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Alpha-1 Foundation, AARC Cooperate on Study to Test 5,000 COPD Patients for Alpha-1
Date:12/6/2007

DENVER, Dec. 6 /PRNewswire/ -- Some 5,000 COPD patients will be tested to determine the prevalence of Alpha-1 Antitrypsin Deficiency (Alpha-1) in a study marking a major cooperative effort between the Alpha-1 Foundation and the American Association for Respiratory Care (AARC).

The principal investigator is Robert A. Sandhaus, MD, PhD, of the Division of Pulmonary Medicine, National Jewish Medical and Research Center in Denver. Sandhaus is also the Clinical Director of the Alpha-1 Foundation.

According to Sandhaus, "If the current literature is correct, the study should identify about 50 to 100 individuals who are unaware they have COPD due to Alpha-1. In addition, the study should identify about 300 people who are carrying a single abnormal Alpha-1 gene. All will be counseled about the potential risk to their children and family members."

Sandhaus points to an intriguing possibility. "If this study confirms what much smaller studies have suggested about Alphas hidden in the COPD population, there could be as many as 400,000 individuals in the US who have lung disease due to Alpha-1 and don't know it."

More than 12 million people have been diagnosed with COPD (Chronic Obstructive Pulmonary Disease), an umbrella term that includes emphysema and chronic bronchitis. COPD is the 4th leading cause of death in the United States, and is expected to be the third leading killer by 2020. Alpha-1, sometimes called "genetic COPD," is the most common known genetic risk factor for emphysema.

Sandhaus believes the study will demonstrate the effectiveness of using respiratory therapists to perform significant pulmonary clinical research.

"Respiratory therapists will have a critical role as more genetic factors (in lung, airway and sleep disorders) are identified," said Alpha-1 Foundation President and CEO John W. Walsh. "The expanding role of the RT in supporting the physician will accelerate early detection and access to appropriate
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SOURCE Alpha-1 Foundation
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