Navigation Links
Alpharma Presents Data Addressing Abuse Liability Features, Safety and Efficacy on ALO-01 (EMBEDA(TM)) (morphine sulfate extended-release with sequestered naltrexone hydrochloride) at the American Pain Society Annual Scientific Session
Date:5/8/2008

y patient diaries during the treatment periods using the Brief Pain Inventory (BPI); and pre- and post-treatment scores using the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index of pain, stiffness and function. Plasma levels were evaluated for morphine sulfate and naltrexone pre-dose and at specified intervals up to 12 hours post-dose on days seven and 14 of the treatment periods, and at the end of the study. Follow-up calls with patients a further seven days after the end of the study were conducted to assess the occurrence of any adverse events.

During treatment, ALO-01 was similar to extended-release morphine sulfate for mean pain intensity (2.3 to 2.4 at Day 14) and BPI (average 2.1 to 2.2). WOMAC scores were also comparable with composite indices of 24.5 for ALO-01 and 26.6 for extended-release morphine sulfate. Plasma concentrations of morphine were similar over time, and naltrexone levels at the end of each treatment period below a quantifiable limit for most patients (82.1 percent). In patients with detectable levels of naltrexone, there was no impact on pain scores. Adverse events were mostly mild to moderate, and included constipation (15.5 percent and 12.7 percent), nausea and somnolence (both 9.9 percent and 8.5 percent) for ALO-01 and extended-release morphine sulfate, respectively.

Statements made in this release include forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements, including those relating to future financial expectations, involve certain risks and uncertainties that could cause actual results to differ materially from those in the forward-looking statements. Information on other important potential risks and uncertainties not discussed herein may be found in the Company's filings with the Securities and Exchange Commission including its Form 10-K for the year ended December 31, 2007.

About Alpharma

Alpharma Inc. (NYSE: '/>"/>

SOURCE Alpharma Pharmaceuticals
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Dr. Calvin Grant Presents Results from Xibrom(TM) Combination Therapy with Lucentis(R) at the 2008 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
2. Pharmasset Presents Results of 4-Week Combination Study of R7128 for the Treatment of Chronic Hepatitis C
3. Idenix Pharmaceuticals Presents Positive Preclinical Data on HCV Programs at The Annual Meeting of The European Association for the Study of the Liver (EASL)
4. ACORN Presents Findings of Collaborative Metastatic Colorectal Cancer Research
5. Anadys Pharmaceuticals Presents Data on ANA598, a Non-Nucleoside Inhibitor of the HCV Polymerase, at the 21st International Conference on Antiviral Research
6. Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR
7. Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference
8. EntreMed Presents MKC-1 and ENMD-1198 Preclinical Data at AACR Annual Meeting
9. Ardea Biosciences Presents Data Demonstrating Favorable Pharmacokinetics and Efficacy for Mitogen-Activated ERK Kinase (MEK) Inhibitors
10. Halozyme Therapeutics Presents Pre-Clinical Studies of Systemic Delivery of Pegylated rHuPH20 Enyzme in Prostate Cancer Models at American Association for Cancer Research Conference
11. Micromet Presents Safety and Efficacy Data from Primate Studies With Two New BiTE Antibodies Developed for Treatment of Leukaemia and Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... PLEASANTON, Calif. , Nov. 26, 2014  Thoratec ... in device-based mechanical circulatory support therapies to save, support ... participating in two upcoming investor conferences. On ... 26 th Annual Piper Jaffray Healthcare Conference.  ... will provide an update on the company beginning at ...
(Date:11/26/2014)... -- Perrigo Company plc ("Perrigo") (NYSE: PRGO ; ... Products®," today announced the closing of Perrigo,s previously announced ... ordinary shares at a public offering price of $152.00 ... to purchase up to an additional 888,157 ordinary shares ... as representatives of the several underwriters. ...
(Date:11/26/2014)... , Nov. 26, 2014 Lexicon Pharmaceuticals, ... the completion of previously announced concurrent financing transactions ... fees and estimated offering expenses, Lexicon anticipates net ...  The transactions consisted of: , a ... pursuant to a registration statement that has been ...
Breaking Medicine Technology:Thoratec Announces Presentations At Investor Conferences For December 2014 2Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 2Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 3Perrigo Company plc Announces The Closing Of Its Registered Public Offering Of Ordinary Shares 4Lexicon Announces Completion Of $280 Million In Financing Transactions 2Lexicon Announces Completion Of $280 Million In Financing Transactions 3
... announced that it has filed a lawsuit in the Netherlands ... Labem, Czech Republic, where Dr. Cervinka is head of the ... conducted at the Masaryk Hospital, in which Dr. Cervinka was ... stent with a bare metal stent for treatment of a ...
... CSL Behring today announced the development ... absorption, distribution, metabolism, and elimination of subcutaneous (SC) immunoglobulin ... high degree of accuracy and precision. The new PK ... by which SC IgG is transported after it is ...
Cached Medicine Technology:OrbusNeich Files Lawsuit Against Dr. Pavel Cervinka for Defamation 2OrbusNeich Files Lawsuit Against Dr. Pavel Cervinka for Defamation 3New Model Provides Insights Into Intravenous and Subcutaneous Immunoglobulin Pharmacokinetics in Patients With Primary Immunodeficiencies 2New Model Provides Insights Into Intravenous and Subcutaneous Immunoglobulin Pharmacokinetics in Patients With Primary Immunodeficiencies 3New Model Provides Insights Into Intravenous and Subcutaneous Immunoglobulin Pharmacokinetics in Patients With Primary Immunodeficiencies 4New Model Provides Insights Into Intravenous and Subcutaneous Immunoglobulin Pharmacokinetics in Patients With Primary Immunodeficiencies 5New Model Provides Insights Into Intravenous and Subcutaneous Immunoglobulin Pharmacokinetics in Patients With Primary Immunodeficiencies 6
(Date:11/28/2014)... November 29, 2014 TideStore.com , has ... new dresses, shoes and other fashion items recently. Its 2014 ... site. , The special offer is valid during Nov. ... tops, stylish women outwears, charming dresses, shining prom shoes, essential ... leading online store offering many trendy clothes and fashion accessories. ...
(Date:11/28/2014)... 2014 The report “Poxvirus Infections ... the therapeutic development for Poxvirus Infections, complete with ... drug target, mechanism of action (MoA), route of ... updates, and featured news and press releases. It ... development for Poxvirus Infections and special features on ...
(Date:11/28/2014)... sells cheap tall cocktail dresses worldwide and ... there is a new collection of tall cocktail dresses ... at very low prices. It is really worthy to ... by UWDress.com , UWDress.com is one of the most ... has the power to ensure customer satisfaction. Now, the ...
(Date:11/28/2014)... 29, 2014 Angelweddingdress.com, a world-famous ... collection of Blue Color Styles of ... up to 80% off and free shipping on ... discounted blue bridesmaid dresses for less at the ... Angelweddingdress.com is famous as a reliable dress supplier ...
(Date:11/28/2014)... New York, NY (PRWEB) November 28, 2014 ... ground-breaking physical therapy techniques such as Dynamic Neuromuscular ... therapy, and gait/motion analysis. After moving to upgraded ... sports and running clinic. Now, owner Dr. Lev ... movement performance and injury prevention lab in the ...
Breaking Medicine News(10 mins):Health News:2014 Special Monday Sales from TideStore.com 2Health News:Poxvirus Infections and Vestibular Diseases Pipeline Market Drugs and Companies Review H2 2014 2Health News:Poxvirus Infections and Vestibular Diseases Pipeline Market Drugs and Companies Review H2 2014 3Health News:Poxvirus Infections and Vestibular Diseases Pipeline Market Drugs and Companies Review H2 2014 4Health News:Graceful Tall Cocktail Dresses With New Features Just Added To UWDress.com 2Health News:Blue Color Styles of Bridesmaid Dresses from AngelWeddingDress.com are Available Now With Big Discounts 2Health News:New York Dynamic Neuromuscular Rehabilitation Opens Nation's Most Advanced Movement Performance and Injury Prevention Lab 2Health News:New York Dynamic Neuromuscular Rehabilitation Opens Nation's Most Advanced Movement Performance and Injury Prevention Lab 3
... ANN ARBOR, Mich. -- Only about one in five young ... the 2009-2010 swine flu epidemic, according to a University of ... X. But about 65 percent were at least moderately ... were following the issue very or moderately closely. Using ...
... Marriage offers few well-being advantages compared to living together, a ... benefits of marriage diminish over time, while unmarried couples who ... data from 2,737 single men and women who took part ... those people, 896 married or moved in with a partner ...
... Reporter , MONDAY, Jan. 23 (HealthDay News) -- Shedding some light ... finds that parts of your immune system ramp up when you ... this effect of stress may make you sick, but the activated ... body -- have been linked to conditions such as diabetes and ...
... MONDAY, Jan. 23 (HealthDay News) -- Although many people believe ... the opposite may be true with traumatic brain injuries. ... injury in children as young as 2 years, and found ... for some time. However, the researchers also found that recovery ...
... more than 40 years, scientists and physicians have thought eating ... disease of the large intestine in which pouches develop in ... people reveals the opposite may be true. The study, ... Chapel Hill School of Medicine , found that consuming a ...
... A new study published online today in the ... finds hospitals participating in a regional collaborative of the ... (ACS NSQIP), achieved substantial improvements in surgical outcomes, such ... surgical site infections. The collaborative also saved $2,197,543 per ...
Cached Medicine News:Health News:Generation X: How young adults deal with influenza 2Health News:Living Together May Be Mentally Healthier Than Marriage: Study 2Health News:Study Shows How Stress Triggers Immune System 2Health News:Study Shows How Stress Triggers Immune System 3Health News:Severe Brain Injury When Young May Have Long-Term Effects 2Health News:Severe Brain Injury When Young May Have Long-Term Effects 3Health News:Severe Brain Injury When Young May Have Long-Term Effects 4Health News:Diets high in fiber won't protect against diverticulosis 2Health News:Regional surgical quality collaborative significantly improves surgical outcomes and reduces cost 2Health News:Regional surgical quality collaborative significantly improves surgical outcomes and reduces cost 3
... The Series I Instrument program offers state-of-the-art ... profile, while maintaining strength and durability. Low ... in tight joint spaces. Series I instruments ... tip style, size and angle required for ...
... facilitates fast and effective resection of meniscal ... meniscal rim. The flat, crescent-shaped tip has ... the tightest joint spaces. Made in the ... of engineering experience in arthroscopy hand instrument ...
... facilitates fast and effective resection of meniscal ... meniscal rim. The flat, crescent-shaped tip has ... the tightest joint spaces. Made in the ... of engineering experience in arthroscopy hand instrument ...
... The WideBiter Punch series facilitates fast and ... a smooth, anatomically shaped meniscal rim. The ... profile to access even the tightest joint ... California, Inc., 20 years of engineering experience ...
Medicine Products: