Navigation Links
Alpharma Presents Data Addressing Abuse Liability Features, Safety and Efficacy on ALO-01 (EMBEDA(TM)) (morphine sulfate extended-release with sequestered naltrexone hydrochloride) at the American Pain Society Annual Scientific Session
Date:5/8/2008

potential prescription opioid abuse, patients and physicians may be reluctant to initiate opioid therapy for pain relief(4B) and, therefore, there is a need for products that deliver effective pain relief while minimizing the potential for misuse, abuse and diversion.(3B,7)

Study Findings

The first study, a Phase I randomized, double-blind, 4-way crossover trial, compared the effects of ALO-01 (2x 60 mg capsules), when taken whole as intended, against ALO-01 crushed and taken orally, immediate-release morphine sulfate solution (120 mg) and placebo capsules. Participants were healthy adults (N=32) who were not currently physically opioid-dependent but had used opioids to attain non-medical effects on at least 10 occasions during the past year and at least once in the 12 weeks before the study. Study participants sequentially received the four treatments, administered in a randomized, double-blinded fashion, with each treatment separated by a 14-21 day washout period.

Following each treatment, participants assessed drug liking, feeling high, good and bad effects using a visual analog scale (VAS) and completed questionnaires designed to rate abuse potential, stimulation/euphoria and subjective drug value. In addition, plasma levels of both morphine and naltrexone were measured pre-dose and at specified intervals up to 24 hours after each treatment.

Scores for drug liking, feeling high, and good effects were similar for ALO-01 crushed compared to ALO-01 whole (68.1 to 67.6, 55.0 to 60.6 and 52.1 to 59.4, respectively). These scores were significantly higher for morphine sulfate solution (89.5, 90.4 and 89.7, respectively, p less than or equal to 0.002), and peaked sharply around 1.5 hours after exposure, consistent with the time of maximum plasma levels for immediate-release morphine. Scores for stimulation/euphoria, abuse potential and subjective drug value were also similar for ALO-01 crushed and whole, but were significantly higher for mo
'/>"/>

SOURCE Alpharma Pharmaceuticals
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Dr. Calvin Grant Presents Results from Xibrom(TM) Combination Therapy with Lucentis(R) at the 2008 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
2. Pharmasset Presents Results of 4-Week Combination Study of R7128 for the Treatment of Chronic Hepatitis C
3. Idenix Pharmaceuticals Presents Positive Preclinical Data on HCV Programs at The Annual Meeting of The European Association for the Study of the Liver (EASL)
4. ACORN Presents Findings of Collaborative Metastatic Colorectal Cancer Research
5. Anadys Pharmaceuticals Presents Data on ANA598, a Non-Nucleoside Inhibitor of the HCV Polymerase, at the 21st International Conference on Antiviral Research
6. Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR
7. Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference
8. EntreMed Presents MKC-1 and ENMD-1198 Preclinical Data at AACR Annual Meeting
9. Ardea Biosciences Presents Data Demonstrating Favorable Pharmacokinetics and Efficacy for Mitogen-Activated ERK Kinase (MEK) Inhibitors
10. Halozyme Therapeutics Presents Pre-Clinical Studies of Systemic Delivery of Pegylated rHuPH20 Enyzme in Prostate Cancer Models at American Association for Cancer Research Conference
11. Micromet Presents Safety and Efficacy Data from Primate Studies With Two New BiTE Antibodies Developed for Treatment of Leukaemia and Melanoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... , July 30, 2015  ResMed (NYSE: ... signed a definitive agreement to acquire Curative ... ventilation and sleep-disordered breathing medical devices and ... market reputation in China, combined with ResMed,s global leadership in sleep and ... China suffering from ...
(Date:7/30/2015)...  Tandem Diabetes Care®, Inc. (NASDAQ: TNDM ... the t:slim® and t:flex™ Insulin Pumps, today announced ... with Dexcom, Inc. to allow the integration of ... G5 and G6 continuous glucose monitoring ("CGM") systems. ... with Dexcom,s future CGM systems is an important ...
(Date:7/30/2015)... 2015  Unichem Pharmaceuticals ( USA ), ... tablets 25 mg 1000-count bottle to the consumer level. ... due to the identification of a Clopidogrel tablet found ... The risk associated with mistakenly taking a Clopidogrel tablet ... of experiencing Clopidogrel,s side effects which include bleeding and/or ...
Breaking Medicine Technology:ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 2ResMed Invests in High-Growth Chinese Sleep and Respiratory Care Market with Curative Medical 3Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 3Unichem Pharmaceuticals (USA), Inc. Issues a Voluntary Nationwide Recall of Hydrochlorothiazide Tablets Due to the Potential Presence of Foreign Tablets 2
... the Company) (NASDAQ: HOLX ), a leading ... imaging systems and surgical products dedicated to serving the ... (Conceptus) request for an injunction barring future sales of ... and that no royalty will be due to Conceptus ...
... BASIS Science, Inc. ( www.mybasis.com ) the creators of the ... B1 band, will be demoing at the 2012 International CES ... for the first time. The dashboard has been designed as ... health and wellness. "We have designed the Basis ...
Cached Medicine Technology:Hologic Announces Denial of Conceptus' Request for Injunction in Patent Infringement Suit 2Hologic Announces Denial of Conceptus' Request for Injunction in Patent Infringement Suit 3BASIS Science to Demo Basis Band at 2012 International CES; Reveals Design of Web Dashboard 2
(Date:7/30/2015)... ... 30, 2015 , ... In a meaningful ritual intended to symbolize a final ... Center have created an addiction graveyard. Sharing this with the public comes at a ... Rocky Hudson . Hudson (1945-2015) fell in love with the desert when he moved ...
(Date:7/30/2015)... Diego, CA (PRWEB) , ... July 30, 2015 ... ... has been consistently growing into one of the largest, family-owned low cost service ... across residential and commercial applications, as well as growing their company to meet ...
(Date:7/30/2015)... ... July 30, 2015 , ... The need for accessibility ... effort to provide comfort to patients as well as visiting friends and family during ... phone charging stations. , The stations - powered by ChargeItSpot , a Philadelphia-based ...
(Date:7/30/2015)... ... July 30, 2015 , ... The Mesothelioma Applied Research Foundation ... Registry Act of 2015’. The bill was introduced in Congress yesterday by Representatives ... McCollum (D-MN), Joe Kennedy (D-MA), and Leonard Lance (R-NJ). The purpose of the ...
(Date:7/30/2015)... ... July 30, 2015 , ... On July 23rd Clay ... taxpayer money to fund the state’s large prison system, which has amassed largely enough ... rates of incarceration. In light of President Obama’s recent reduction of non violent drug ...
Breaking Medicine News(10 mins):Health News:Serenity Palms Honors Rocky Hudson, an Advocate of AA and a Beloved Resident of Palm Springs 2Health News:Serenity Palms Honors Rocky Hudson, an Advocate of AA and a Beloved Resident of Palm Springs 3Health News:Bill Howe Plumbing, Heating & Air Launches Online Application to Prospective Employees 2Health News:Bill Howe Plumbing, Heating & Air Launches Online Application to Prospective Employees 3Health News:Hospitals Add Phone Charging Stations as an Amenity for Patients and Visitors 2Health News:Bill to Create Patient Registry for Deadly Cancer Introduced in Congress 2Health News:Florida Questions Its Spending on Punitive Incarceration in Light of Exorbitant Costs for Non Violent Offenders 2Health News:Florida Questions Its Spending on Punitive Incarceration in Light of Exorbitant Costs for Non Violent Offenders 3
... decades, hip replacement surgery has been the only treatment for ... younger patients may replace the traditional replacements.// ,Bobby Castor ... in grade school led to a condition called avascular necrosis. ... the hips drive a golf swing, it hurt Castor’s game. ...
... Laboratory research has found evidence that the venom that ... beneficial effects // on some heart problems, strokes, central ... involved the experimental drug ziconotide, a laboratory-made equivalent of ... Magus cone snail, which lives in shallow tropical saltwater. ...
... IGF-1 will increase substantially risks of breast, colon and ... hormone is a disaster waiting to happen. They say ... -- increases levels of insulin-like growth factor 1 (IGF-1). ... can do. ,Currently, human growth hormone is ...
... the drug gabapentin (Neurontin) taken at 2,400 milligrams ... for people with chronic daily headaches. ,Gabapentin is ... its success in treating other pain-related health issues ... Since gabapentin often reduces migraines by more than ...
... analyzed results from a questionnaire that included more than 4,400 ... the annual British Household Panel Survey, began in 1991. Results ... health, but marriage is better for a woman's . ,Researchers ... work out reported much poorer mental health than men who ...
... drug that strongly activates certain systems in the brain.// ... is often addictive. According to the 2000 National Household ... the United States have tried methamphetamine at least once ... methamphetamine users and 18 healthy people to determine how ...
Cached Medicine News:
Optical Urethrotome 8667 for telescope 4 mm, 0. For slitting urethral strictures under vision...
OES Pro Optical Urethrotome...
... With a 4.9mm insertion tube, ... and increases maneuverability even through strictured ... wide viewing angle of 125 in ... a large viewing area and simplifying ...
New technology in optics, processing and application. Laser-welded mechanics in stainless steel provide high safety in sterilization. Saphire windows distal and proximal, validated even for autoclavi...
Medicine Products: