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Alexza Provides Pipeline Update
Date:7/31/2014

a 3% mortality rate in children and 26% in adults. 

Alexza plans the first clinical trial with AZ-002 to be a Phase 2a proof-of-concept study.  The Phase 2a clinical trial is planned to be an in-clinic, randomized, double-blind, evaluation of patients with epilepsy.  The primary aim of this study will be to assess the safety and pharmacodynamic electroencephalographic effects of a single dose of AZ-002 at different dose strengths.  Data from this clinical trial are expected to serve as the basis for dose determination in potential future efficacy and safety clinical studies.  The Company owns full development and commercial rights to AZ-002. 

AZ-008 (Staccato ropinirole) for Acute Treatment of RLS
RLS affects 2-3% of the adult U.S. population.  RLS is characterized by restlessness in the legs, which can be accompanied by uncomfortable sensations, such as leg cramps, and an urge to move the legs.  Symptoms start at rest and commonly worsen at night.  About 80% of people with RLS have periodic limb movements of sleep, which can cause nighttime arousals, and reduce the quality and quantity of sleep.  In an acute situation, RLS may delay sleep, and can negatively affect quality of life.

Alexza believes AZ-008 could play a role in treating acute and episodic or breakthrough RLS symptoms in patients who may or may not be taking chronic treatment.  Alexza believes the benefits of AZ-008 may include: (i) rapidly treating acute symptoms when they occur at night, which may allow patients to calm their legs and go to or get back to sleep; and (ii) providing an acute treatment option for patients who are not yet taking chronic treatment and deferring starting chronic, maintenance therapy that can lead to augmentation of RLS symptoms.  Forty-one percent of physicians surveyed in Alexza's market research (n=114) see this product candidate as a potential significant improvement ov
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SOURCE Alexza Pharmaceuticals, Inc.
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