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Algeta Completes Comprehensive Phase II Clinical Program With Alpharadin for Treating Bone Metastases in Patients With Advanced Prostate Cancer
Date:1/14/2009

OSLO, Norway, January 14 /PRNewswire-FirstCall/ --

- Results Highlight the Potential of Alpharadin to Treat Bone Metastases in Major Cancer Indications

Algeta ASA (OSE: ALGETA), the cancer therapeutics company, announces that with the results of the BC1-04 study reported today it has completed its comprehensive phase II clinical program evaluating Alpharadin (radium-223) as a new treatment for bone metastases in patients with hormone-refractory prostate cancer (HRPC). The program provides strong evidence that Alpharadin can prolong patient survival times, improve quality of life and offer a placebo-like safety profile.

These exciting clinical results combined with Alpharadin's unique bone-targeting properties highlight the potential of this new cancer therapeutic to be a first-choice treatment for bone metastases that frequently arise from a number of high incidence cancers as well as HRPC (e.g. breast, lung and thyroid). Bone metastases are a serious consequence of certain advanced cancers causing intractable and debilitating pain as well as further reducing life expectancy.

In addition, the results, including data from the final trial in the program (BC1-04; outlined below), suggest that Alpharadin has an ideal profile to be used in combination with other cancer therapies.

The Alpharadin phase II program comprised three trials and involved 286 individuals. It was designed to provide detailed information on the safety and therapeutic efficacy of different doses of Alpharadin in HRPC patients, both symptomatic and asymptomatic for bone metastases, as well as evaluating its ability to relieve pain caused by bone metastases in symptomatic patients. In all three phase II trials completed, the primary efficacy endpoints were met while providing compelling evidence of the benign, placebo-like safety profile of Alpharadin. In addition, data from the BC1-04 study suppo
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