Navigation Links
Alzheimer's Drug Discovery Foundation Supports Madera Biosciences to Advance Small Molecule Drugs that Upregulate apoE
Date:6/12/2013

NEW YORK, June 12, 2013 /PRNewswire-USNewswire/ -- The Alzheimer's Drug Discovery Foundation (ADDF) announced that it has awarded follow-on funding of $298,500 to Madera Biosciences, Inc. to further develop its small molecule drugs designed to clear accumulated beta-amyloid from the brain and thus halt or reverse the progression of Alzheimer's disease.

Madera has identified a series of proprietary, small molecule compounds that increase the expression of apolipoprotein E (apoE), which has been shown to mediate beta-amyloid clearance from the brain and prevent its accumulation into the plaques that are characteristic of Alzheimer's disease. ApoE is a lipid-binding protein that circulates in the blood and the brain.  Increasing the release of apoE from brain cells has been shown to decrease beta-amyloid plaques and improve cognitive function in animal models.

Madera's novel, drug-like compounds facilitate the release of apoE, may aid the beta-amyloid clearance process and are hypothesized to improve symptoms, slow the progression of Alzheimer's disease and potentially reverse the course of the disease. Madera's lead compound has both excellent exposure suggesting once-a-day dosing and brain penetrance, enabling the drug to enter the brain where it increases apoE production.  The ADDF's funding will allow Madera to advance these compounds for proof-of-concept testing in animal models of Alzheimer's disease.

"We are excited to continue our work with the ADDF to advance these promising orally-available compounds. The ADDF's support is critical to achieve our goal of providing Alzheimer's patients a therapy that changes the course of the disease," said Rick Jack, Ph.D., Chief Executive Officer for Madera. "These funds will allow us to gain a better in vivo understanding of how our compounds affect the pathologies caused by beta-amyloid deposition."

"Madera's unique approach to enhance the secretion apoE holds great promise as a treatment for Alzheimer's disease," said Howard Fillit, MD, Executive Director and Chief Science Officer for the ADDF. "Since apoE is the leading known risk factor for Alzheimer's disease (after aging), developing therapeutics based on our knowledge of apoE biology is a critical challenge in our field."

There are estimated to be more than 5 million patients in the United States and more than 35 million individuals worldwide suffering from Alzheimer's disease. The disease is believed to have an annual impact of $172 billion on health care in the United States and is projected to increase rapidly in the near future.

About the Alzheimer's Drug Discovery Foundation (www.AlzDiscovery.org)
The mission of the Alzheimer's Drug Discovery Foundation (ADDF) is to accelerate the discovery of drugs to prevent, treat and cure Alzheimer's disease, related dementias and cognitive aging. The ADDF has granted more than $60 million to fund almost 400 Alzheimer's drug discovery programs in academic centers and biotechnology companies in 18 countries.

About Madera Biosciences (www.maderabiosciences.com)
Madera Biosciences is a biotechnology drug discovery company focusing on disease-modifying drugs for Alzheimer's disease. The company was founded in 2008 by Edwin Iwanowicz, Ph.D. and is headquartered in San Diego, CA.


'/>"/>
SOURCE Alzheimer's Drug Discovery Foundation
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Discovery Labs Presents Final Assessment in a Series of Pharmacoeconomic Analyses that Explore Impact of Reintubation on Healthcare Costs
2. Quantum Materials Tetrapod Quantum Dots Break Kashas Rule: Enhanced Performance Enables Commercialization of Novel Discovery
3. Novira Therapeutics Expands Management Team with Appointment of Klaus Klumpp, Ph.D., the Former Global Head of Roches Virology Discovery Initiatives, as Vice President Discovery Research
4. Second Genome Announces Agreement with Janssen on Microbiome Drug Discovery in Ulcerative Colitis
5. Cardinal Health Selects Datameer for Healthcare Data Discovery
6. Discovery Labs Reports First Quarter 2013 Financial Results
7. Ambrx Initiates Collaboration with Bristol-Myers Squibb for Discovery, Development of Next-Generation Antibody Drug Conjugates
8. Afraxis, Inc. and Servier Announce a Collaboration on ESP Platform for Drug Discovery in Central Nervous System Disorders
9. Kymab Announces Kymouse Antibody Discovery Agreement With Novo Nordisk
10. MetaStat Appoints David Epstein, Ph.D. as Advisor to Lead Drug Discovery
11. Family Tree DNAs Genomics Research Center Facilitates Discovery of Extremely Ancient Root to the Human Y Chromosome Phylogenetic Tree
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... 2017 Today Stock-Callers.com have issued research ... Neovasc Inc. (NASDAQ: NVCN), Hologic Inc. (NASDAQ: HOLX), Edwards Lifesciences ... SSH ). These companies are part of the Healthcare sector, ... March 23 rd , 2017, with the NYSE Health Care ... care companies in the S&P 500 were down about 0.4% ...
(Date:3/24/2017)... , March 24, 2017  GenomeDx Biosciences today announced ... Database) and Decipher® Prostate Cancer Classifier tests will be ... of Urology (EAU) Congress held March 24 to 28, ... Annual EAU Congress is Europe,s ... research in the urological field. The abstract ...
(Date:3/24/2017)...  HealthMine surveys with 9,250 insured consumers fielded from ... members want help from their plans in five key ... health, 2) help closing gaps in care, 3) better ... 5) relevant, real-time guidance. Meeting these needs is essential ... A Reason to Stay Engaged in ...
Breaking Medicine Technology:
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... to the military at the same time by providing Prehospital Trauma Life Support ... PHTLS is the world’s premier prehospital trauma education developed in cooperation with the ...
(Date:3/24/2017)... ... , ... Digital Scientists, a software innovation lab specializing in web design and ... South Carolina location. The lab has set up shop at the renowned NEXT ... South Carolina clients for years from our office here in Atlanta,” explains Digital Scientists’ ...
(Date:3/24/2017)... San Antonio, TX (PRWEB) , ... March 24, 2017 , ... ... a new clinic which can be found at 9618 Huebner Road. The clinic is ... Thobaben, PT, OCS, Clinic Director, and Dr. Ali Higgins, PT, will provide care from ...
(Date:3/24/2017)... ... March 24, 2017 , ... Shamanic healer and teacher Anahata ... and Spiritual Awakening, proudly presents her Sacred Peru retreat with world famous ... spiritual journey during the Summer Solstice will also be her final international retreat, ...
(Date:3/24/2017)... , ... March 24, 2017 , ... ... announce that they are now offering treatments for sleep apnea and TMJ at ... offices. Sleep apnea , specifically the obstructive type, is increasingly being treated ...
Breaking Medicine News(10 mins):