Navigation Links
Alpharma Presents Data Addressing Abuse Liability Features, Safety and Efficacy on ALO-01 (EMBEDA(TM)) (morphine sulfate extended-release with sequestered naltrexone hydrochloride) at the American Pain Society Annual Scientific Session
Date:5/8/2008

potential prescription opioid abuse, patients and physicians may be reluctant to initiate opioid therapy for pain relief(4B) and, therefore, there is a need for products that deliver effective pain relief while minimizing the potential for misuse, abuse and diversion.(3B,7)

Study Findings

The first study, a Phase I randomized, double-blind, 4-way crossover trial, compared the effects of ALO-01 (2x 60 mg capsules), when taken whole as intended, against ALO-01 crushed and taken orally, immediate-release morphine sulfate solution (120 mg) and placebo capsules. Participants were healthy adults (N=32) who were not currently physically opioid-dependent but had used opioids to attain non-medical effects on at least 10 occasions during the past year and at least once in the 12 weeks before the study. Study participants sequentially received the four treatments, administered in a randomized, double-blinded fashion, with each treatment separated by a 14-21 day washout period.

Following each treatment, participants assessed drug liking, feeling high, good and bad effects using a visual analog scale (VAS) and completed questionnaires designed to rate abuse potential, stimulation/euphoria and subjective drug value. In addition, plasma levels of both morphine and naltrexone were measured pre-dose and at specified intervals up to 24 hours after each treatment.

Scores for drug liking, feeling high, and good effects were similar for ALO-01 crushed compared to ALO-01 whole (68.1 to 67.6, 55.0 to 60.6 and 52.1 to 59.4, respectively). These scores were significantly higher for morphine sulfate solution (89.5, 90.4 and 89.7, respectively, p less than or equal to 0.002), and peaked sharply around 1.5 hours after exposure, consistent with the time of maximum plasma levels for immediate-release morphine. Scores for stimulation/euphoria, abuse potential and subjective drug value were also similar for ALO-01 crushed and whole, but were significantly higher for mo
'/>"/>

SOURCE Alpharma Pharmaceuticals
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Dr. Calvin Grant Presents Results from Xibrom(TM) Combination Therapy with Lucentis(R) at the 2008 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
2. Pharmasset Presents Results of 4-Week Combination Study of R7128 for the Treatment of Chronic Hepatitis C
3. Idenix Pharmaceuticals Presents Positive Preclinical Data on HCV Programs at The Annual Meeting of The European Association for the Study of the Liver (EASL)
4. ACORN Presents Findings of Collaborative Metastatic Colorectal Cancer Research
5. Anadys Pharmaceuticals Presents Data on ANA598, a Non-Nucleoside Inhibitor of the HCV Polymerase, at the 21st International Conference on Antiviral Research
6. Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR
7. Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference
8. EntreMed Presents MKC-1 and ENMD-1198 Preclinical Data at AACR Annual Meeting
9. Ardea Biosciences Presents Data Demonstrating Favorable Pharmacokinetics and Efficacy for Mitogen-Activated ERK Kinase (MEK) Inhibitors
10. Halozyme Therapeutics Presents Pre-Clinical Studies of Systemic Delivery of Pegylated rHuPH20 Enyzme in Prostate Cancer Models at American Association for Cancer Research Conference
11. Micromet Presents Safety and Efficacy Data from Primate Studies With Two New BiTE Antibodies Developed for Treatment of Leukaemia and Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... May 22, 2015 According to ... by Product (Consumables, Instruments, Services), by Test Type (Indirect, ... Flow Cytometry), by End Users - Global Forecast to ... is expected to reach $736.85 Million by 2020 from ... 10.25%. Browse 71 market data Tables ...
(Date:5/22/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/28m7nx/guide_to_prepare ) has announced ... Application Dossiers for Oversea Medical device registration and ... to their offering. The Chinese medical ... the most growth potentiality, which is attracting more ... to penetrate such market. It is estimated that ...
(Date:5/22/2015)... InspireMD, Inc. (NYSE MKT: NSPR) ("InspireMD" or the "Company"), ... that its CGuard TM Embolic Prevention System reported positive ... Musialek , at the EuroPCR conference on May ... PARADIGM, an investigator-initiated P rospective evaluation of ... revascularization I n symptomatic and increased-risk asymptomatic carotid artery ...
Breaking Medicine Technology:Oxidative Stress Assays Market Worth $736.85 Million by 2020 2Oxidative Stress Assays Market Worth $736.85 Million by 2020 3Oxidative Stress Assays Market Worth $736.85 Million by 2020 4China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 2China Guide to Prepare Application Dossiers for Oversea Medical Device Registration and Recordation 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 2InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 3InspireMD's CGuardTM Highlighted at Clinical Presentation at EuroPCR 2015 Conference 4
(Date:5/22/2015)... Gateway Building Concepts is experienced with ... the company specialize in include decks, additions, kitchen remodeling, ... and much more. , The redesigned logo is ... the company. It includes two geometrical lines that represent ... out to be used with many things associated with ...
(Date:5/22/2015)... (PRWEB) May 22, 2015 Medivo, Inc., a ... “Positivity Rates and Genotype Results in ‘Baby Boomers’ Screened for ... a Nationwide Lab Test Database” at Digestive Disease Week, May ... Clinical Affairs and Analytics team members Carol Smyth, MB; Jason ... Andrea Parker, MSI, along with Nancy Reau, MD from the ...
(Date:5/22/2015)... sweetFrog Enterprises, LLC. is pleased to announce the opening ... the 16th sweetFrog store located in the Lone Star State. ... the Inc. 500 list of fastest growing companies in 2014. ... Texas for 20 years and love the natural beauty and ... nearby Palestine, sweetFrog locations. “We are really excited about giving ...
(Date:5/22/2015)... Alexandria, VA (PRWEB) May 22, 2015 ... be presented at the American Society of Clinical ... May, demonstrated improved survival rates for those patients ... standard chemotherapy regimen of pemetrexed/cisplatin. Bevacizumab (Avastin® Genentech, ... vessel growth), and it is already routinely used ...
(Date:5/22/2015)... Wimbledon Health Partners, the leading on-site ... and NCV testing , is proud to announce ... American National athlete, to the Wimbledon Athletics division. ... level of testing and information it provides to be ... trainers, this way they can focus on the task ...
Breaking Medicine News(10 mins):Health News:Medivo Study Finds HCV Positivity Rates are 250% Higher Among Baby Boomers 2Health News:sweetFrog Opens New Location in Jacksonville, Texas 2Health News:Mesothelioma Research Organization Excited About Imminent Improvement to Standard of Care 2Health News:Wimbledon Athletics Recruits Team USA Athlete 2Health News:Wimbledon Athletics Recruits Team USA Athlete 3
... school building will be reopened after a medical report found no ... staffs working on the 16th and 17th floors of the building. ... cluster was detected in the staffs working in the top two ... found to have malignant tumors, while six had benign tumors. ...
... new cases of skin cancer will be diagnosed in ... deadly //condition is extremely treatable, averaging a cure rate ... involve treating or removing both cancerous and healthy skin, ... the cancerous cells. ,Speaking today at ACADEMY ’06, ...
... things on her hormones: unpredictable emotions, weight gain and ... , These changes occur as the levels of hormones ... abnormalities in hormone levels occur. A dermatologist can provide ... during a woman’s lifetime. ,Speaking today at ACADEMY ...
... for a while due to its eradication, yet people could ... not been vaccinated says a recent report.// ... had spread after an unvaccinated teenager contracted the virus and ... gathering. This spurred a large outbreak in USA, which also ...
... CMV infects about 40,000 children before birth and about ... the virus – almost one an hour.// , ... disability, a lack of coordination, and seizures. According to ... as common a cause of serious disability as Down ...
... held every two years in various cities around the world, ... of August. // ,The conference, ‘AIDS 2006’, which is ... 20,000 participants from across 120 countries. This conference, whose theme ... for the world’s top medical authorities and AIDS experts, will ...
Cached Medicine News:Health News:Emerging Therapies for Skin Cancer Treatment 2Health News:Emerging Therapies for Skin Cancer Treatment 3Health News:Emerging Therapies for Skin Cancer Treatment 4Health News:A Balancing Act: Hormones and the Skin 2Health News:A Balancing Act: Hormones and the Skin 3Health News:A Balancing Act: Hormones and the Skin 4Health News:Creation of Cytomegalovirus Vaccine by an Innovative Method 2Health News:XVI International AIDS Conference To Be Held In Toronto In August 2
Bipolar forceps...
... in vitro Nucleic Acid Hybridization ... Microplate Chemiluminescence for the Qualitative ... Types 6,11,16,18,31,33,35,39,42,43,44,45,51,52,56,58,59 and 68 and ... High-Risk Groups in Cervical Specimens: ...
... superb radiation protection-0.62mm (+/- .05)Pb lead glass ... to their level of protection, they are ... smoothly on your bridge while hugging your ... wear corrective lenses, you can order Leaded ...
... first time in the world, there is a ... to diagnose VVC in female patients. CanDia5® is ... detect the Candida antigens almost instantaneously (within 5 ... blood. There is no similar POC product for ...
Medicine Products: