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Alzheimer's Reviewed by NeuroPerspective
Date:9/3/2014

ng devoted to alternative upstream models, and to downstream access points that may be relevant to multiple neurodegenerative disorders.

  • A review of the many therapeutic strategies that have been employed, and that are currently under development, with a fresh focus upon tau and anti-inflammatory approaches.

  • The companies and programs that are in clinical, preclinical, and discovery stage. Over 230 therapeutic programs are included in this review. The issue includes assessments of continued efforts to find an effective antibody strategy, and the continuing trend towards the omission of Phase IIb testing.
    • The issue also focuses upon variations on the secretase theme from Merck, AstraZeneca, Forum Pharmaceuticals and Novartis; beta-amyloid targeting alternatives from companies like Acumen, Axerion/AstraZeneca, American Life Science Partners and Probiodrug; alternative approaches to disease progression from TauRx, AC Immune, Prana, Merck/Alectos, Roche/reMYND and NeuroPhage; and those with Phase II data, such as Forum Pharma, Lundbeck, TauRx and Prana. Forum Pharmaceuticals' EVP-6124 exemplifies a new breed of symptomatic therapies that may extend independence, while Acadia Pharmaceuticals' Nuplazid is now in Phase III for Alzheimer's psychosis.

    Other topics covered in NeuroPerspective September:

    • Our commentary on "The Golden Age of Neuroscience" as was recently proposed by an opinion piece in the Wall Street Journal
    • The potential for the geographic and systemic consolidation of resources to reduce innovation and creativity in neurotherapeutics research.
    • The Company Spotlight review covers the neurogenesis specialist Neuronascent.

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