology."

About Amarantus BioSciences, Inc.

Amarantus BioSciences, Inc. is a development-stage biotechnology company founded in January 2008.  The Company has a focus on developing certain biologics and biomarkers surrounding the intellectual property and proprietary technologies it owns and has rights to for the treatment and diagnosis of Parkinson's disease and other human diseases.  The Company owns the intellectual property rights to an anti-apoptotic therapeutic protein known as Mesencephalic-Astrocyte-derived Neurotrophic Factor ("MANF"), and owns an inventory of 88 cell lines referred to as "PhenoGuard Cell Lines" from which MANF was discovered. The Company also has a license to the NuroPro™ diagnostic test for Parkinson's disease from Power3 Medical Products. For further
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SOURCE Amarantus BioSciences, Inc.
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