Navigation Links
Amarantus BioSciences Announces MANF Demonstrates Superiority over GDNF in Neurorestoration Behavioural Animal Model of Parkinson's Disease
Date:10/25/2012

nigra, and creating Parkinson's-like behavioural symptoms that were quantified by counting the number of times the rats turned in a circle in the same direction (behavioural deficits) in a given 120 minute period of time. MANF and GDNF were delivered directly into the substantia nigra of separate groups of rats 2 weeks following the administration of the 6-OHDA, in order to mimic as closely as possible in rats the treatment setting in humans where treatment would be administered after an extended timeframe following the initiation of dopaminergic nerve terminal retraction, each at the optimal dosing level of 10 micrograms. Four weeks following MANF treatment into the substantia nigra, behavioural deficits were reduced by ~43%, and six weeks following MANF treatment, behavioural deficits were reduced by ~53%; four weeks following GDNF treatment into the substantia nigra, behavioural deficits were reduced by ~16%, and six weeks following GDNF treatment, behavioural deficits actually increased by ~20%. 

"The data obtained in this study provide clear evidence that MANF had a strong positive and restorative effect on the behaviour of animals in this pre-clinical Parkinson's disease study when delivered to the substantia nigra, whereas GDNF had no such effect," said John W. Commissiong PhD, Chief Scientist at Amarantus and former Head of the Neurotrophic Factors Group at the National Institutes of Health. "The localization of the drug treatment in this study is critical because, as Parkinson's disease progresses, dopaminergic nerve terminals typically retract from the striatum towards their cell bodies in the substantia nigra, resulting in the disruption of the basal ganglia network that is responsible for proper motor function. Translated, the longer you have Parkinson's disease, the less likely a neurotrophic factor will work when delivered to the striatum because there are fewer dopaminergic nerve terminals remaining to act on, and so neurotrophic factor d
'/>"/>

SOURCE Amarantus BioSciences, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Amarantus BioSciences to Present at the New York Biotechnology Association (NYBA) 21st Annual Meeting on May 2nd, 2012
2. Pressure BioSciences, Inc. and Target Discovery, Inc. Expand Strategic License Agreement and Collaboration Supporting TDIs Planned Offering of Personalized Medicine Clinical Diagnostic Services
3. Neurocrine Biosciences Announces Conference Call and Webcast to Present First Quarter 2012 Financial Results
4. Neurocrine Biosciences Reports First Quarter 2012 Results
5. Pressure BioSciences, Inc. to Discuss First Quarter 2012 Financial Results And Provide Business Update
6. Ambit Biosciences and Teva Announce Clearance of an Investigational New Drug (IND) Application for CEP-32496, A Novel BRAF(V600E) Inhibitor
7. Neurocrine Biosciences to Present at the Jefferies 2012 Global Healthcare Conference
8. 3-V Biosciences To Present at the Seventh Annual JMP Securities Healthcare Conference
9. Sofie Biosciences receives $1M Phase II SBIR grant from the DOE
10. Frost & Sullivan 2012 New Product Innovation in Bioanalytics Awarded to Protea Biosciences
11. Pressure BioSciences Patented PCT Platform Shown to Significantly Improve Protein and DNA Detection in Multiple Studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 2014 According to a new ... Market (Endoscopes, Endoscopic Operative Devices, and Visualization Systems) - ... 2013-2019" the global endoscopy devices market was valued at ... grow at a CAGR of 6.8% from 2013 to ... billion in 2019. Browse the full Endoscopy ...
(Date:7/10/2014)... India , July 11, 2014  Major ... treatment of cancer are being highlighted in a ... Mumbai from 10-12 July, 2014.  Renowned national ... to share best practices and exchange knowledge on ... precise, accurate and efficient. The ...
(Date:7/10/2014)...  RESMED INC. (NYSE: RMD ) today announced ... ended June 30, 2014 results on Thursday, July 31, 2014, ... release with ResMed,s results will be issued after 1:00 p.m. ... to discuss operating results and future outlook. The ... Pacific Time and the live webcast of the call can ...
Breaking Medicine Technology:Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2
... Soligenix, Inc. (OTC Bulletin Board: SNGX ) ... today that it has appointed Kevin Horgan, MD, as ... Horgan is a board-certified gastroenterologist with a research background ... patients with inflammatory bowel disease, including graft-versus-host disease (GVHD). ...
... JOLLA, Calif., Feb. 1, 2011 Transdel Pharmaceuticals, ... a specialty pharmaceutical company focused on developing topically ... announced that the Company has been exploring strategic alternatives ... American MedTech Advisors and ESC Advisors, a division ...
Cached Medicine Technology:Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 2Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 3Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 4Transdel Pharmaceuticals Announces Exploration of Strategic Alternatives 2Transdel Pharmaceuticals Announces Exploration of Strategic Alternatives 3
(Date:7/11/2014)... (PRWEB) July 11, 2014 Global enterprises ... services to outsource day-to-day management activities. Managed services offer ... additional expenses. The economic slowdown resulted into rising operational ... and expenses is considered to be the global market ... future. , The global managed services market is estimated ...
(Date:7/11/2014)... HOUSTON (July 10, 2014) Obese and ... from their health care providers, according to new ... Center at Houston (UTHealth). , National guidelines state ... on the importance of maintaining a healthy weight. ... events are the leading cause of line-of-duty deaths ...
(Date:7/11/2014)... (HealthDay News) -- Prostate cancer patients are more likely ... treatment and die sooner if they also have depression, ... more than 41,200 American men who were diagnosed with ... them through 2009. Nearly 1,900 of the patients had ... their prostate cancer was discovered. "Men with intermediate- ...
(Date:7/11/2014)... Europe is one of the largest ... hence, irrigated land area. The agricultural sector is a ... around 30.0% of the total water use. The scale ... southern region, but far from negligible in most northern ... over 60.0% of the water use in most countries, ...
(Date:7/11/2014)... a history of hazardous or binge drinking reduced their ... mobile phone text messages following a visit to the ... in Annals of Emergency Medicine (" A ... Patients: A Randomized Clinical Trial "). , "Each day ... to 24 visit ERs and up to half have ...
Breaking Medicine News(10 mins):Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:Depression May Make It Harder to Beat Prostate Cancer 2Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 2Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 3Health News:Text message medicine: Texts from the ER can reduce binge drinking 2
... men who smoke had less risk of undergoing total joint ... that men who were overweight, or who engaged in vigorous ... this study are now available in Arthritis & Rheumatism ... College of Rheumatology (ACR). Research has shown that ...
... , THURSDAY, July 7 (HealthDay News) -- Suicide ... financial crisis, while road deaths decreased, according to researchers. ... percent relative increase) between 2007 and 2009. At the same ... in suicide rates seen in EU countries before 2007. ...
... belief, so-called hypoallergenic dogs do not have lower household allergen ... study by Henry Ford Hospital researchers who sought to evaluate ... home than other dogs. Hypoallergenic dogs are believed to produce ... findings are to be published online this month in the ...
... and treatment of pediatric leukemia at St. Jude Children,s Research ... M. Stratton Medal from the American Society of Hematology (ASH). ... fight against this blood cancer during the past three decades. ... of Grune and Stratton, the medical publishing house that first ...
... be reached in time to avert an unprecedented suspension of ... Medicaid and other federal health programs," Virginia Hood, MBBS, ... told the president, vice president and Congressional leaders today. ... legislation to increase the debt ceiling linked to an agreement ...
... Kathleen Doheny HealthDay Reporter , THURSDAY, July ... dignity therapy helped terminally ill patients improve their quality ... changing how their family sees and appreciates them, according ... however, ease those distressed by dying, as the researchers ...
Cached Medicine News:Health News:Male smokers less likely to need joint replacement surgery of hip or knee 2Health News:Europe's Suicides Up, Road Deaths Down After Economy Tanked 2Health News:Study: Hypoallergenic dogs not less allergic than other dogs 2Health News:Ching-Hon Pui, M.D., honored by the American Society of Hematology for work in childhood cancer 2Health News:Debt ceiling agreement 'essential' to prevent disruption of care for Medicare & Medicaid patients 2Health News:Debt ceiling agreement 'essential' to prevent disruption of care for Medicare & Medicaid patients 3Health News:Special Talk Therapy Seems to Help Dying Patients 2Health News:Special Talk Therapy Seems to Help Dying Patients 3
... 10.1 kg, Interior Dimensions (WxDxH): 31.1 x ... (WxDxH): 44.6 x 22.4 x 20.5 cm, ... 2 - 300 x 35 mm bottles, ... or 1 - 240 x 80 mm ...
... four basic components: sample well plate, filter support ... diagram). The sample well plate is available in ... (see below). All three plates are interchangeable and ... conjunction with a complete system. The tension on ...
... SF (slot format) microfiltration units provide a ... acid in solution onto nitrocellulose or Zeta-Probe ... by using interchangeable templates to form the ... Bio-Dot SF apparatus. Each is available as ...
Dot Blotter - 96-Well Dot Blot...
Medicine Products: