Navigation Links
Alexza's AZ-104 (Staccato(R) Loxapine) Phase 2a Trial Meets Primary Endpoint of 2-Hour Pain Relief in Patients with Migraine Headache
Date:3/3/2008

duration of efficacy is the sustained pain-free response, in which a patient reports a pain-free score at the 2-hour post-dose time point and remains pain-free for the remainder of the study period (up to 24 hours). The 2.5 mg dose of AZ-104 showed a statistically significant difference in sustained pain-free response (26%, p = 0.04) compared to placebo (8%). Sustained pain-free outcomes for the 5 mg (16%) and the 1.25 mg (21%) dose groups were not statistically significant.

Important symptoms to be managed in migraine patients are nausea, photophobia (sensitivity to light) and phonophobia (sensitivity to sound). This proof-of-concept trial was not powered to detect differences in these measurements. AZ-104 did exhibit statistically significant improvement in nausea across all dose levels (survival analysis, p = 0.02). Positive trends were observed in the improvement of the other symptoms, but the changes were not statistically significant.

Safety Evaluations

Side effects were recorded throughout the clinical trial study period. There were no serious adverse events reported during the trial. The most common drug-related side effects (incidence . 5% in at least one drug dose
group) reported across the three drug dose groups and placebo are listed in the table below.

Placebo 1.25 mg 2.5 mg 5 mg

Side Effects (%) (%) (%) (%)

Dysgeusia 13 19 23 37

Somnolence 13 5 23 23

Fatigue 8 0 7 14

Oral discomfort 3 0 2 7

Dizziness 5 2 7 2

Hypoaesthesia,

pharyngeal 0 0 0 7

Throat irritation
'/>"/>

SOURCE Alexza Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Alexza Completes Target Enrollment in AZ-104 Phase 2a Clinical Trial in Migraine Patients
2. Alexza Initiates AZ-007 (Staccato(R) Zaleplon) Phase 1 Clinical Trial and Updates Clinical Pipeline Development Status
3. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
4. Thomson Scientific Publishes The Ones to Watch - A Quarterly Review of Phase Changes in the Pharmaceutical Pipeline
5. Progen Engages Leading CRO to Assist with Phase 3 Trial of PI-88
6. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
7. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
8. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
9. Positive Kuvan(TM) Pivotal Phase 3 Trial Results Published in The Lancet
10. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
11. TaiGen Biotechnology Successfully Completes Patient Recruitment for Phase II Trial of Nemonoxacin for Treatment of Adult Community Acquired Pneumonia (CAP)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... DIEGO and CARDIFF-BY-THE-SEA, Calif. ... Inc. (NASDAQ: SRNE ;  Sorrento), an ... associated pain, and Conkwest, Inc., a privately-held immuno-oncology ... Natural Killer (NK) cell-line based therapy, announced today ... agreement to jointly develop next generation CAR-TNK™ (pronounced ...
(Date:12/19/2014)... 2014  Decision Resources Group finds that the laparoscopic ... will increase to a value of over $4.3 ... expansion in the large direct energy device market. In ... adopted due to the advantages they offer and as ... from Decision Resources Group,s coverage of the U.S. laparoscopic ...
(Date:12/19/2014)... CITY, Kan. , Dec. 18, 2014 /PRNewswire/ ... PETX ), a biopharmaceutical company focused on the ... companion animals, today announced positive results from its ... innovative drug for treating pain in dogs with ... improvements in pain assessment scores that were statistically ...
Breaking Medicine Technology:Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 2Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 3Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 4Aratana Therapeutics Announces Positive Top-Line Results from AT-001 Pivotal Field Study in Client-Owned Dogs with Osteoarthritis 5
(Date:12/22/2014)... DC (PRWEB) December 22, 2014 ... its year-long, professional development programs this month. Faculty ... which focuses on nurse educators fast-tracked for administrative ... the Leadership Development Program for Simulation Educators, featuring ... specialized area of nursing education. , Twenty ...
(Date:12/22/2014)... 22, 2014 Parker & Sons, Inc. ... in Arizona home contracting services reports a record number ... quality services in 2014. As a company that has ... 1970s, Parker and Sons is a business that is ... works side-by-side with other top quality companies in Arizona ...
(Date:12/21/2014)... (PRWEB) December 22, 2014 Recently, BambooFlooringChina.com, ... durable strand woven bamboo flooring collection , and launched ... 25%. The promotion is valid until Jan. 30, 2015. ... woven bamboo is the hardest bamboo flooring available today; ... resembling that of traditional teak hardwoods. Strand woven bamboo ...
(Date:12/21/2014)... BellasDress.com offers a wide range of women’s dresses, ... its BellasDress Christmas Sale , offering big discounts ... BellasDress is a famous online supplier of women’s dresses; ... series of promotions. The dress experts of the company ... are proud of offering high quality wedding dresses and ...
(Date:12/21/2014)... 21, 2014 When families in Coral Gables ... they call? The new answer is Lice Troopers . ... 33134, their newest treatment center will be the new go-to ... and without the use of harmful chemicals or pesticides. ... January 1, 2015. Like the company’s first clinic (located at ...
Breaking Medicine News(10 mins):Health News:NLN Leadership Institute Announces 2015 Cohorts 2Health News:NLN Leadership Institute Announces 2015 Cohorts 3Health News:Parker & Sons Reports A Record Number Of Favorable References With Regard To Its Quality Services In 2014 2Health News:Parker & Sons Reports A Record Number Of Favorable References With Regard To Its Quality Services In 2014 3Health News:BambooFlooringChina.com Announced Its Durable Strand Woven Bamboo Flooring Collection 2Health News:BellasDress.com Announces its BellasDress Christmas Sale 2Health News:All-Natural Florida Lice Removal Company Opens New Lice Treatment Salon In South Florida 2
... , Working Together to Share Records Safely, Improve ... of Veterans Affairs (VA) and Kaiser Permanente today announced an ... Nation,s heroes. VA and Kaiser Permanente are launching a pilot ... Nationwide Health Information Network (NHIN) created by the Department of ...
... ... of Feeding America,s SNAP Outreach Efforts , CHICAGO, Nov. 25 ... $1 million donation from the Bank of America Charitable Foundation to ... Nutrition Assistance Program (SNAP), formerly named the Food Stamp Program. ...
... to normal human development - the Wnt/Wingless (Wnt) and ... ways that can promote tumor cell invasion and metastasis, ... Cancer Center report in the Nov. 25 issue of ... involves three signaling components known to correlate with invasive ...
... Melvin R. Kaplan, MD, FACP, a former Board Chair ... became Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center ... Physicians for his lifetime devotion to the care of patients. ... American College of Physicians will present Dr. Kaplan with the ...
... 2009 Physicians at UT Southwestern Medical Center soon will ... patients with upper spinal-cord injuries or other diseases that keep ... St. Paul is only one of only two sites ... equipped to implant the device, called the NeuRx Diaphragm Pacing ...
... mitochondrial function plays in insulin production , WEDNESDAY, ... people with type 2 diabetes to lose insulin-producing ... treatments, U.S. researchers say. , Mitochondria provide energy ... when insulin-producing beta cells in the pancreas can,t ...
Cached Medicine News:Health News:VA and Kaiser Permanente Invite Veterans to Participate in Health Record Pilot Program 2Health News:Bank of America Charitable Foundation Presents $1 Million Contribution to Feeding America in an Effort to Help Connect Low-Income Americans With Federal Nutrition Programs 2Health News:Bank of America Charitable Foundation Presents $1 Million Contribution to Feeding America in an Effort to Help Connect Low-Income Americans With Federal Nutrition Programs 3Health News:Crosstalk between critical cell-signaling pathways holds clues to tumor invasion and metastasis 2Health News:Crosstalk between critical cell-signaling pathways holds clues to tumor invasion and metastasis 3Health News:1 of LA BioMed's founders to be honored 2Health News:New device implanted by surgeons help paralyzed patients breathe easier 2
Slick® Disposable Endotracheal Stylet, Nylon-coated wire, Malleable core, Sureloc Stop helps maintain desired length for patient safety. Handle forming capability for better grip. Sterile. Single...
... spine manipulation. Prevent dental and soft tissue ... alternative to X-ray. Light-guided intubation is based ... in the neck. This technique takes advantage ... relative to the esophagus. A well-defined, circumscribed ...
... of flexible lighting products. The first is ... different sizes 5", 10", and 15" (refers ... light). These lights are for use in ... ,The second group of flexible lights is ...
... of flexible lighting products. The first is ... different sizes 5", 10", and 15" (refers ... light). These lights are for use in ... ,The second group of flexible lights is ...
Medicine Products: