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Alexza Pharmaceuticals Updates Staccato® Pipeline and Outlines Pipeline Development Strategy
Date:7/12/2010

igh purity.  These findings, in combination with Alexza's electronic multiple-dose Staccato platform, provide the technical rationale for possible smoking cessation therapeutics.  

The therapeutic area of smoking cessation is primarily consumer product focused and not in Alexza's current development focus.  Following the tradition of other technology-based Dr. Zaffaroni-founded companies, Alexza has formed Addicere Therapeutics to focus on the development of smoking cessation therapies based on the Staccato electronic multi-dose technology.  Addicere is pursuing independent funding to develop Staccato nicotine, either through a traditional venture capital financing or through a partnering collaboration.  Alexza intends to maintain a minority share holding in Addicere, post-financing, to allow Alexza stockholders a chance to participate in future successes in the development of Staccato nicotine.

Addicere plans to develop Staccato nicotine to address both the chemical and behavioral components of nicotine addiction by combining nicotine replacement with a user-friendly drug delivery device that will help smokers reduce or eliminate their smoking habit.  Addicere believes the Staccato technology is capable of mimicking the pharmacokinetics of smoking cigarettes through the delivery of optimally-sized nicotine particles to the deep lung.  Staccato nicotine may also provide some of the psychological aspects of smoking (e.g., hand-to-mouth movement, oral inhalation) and could allow smokers to self-administer and possibly titrate to the dose to treat cravings.  Importantly, the electronics embedded within the Staccato delivery system could allow for the programmed, over-time reduction in the overall daily dose of nicotine, and ultimately may lead to the better management of nicotine cravings and eventual sustained
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SOURCE Alexza Pharmaceuticals, Inc.
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