Navigation Links
Alpha-1 Foundation, AARC Cooperate on Study to Test 5,000 COPD Patients for Alpha-1
Date:12/6/2007

DENVER, Dec. 6 /PRNewswire/ -- Some 5,000 COPD patients will be tested to determine the prevalence of Alpha-1 Antitrypsin Deficiency (Alpha-1) in a study marking a major cooperative effort between the Alpha-1 Foundation and the American Association for Respiratory Care (AARC).

The principal investigator is Robert A. Sandhaus, MD, PhD, of the Division of Pulmonary Medicine, National Jewish Medical and Research Center in Denver. Sandhaus is also the Clinical Director of the Alpha-1 Foundation.

According to Sandhaus, "If the current literature is correct, the study should identify about 50 to 100 individuals who are unaware they have COPD due to Alpha-1. In addition, the study should identify about 300 people who are carrying a single abnormal Alpha-1 gene. All will be counseled about the potential risk to their children and family members."

Sandhaus points to an intriguing possibility. "If this study confirms what much smaller studies have suggested about Alphas hidden in the COPD population, there could be as many as 400,000 individuals in the US who have lung disease due to Alpha-1 and don't know it."

More than 12 million people have been diagnosed with COPD (Chronic Obstructive Pulmonary Disease), an umbrella term that includes emphysema and chronic bronchitis. COPD is the 4th leading cause of death in the United States, and is expected to be the third leading killer by 2020. Alpha-1, sometimes called "genetic COPD," is the most common known genetic risk factor for emphysema.

Sandhaus believes the study will demonstrate the effectiveness of using respiratory therapists to perform significant pulmonary clinical research.

"Respiratory therapists will have a critical role as more genetic factors (in lung, airway and sleep disorders) are identified," said Alpha-1 Foundation President and CEO John W. Walsh. "The expanding role of the RT in supporting the physician will accelerate early detection and access to appropriate care."

Thomas Kallstrom, AARC Chief Operating Officer, is the study coordinator for the AARC. "The involvement of respiratory therapists in this process is a natural relationship," Kallstrom said. "We're proud to be part of this monumental study."

The Alpha-1 Foundation and the AARC cooperated to propose, design and run the study, which will enroll 5,000 people at 15 academic sites around the United States. To be eligible, a patient must have been referred for pulmonary function testing at the site. Any patient meeting COPD criteria (as defined by GOLD, the Global Initiative for Chronic Obstructive Lung Disease) will be offered enrollment in the study.

The study requires only about 30 minutes of the subject's time, and participants will receive the results. If they are positive for Alpha-1, they will receive educational information about the condition and will be encouraged to call a toll-free number to speak with the Alpha-1 genetic counselor at the Medical University of South Carolina.

Epidemiology and AAT genotyping for the study will be done at the University of Florida Alpha-1 Genetics Laboratory run by Mark L. Brantly, MD. Data coordination and statistical analysis will be done by James Murphy, PhD, at National Jewish.

Jorge Zamudio, MD, is the Alpha-1 Foundation coordinator.

The study is supported in part by an unrestricted charitable contribution from Talecris Biotherapeutics.
Available Topic Expert(s): For information on the listed expert(s), click appropriate link. Mark Brantly http://profnet.prnewswire.com/Subscriber/ExpertProfile.aspx?ei=54431 Charlie Strange http://profnet.prnewswire.com/Subscriber/ExpertProfile.aspx?ei=54427 Michael Campos http://profnet.prnewswire.com/Subscriber/ExpertProfile.aspx?ei=54425 Adam Wanner http://profnet.prnewswire.com/Subscriber/ExpertProfile.aspx?ei=54278 Robert Sandhaus http://profnet.prnewswire.com/Subscriber/ExpertProfile.aspx?ei=54274 John Walsh http://profnet.prnewswire.com/Subscriber/ExpertProfile.aspx?ei=54964 Edwin Silverman http://profnet.prnewswire.com/Subscriber/ExpertProfile.aspx?ei=69223 Byron Thomashow http://profnet.prnewswire.com/Subscriber/ExpertProfile.aspx?ei=69327


'/>"/>
SOURCE Alpha-1 Foundation
Copyright©2007 PR Newswire.
All rights reserved

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
4. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
5. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
6. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
7. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
8. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
9. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
10. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
11. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/8/2017)... June 8, 2017   Responding to Heath Ledger,s ... the death of singer Chris Cornell in May, ... International offers a free online psychiatric drug ... and families about psychotropic drug risks. The ... died from an accidental overdose, has called for tighter rules ...
(Date:6/5/2017)... The Cincinnati location of ... (NYSE: DPLO), has been awarded a Top Workplaces 2017 ... Results are based on an employee survey administered by WorkplaceDynamics, ... improvement. The survey measures several aspects of workplace culture, including ... ...
(Date:5/30/2017)... Corp. (NASDAQ: DRIO), a leading global digital health company with mobile ... presenting at the 7th annual LD Micro Invitational on Tuesday, June ... of DarioHealth will be giving the presentation and meeting with investors. ... 7th, 2017 at the Luxe Sunset Bel Air Hotel and will ... About LD Micro LD Micro was founded ...
Breaking Medicine Technology:
(Date:6/23/2017)... ... June 23, 2017 , ... "The Better ... ultimately do significant harm to people with all chronic conditions, including mental illnesses, ... leaves in place the Affordable Care Act (ACA) requirement that insurers cover pre-existing ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Military Officers Association of America ... secretary of Veterans Affairs, retired Marine Col. Thomas G. Bowman. , Bowman currently serves ... Bowman brings an intimacy with the issues and challenges veterans face with the VA. ...
(Date:6/23/2017)... ... , ... Goodcents Deli Fresh Subs today announced the opening of a new ... St. Topeka, Kan. 66604 (near 21st and Gage). It is owned and operated by ... locations in the Topeka and Bonner Springs, Kan. area. , “Goodcents has such ...
(Date:6/23/2017)... ... ... 21 Middle East and South Asia Leaders Selected as Eisenhower Fellows , ... society in 11 countries across the Middle East and South Asia to embark on ... knowledge and ideas with the leading minds in their fields. , For the ...
(Date:6/23/2017)... ... , ... American Farmer, will feature Chr. Hansen, Inc (CHR Hansen) in an ... 2017. American Farmer airs Tuesdays at 8:30aET on RFD-TV. Check your local listings for ... Denmark in 1874 after a groundbreaking discovery of how to industrialize enzymes. Rooted in ...
Breaking Medicine News(10 mins):