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Alfacell Provides Shareholder Update
Date:6/19/2009

SOMERSET, N.J., June 19 /PRNewswire-FirstCall/ --

Dear Shareholder,

I am grateful to have this opportunity to share with you important developments taking place at this critical juncture in our company history. This communication shall mark what I hope will be the first of many as your president.

Like many of you, I also have been a longtime shareholder and supporter of this company. I want you to know I am fully committed no matter how difficult the challenge, to see this company and our valuable compounds realize their full potential.

As you are aware, we did not meet our primary endpoint of overall survival in our Phase IIIb clinical trial in patients suffering from unresectable malignant mesothelioma (UMM). We did however; achieve statistical significance with a subgroup of patients who failed a prior chemo therapy. Overall survival was 10.5 months for this group. As we reported in January 2009, we had a pre-NDA meeting with the FDA and the FDA provided guidance to the company recommending that an additional trial be conducted in UMM patients that have failed at least one prior chemotherapy regimen prior to submitting an NDA. Considering Onconase's overall safety profile, its ability to overcome MDR, I believe that Onconase remains a viable candidate for second line therapy in MM.

The fact that Onconase was able to extend the lives of patients who had failed a prior chemo therapy was not lost in our thoughts. About a year ago, we engaged Champions Biotechnology, to conduct a series of animal studies on immune deficient mice to see what effect Onconase would have on human tumors grafted onto these mice. Tumorgrafts parallel sensitivity and resistance in the clinic. The results showed Onconase has a documented synergistic effect in Cisplatin sensitive and resistant NSCLC. We are not surprised by these results and believe Onconase has the potential to overcome multipl
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SOURCE Alfacell Corporation
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