"One of the biggest problems in AD research is the instability of these toxic protein forms," Kim says. "It's very likely that any existing method of finding them might be misleading; that is, it's like going after a moving target. Detection must be very rapid, specific and quantitative, but there's no such method yet."
That's where his research comes in. "We're trying to develop a biochemical compound -- a specific, rapid and quantitative probe -- that can detect the toxic protein molecule and report its presence quantitatively right away," he says. If such a probe can be developed, it could be used to identify drug-like compounds that can prevent the formation of toxic protein forms, and thus prevent the disease itself. The research is being conducted under a two-year $80,000 New Investigator Research Grant from the Alzheimer's Association (www.alz.org). Kim has filed for a provisional patent, based on preliminary data, for a biochemical probe that would quickly and quantitatively reveal toxic proteins associated with Alzheimer's.
"The goal of our research is a world without Alzheimer's disease," says Kim. "If there's no Alzheimer's in the world, maybe I'd have nothing to do, but it's something I wish. Hopefully, using our probe, maybe a solution is just a few years away."
About Polytechnic Institute of New York University
Polytechnic Institute of New York University (formerly Polytechnic University), an affiliate of New York University, is New York's most comprehensive school of engineering, applied sciences, technology and research, and is rooted in Polytechnic's 155-year tradition of invention, innovation and entrepreneurship -- i-squared-e.
The institution, founded in 1854, is one of the nation's oldest private engineering schools. In addition to its main campus at MetroTech Center in downto
|SOURCE Polytechnic Institute of New York University|
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