Navigation Links
Alzheimer's Research May Lead to Preventing the Debilitating Disease
Date:12/3/2009

NEW YORK, Dec. 3 /PRNewswire/ -- Alzheimer's disease (AD) is one of the most heartbreaking diagnoses a person can receive. This irreversible, progressive brain disease slowly destroys memory and thinking skills and eventually even the ability to carry out the simplest tasks. The most common cause of dementia among older people, AD affects as many as 2.4 million to 4.5 million Americans, according to the National Institute on Aging.

(Logo: http://www.newscom.com/cgi-bin/prnh/20091027/NY99197LOGO )

Jin Ryoun Kim, assistant professor of chemical and biological engineering at Polytechnic Institute of New York University, has been leading a team of researchers including Paramjit Arora, associate professor in NYU's Department of Chemistry; Mary Cowman, professor in NYU-Poly's Department of Chemical and Biological Science, and Jorge Ghiso, NYU School of Medicine associate professor, to make this debilitating disease a thing of the past.

Kim is interested in developing a biochemical probe that would quickly and quantitatively reveal toxic proteins associated with Alzheimer's. Developing an early, reliable diagnostic tool will enable researchers to develop drug-like compounds to prevent the disease.

What triggers Alzheimer's, Kim explains, is protein aggregation, in which a protein molecule sticks to neighboring identical molecules, ending up as a toxic form that interferes with normal brain functioning. While all humans have these protein molecules, young people's bodies are able to prevent accumulation of toxic forms of the protein. But as people age, they become more vulnerable to their effects.

Toxic molecules generated during the aggregation process have been directly linked to the onset of Alzheimer's. Unfortunately, the toxic molecule is difficult to detect: It's very unstable, and can change shape, structure or biological effect easily and rapidly.

"One of the biggest problems in AD research is the instability of these toxic protein forms," Kim says. "It's very likely that any existing method of finding them might be misleading; that is, it's like going after a moving target. Detection must be very rapid, specific and quantitative, but there's no such method yet."

That's where his research comes in. "We're trying to develop a biochemical compound -- a specific, rapid and quantitative probe -- that can detect the toxic protein molecule and report its presence quantitatively right away," he says. If such a probe can be developed, it could be used to identify drug-like compounds that can prevent the formation of toxic protein forms, and thus prevent the disease itself. The research is being conducted under a two-year $80,000 New Investigator Research Grant from the Alzheimer's Association (www.alz.org). Kim has filed for a provisional patent, based on preliminary data, for a biochemical probe that would quickly and quantitatively reveal toxic proteins associated with Alzheimer's.

"The goal of our research is a world without Alzheimer's disease," says Kim. "If there's no Alzheimer's in the world, maybe I'd have nothing to do, but it's something I wish. Hopefully, using our probe, maybe a solution is just a few years away."

About Polytechnic Institute of New York University

Polytechnic Institute of New York University (formerly Polytechnic University), an affiliate of New York University, is New York's most comprehensive school of engineering, applied sciences, technology and research, and is rooted in Polytechnic's 155-year tradition of invention, innovation and entrepreneurship -- i-squared-e.

The institution, founded in 1854, is one of the nation's oldest private engineering schools. In addition to its main campus at MetroTech Center in downtown Brooklyn, it offers programs at sites throughout the region and around the globe. NYU-Poly has centers in Long Island, Manhattan and Westchester County; globally, it has programs in Israel, China and will be an integral part of NYU's campus in Abu Dhabi opening in autumn 2010.

For more information, visit www.poly.edu.

SOURCE Polytechnic Institute of New York University


'/>"/>
SOURCE Polytechnic Institute of New York University
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
2. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
3. Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate
4. Researchers at Cleveland Clinic Identify Site of Dysfunction in HDL, Carrier of Good Cholesterol
5. Video: New Research Discovers Independent Brain Networks Control Human Walking
6. Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute Hearing Loss
7. Cleveland Clinic Researchers Identify Mechanism Behind Platelet Function and Potentially Fatal Blood Clot Formation
8. HistoRx and Radiation Therapy Oncology Group Initiate Brain Tumor Biomarker Research Partnership
9. Diabetes Research Institute Invention Promotes Growth of Stem Cells into Insulin-Producing Cells
10. Researchers Identify Virus Possibly Responsible for Declining Honeybee Population Using 454 Sequencing Technology from Roche
11. Peregrine Researchers Report Data Showing Bavituximabs Potential to Shrink Human Prostate Tumors in Model of Relapsed Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... YORK , December 2, 2016 ... Braces & Support) is Expected to Gain a Significant Market ... to Orthopedic Ailments  ... , According to ... Study on Medical Implants Sterile Packaging: Clamshell Product Type Segment ...
(Date:12/2/2016)... On Thursday, the NASDAQ Composite and ... the Dow Jones Industrial Average managed to stay in green. ... which prompted Stock-callers this morning to look at the performances ... NUVA ), Smith & Nephew PLC (NYSE: SNN ... Cesca Therapeutics Inc. (NASDAQ: KOOL ). You can ...
(Date:12/2/2016)... -- The concept of rare diseases and the idea that ... has been taking shape in Europe ... initiatives related to orphan medicinal products have been emerging at ... states individually. Many member states in the EU have led ... medicinal products, the result of which took the shape of ...
Breaking Medicine Technology:
(Date:12/2/2016)... ... December 02, 2016 , ... The annual time frame to change Medicare health ... is ending December 7th. Currently-enrolled Medicare beneficiaries who are looking to switch from their ... D) need to make changes during this period order for their new policy to ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... More than ... and while 84 percent of parents report speaking with their child about sex related ... sexually transmitted diseases. , Mediaplanet is proud to announce the launch of its second ...
(Date:12/2/2016)... ... December 02, 2016 , ... Sourced from the Isbre Springs beneath the 5,000 ... unmatched natural purity of just 6 ppm TDS (Total Dissolved Solids) in addition to ... been available in several ShopRite and FoodTown stores in NJ and received rave comments ...
(Date:12/2/2016)... Miami, FL (PRWEB) , ... December 02, 2016 ... ... over 5,100 hot meals to needy individuals and families from eight different sites ... Florida on Thanksgiving Day. Over 1,000 volunteers worked very hard on Thanksgiving morning ...
(Date:11/30/2016)... , ... November 30, 2016 , ... ... they now offer a comprehensive in-house dental plan for all patients. Understanding that ... a plan that gives patients a number of perks, including discounts on many ...
Breaking Medicine News(10 mins):