Navigation Links
Alzheimer's Reviewed by NeuroPerspective

CARDIFF, Calif., Sept. 3, 2014 /PRNewswire/ -- NI Research (NIR) has released the September issue of NeuroPerspective, which features a comprehensive review of Alzheimer's therapeutics.

Logo -

"Alzheimer's constitutes the single largest opportunity in the pharma world, but with risk to match, and a daunting legacy of clinical disappointments. It has seen a surprising lack of progress. This is partly due to the sector having allowed theory to drive the science, instead of the other way around. As a result, the path to disease-modifying therapies has seen remarkably little headway made, and symptomatic treatments have taken on greater relative importance," said NeuroPerspective publisher Harry Tracy, PhD.

"It is instructive that the National Institutes of Health (NIH) has set 2025 as their target date for having a disease-modifying drug available for Alzheimer's. This suggests substantial skepticism regarding the disease-modifier crop of 2016-18, since success for any of them would easily translate into a drug becoming available several years before 2025. While NIR's optimistic expectations of 10 or 15 years ago have been turned to ashes, it is difficult to believe that a decade from now, there would not be a treatment that slows the progression of the disease. But since the fingerprint of the pathophysiological root cause has yet to be identified, we are obligated to lower our sights and expectations," he said.
This 51-page issue is the largest and most comprehensive issue of NeuroPerspective ever produced. It includes:

  • An overview of the biology of Alzheimer's as it is currently conceptualized, albeit not yet validated. More attention is being devoted to alternative upstream models, and to downstream access points that may be relevant to multiple neurodegenerative disorders.

  • A review of the many therapeutic strategies that have been employed, and that are currently under development, with a fresh focus upon tau and anti-inflammatory approaches.

  • The companies and programs that are in clinical, preclinical, and discovery stage. Over 230 therapeutic programs are included in this review. The issue includes assessments of continued efforts to find an effective antibody strategy, and the continuing trend towards the omission of Phase IIb testing.
  • The issue also focuses upon variations on the secretase theme from Merck, AstraZeneca, Forum Pharmaceuticals and Novartis; beta-amyloid targeting alternatives from companies like Acumen, Axerion/AstraZeneca, American Life Science Partners and Probiodrug; alternative approaches to disease progression from TauRx, AC Immune, Prana, Merck/Alectos, Roche/reMYND and NeuroPhage; and those with Phase II data, such as Forum Pharma, Lundbeck, TauRx and Prana. Forum Pharmaceuticals' EVP-6124 exemplifies a new breed of symptomatic therapies that may extend independence, while Acadia Pharmaceuticals' Nuplazid is now in Phase III for Alzheimer's psychosis.

Other topics covered in NeuroPerspective September:

  • Our commentary on "The Golden Age of Neuroscience" as was recently proposed by an opinion piece in the Wall Street Journal
  • The potential for the geographic and systemic consolidation of resources to reduce innovation and creativity in neurotherapeutics research.
  • The Company Spotlight review covers the neurogenesis specialist Neuronascent.

About NI Research

NI Research is the leading publisher of independent research on the neurotherapeutics industry, and has developed an unmatched information base regarding both publicly and privately held CNS companies. NeuroPerspective is the authoritative, independent, monthly review of the neurotherapeutics area, providing critical analyses of therapeutics-in-development.

A one-year (1-5 user) subscription to NeuroPerspective is $2,450. The Alzheimer's review issue of NeuroPerspective is being made available as a single-issue purchase for $350.

NI Research has also recently released the 2014-15 edition of NeuroLicensing, which comprehensively reviews current licensing trends in the CNS area, and assesses large and midsize pharma companies in terms of their licensing agendas and performance. In addition, NI Research provides consulting services to the pharma industry.

Further information and online purchasing with immediate download are available at

Contact: NI Research, P.O. Box 1028, Cardiff CA 92007; 760.230.2581


Harry M. Tracy PhD
NI Research Inc.

SOURCE NI Research
Copyright©2014 PR Newswire.
All rights reserved

Related medicine technology :

1. How to Implant the SynCardia Total Artificial Heart Detailed in Peer Reviewed Paper and Matching Video
2. New Peer-Reviewed Study Shows Mixed Results in ACO Medication Readiness To Achieve Quality, Cost Goals
3. Absorption Systems Scientists Publish Peer-reviewed Paper on a Key Drug Transporter
4. U.S. Orthopedic Biomaterials Market & Global Biomaterials Industry Reviewed by Products and Applications in New Research Reports
5. Sigma-Aldrich Launches Novel Search Engine for Peer-Reviewed Literature, Biological Pathway Data and Technology Queries
6. Clinical Results for Orameds Oral Diabetes Treatment Published in Peer Reviewed Journal PLOS ONE
7. E Cigarette Reviewed Offer Exclusive 20% Storewide V2 Cigs Coupon Discount
8. Star Scientific Reports Publication of First Peer-Reviewed Article on the Effects of Anatabine in an Animal Model of Multiple Sclerosis
9. The Future is Remote: Digital Radiology Revolutionizes the Way X-rays are Processed and Reviewed
Post Your Comments:
(Date:12/1/2015)... 2015   MabVax Therapeutics Holdings, Inc . (OTCQB: ... has filed an Investigational New Drug Application (IND) with ... Company,s lead fully human antibody product HuMab 5B1 as ... to initiate the Phase I clinical trial early in ... The planned Phase I trial will evaluate the ...
(Date:12/1/2015)... FRANCISCO , Dec. 1, 2015  InCarda Therapeutics, ... development and commercialization of therapies for cardiovascular conditions via ... a subsidiary business in Australia . ... trial in Australia in the ... leading investigators and medical centers in Adelaide ...
(Date:12/1/2015)... , Dec. 1, 2015  The migration ... to develop shared care plans that help patients ... care plans will be digitally enabled, incorporate care ... needs and desires. They will also allow all ... patient,s health journey is optimal. That is the ...
Breaking Medicine Technology:
(Date:12/1/2015)... ... December 01, 2015 , ... The Multiple System Atrophy Coalition has announced ... Multiple System Atrophy (MSA) research, timed today to coincide with Giving Tuesday 2015, a ... including their ability to work and be productive, to do simple daily activities like ...
(Date:12/1/2015)... ... December 02, 2015 , ... ClinicoEconomics and Outcomes Research ... of treatment for osteoporosis ”. , As corresponding author Dr Ankita Modi says ... with osteoporosis. Based on a large US managed care database, women aged 55 ...
(Date:12/1/2015)... ... December 01, 2015 , ... According to an ... has filed a discrimination claim against the U.S. Department of Health and Human Services, ... Care Act (ACA) plans are breaking the clause in the law prohibiting the denial ...
(Date:12/1/2015)... ... December 01, 2015 , ... Dr. Paul Vitenas, one of the ... named by MedEsthetics magazine as the Best Single Physician Practice in the nation. Dr. ... elite aesthetic physicians honored by the industry publication. , Dr. Vitenas said he ...
(Date:12/1/2015)... York, NY (PRWEB) , ... December 01, 2015 ... ... epidemic in the 1980s we have seen vast improvements in scientific research and ... made significant strides, providing increased hope and relief to those affected by HIV/AIDS. ...
Breaking Medicine News(10 mins):