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Alexza Pharmaceuticals Updates Staccato® Pipeline and Outlines Pipeline Development Strategy
Date:7/12/2010

rd to continuing to expand our development pipeline in the coming months and years, as we execute this dual-tracked development strategy to take advantage of the strength and breadth of the Staccato technology platform."

About AZ-007 (Staccato zaleplon)

Alexza is developing AZ-007 (Staccato zaleplon) for the treatment of insomnia in patients who have difficulty falling asleep, including those patients who awake in the middle of the night and have difficulty falling back asleep.  Zaleplon, a non-benzodiazepine hypnotic currently approved to treat insomnia, has a pharmacokinetic half-life of about one hour and is generally well tolerated in patients.

"We have combined the technology attributes of our Staccato system with the known pharmacology of zaleplon, in order to develop a product candidate with a specific profile for middle of the night insomnia.  When patients wake up in the middle of the night, they need a rapidly-acting drug with a short half-life to assist them in the return to sleep and to minimize residual or next-day effects," said James V. Cassella, PhD, Alexza Senior Vice President, R&D.  "With AZ-007, we expect to see a rapid and predictable onset of therapeutic action resulting from Staccato administration, and a short-lived duration of action resulting from the pharmacological half-life of zaleplon."

Middle-of-the-night insomnia (MOTN) is insomnia characterized by difficulty returning to sleep after awakening either in the middle of the night, or too early in the morning.  It has been reported that waking up in the middle of the night is the most frequently reported insomnia symptom, with one large study finding that approximately 35% of Americans over 18 reported waking up three or m
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SOURCE Alexza Pharmaceuticals, Inc.
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