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Alexza Provides Pipeline Update
Date:7/31/2014

MOUNTAIN VIEW, Calif., July 31, 2014 /PRNewswire/ -- Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA) today provided an update on its pipeline and new product development efforts. In the second half of 2014, Alexza expects to initiate a Phase 2a study of AZ-002 (Staccato® alprazolam), which is being developed for the management of patients with acute repetitive seizures.  Additionally, Alexza has identified two new Staccato-based product candidates for development - AZ-008 and AZ-009 - which will incorporate the active pharmaceutical ingredient ropinirole, a dopamine agonist, into Alexza's proprietary Staccato system.  The Company plans to develop AZ-008 for the acute treatment of restless legs syndrome (RLS) and AZ-009 for hypomobility, or freezing, during "off periods" in Parkinson's disease (PD) patients.

"We have made good progress towards initiating the AZ-002 Phase 2a proof-of-concept study in epilepsy patients and plan to enroll the first patient in the second half of 2014," said James V. Cassella, PhD, Executive Vice President, Research and Development and Chief Scientific Officer of Alexza.  "We have been working with key opinion leaders in this field to finalize the protocol and our overall development strategy, and we look forward to being back in the clinic with AZ-002."

Cassella continued, "On the pipeline side, over the last nine months we have conducted a broad review of medical need in major therapeutic areas.  Through this process, we identified a number of product concepts that aligned with our Staccato technology.  We selected Staccato ropinirole as the basis of the next product candidates planned in our pipeline, based upon our belief of the need for better therapies for patients with RLS or PD.  We feel that AZ-
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