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Alexza Executes $15 million Working Capital Loan with Hercules Technology Growth Capital, Inc.
Date:5/5/2010

ic onset that is comparable to intravenous administration, but with greater ease, patient comfort and convenience.  

AZ-004 (Staccato loxapine) is Alexza's lead program, which is being developed for the rapid treatment of agitation in schizophrenic or bipolar disorder patients.  Alexza has completed and announced positive results from both of its AZ-004 Phase 3 clinical trials, submitted a New Drug Application submission in December 2009, and has a Prescription Drug User Fee Act (PDUFA) goal date of October 11, 2010.  In February 2010, Alexza established a partnership with Biovail Laboratories International SRL, a subsidiary of Biovail Corporation, to develop and commercialize AZ-004 in the U.S. and Canada.

Alexza has completed an end-of-Phase 2 meeting with the FDA for AZ-001 (Staccato prochlorperazine) and has completed two Phase 2 studies with AZ-104 (Staccato loxapine, low-dose). Both product candidates are being developed for the acute treatment of migraine headache.  

AZ-002 (Staccato alprazolam) has completed Phase 1 testing and one Phase 2a proof-of-concept clinical trial.  Product candidates that have completed Phase 1 testing are AZ-003 (Staccato fentanyl) for the treatment of breakthrough pain, and AZ-007 (Staccato zaleplon) for the treatment of insomnia.  More information, including this and past press releases from Alexza, is available online at www.alexza.com.

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Related medicine technology :

1. Alexza Pharmaceuticals Files Shelf Registration Statement
2. Alexza to Announce 2010 First Quarter Financial Results on Monday, May 10, 2010
3. Alexza Reports 2009 Fourth Quarter and Full Year Financial Results and Provides General Corporate Update
4. Alexza Pharmaceuticals Promotes Mark K. Oki to Vice President, Finance and Controller
5. Alexza Pharmaceuticals to Host 2010 Investor/Analyst Day on Thursday, February 18, 2010
6. Alexza Announces AZ-004 (Staccato(R) Loxapine) PDUFA Goal Date of October 11, 2010
7. Alexza Announces Submission of AZ-004 (Staccato(R) Loxapine) NDA
8. Alexza Pharmaceuticals to Present at the 21st Annual Piper Jaffray Health Care Conference
9. Alexza to Announce 2009 Third Quarter Financial Results and Update Its AZ-004 NDA Status on Monday, November 9, 2009
10. Alexza Pharmaceuticals to Present at the Fourth Annual JMP Securities Healthcare Focus Conference
11. Alexza Announces Preliminary Results from its AZ-104 (Staccato(R) Loxapine) Phase 2b Trial in Patients with Migraine Headache
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