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Alexza Provides Pipeline Update
Date:7/31/2014

er currently available options for treating these symptoms.  Alexza believes that rapidly treating the acute symptoms could address a need in RLS patients for whom the acute symptoms can seriously impair quality of life.

AZ-009 (Staccato ropinirole) for Hypomobility in PD
According to the Parkinson's Disease Foundation, as many as one million people in the United States live with PD, which is a progressive neurodegenerative disorder that is characterized by a broad spectrum of motor and non-motor features that can have an impact on the function of the patient.   One of these clinical features is acute and intermittent hypomobility, or freezing, during "off periods", which tends to manifest in the more advanced patients. 

Freezing is a form of akinesia (loss of movement) and is one of the most disabling symptoms of PD.  It may occur in about half of PD patients and according to Alexza's physician survey (n=111), can occur at any time of the day, and multiple times per day or week depending on the patient.  Freezing most commonly affects the legs during walking, and because of this, is a common cause of falls, which can cause substantial social and clinical consequences for patients.  Alexza's interviews with neurologists who specialize in treating PD describe a freezing episode as unpredictable and sudden, and lasting 10 to 30 minutes.  Although these freezing episodes can be mitigated by treatment with dopamine agonists, only oral and injectable treatment options are currently available for patients to treat themselves at home.

According to neurologists Alexza surveyed (n=111) who specialize in treating these patients, AZ-009 could play a role in treating the PD population that is currently underserved with current treatment options for freezing.  According to the physicians Alexza surveyed, speed of onset of treatment is considered crucial in treating the
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SOURCE Alexza Pharmaceuticals, Inc.
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