AlphaVax Announces Initial Analysis of Data From CMV Phase 1 Clin...(ced in cell culture harvested and admini...),Health

Date:4/17/2008

ced in cell culture, harvested and administered to the volunteers at two dosage levels. A key design and safety feature of this single-cycle vaccine technology is that there is no further replication of the virus-like particles after the expression of the CMV proteins in the vaccine recipients.

About CMV

CMV is a herpesvirus that is a major cause of morbidity and mortality in congenitally infected infants and hematopoietic stem cell (HSCT) and solid organ transplant (SOT) recipients. Congenitally acquired CMV, the most common congenital infection in the United States, causes occasional mortality and significant morbidity in infants and young children (e.g., hearing loss and mental retardation). For healthy people who acquire CMV after the prenatal period, infection is life-long but typically asymptomatic. However, CMV reactivation or primary infection in HSCT and SOT recipients with suppressed or impaired immune systems can be life-threatening. In these patients, CMV infection is a major cause of disease, organ rejection, and death, with mortality rates among infected HSCT patients of 50% despite current anti-CMV drugs. Manifestations of CMV include pneumonia, hepatitis and gastrointestinal disease, usually occurring within the first 100 days after transplant.

About AlphaVax

AlphaVax, Inc. is a North Carolina-based, clinical-stage company that uses a novel alphavirus vector platform technology that has proven to be highly flexible and immunogenic, and allows the same manufacturing, formulation, and delivery strategies to be applied to many different products. The company employs staff with expertise spanning vaccine design, process development, GMP manufacturing, quality assurance, and regulatory and clinical affairs. In addition to cytomegalovirus, important disease targets include influenza, cancer, HSV, RSV, and a number of biodefense vaccine products. The AlphaVax headquarters and R&D facilities are located in Research Triangle Park,
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SOURCE AlphaVax, Inc. Copyright©2008 PR Newswire. All rights reserved

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