Navigation Links
Alexza Announces Positive Phase 1 Results With AZ-007 (Staccato(R) Zaleplon)
Date:4/29/2008

howed onset of effect as early as 2 minutes after dosing with AZ-007.

There were no serious adverse events. The most frequently reported adverse events in subjects receiving AZ-007 were dizziness and somnolence. These data indicate a rapid onset of effect, apparently directly related to the IV-like pharmacokinetics, and showed that AZ-007 was generally safe and well tolerated in this population of healthy volunteers.

About Insomnia

Insomnia is a prevalent disorder that drives a multi-billion dollar market of prescription medications each year. An estimated 10 to 30% of the U.S. population experiences either chronic or occasional insomnia. In 2005, one survey conducted by the National Sleep Foundation showed that 54% of the respondents experienced a minimum of one symptom of insomnia at least a few nights a week. Of those, respondents complained primarily of waking up feeling unrefreshed (38%), waking up frequently during the night (32%), having difficulty falling asleep (21%), and waking up too early and not being able to get back to sleep (21%). There is a potentially significant clinical need for rapid and predictable onset of sleep in patients with insomnia, as well as a predictable duration of sleep and rapid, clear awakening.

About AZ-007 (Staccato zaleplon)

AZ-007 is the combination of Alexza's proprietary Staccato system with zaleplon, a drug belonging to the class of compounds known generally as hypnotics. The Staccato system technology is a hand-held, chemically-heated, single dose inhaler designed to generate and deliver excipient-free drug aerosol for deep lung delivery that results in IV-like pharmacokinetics.

The Company believes that AZ-007 may provide rapid sleep onset. Moreover, by coupling the shorter half-life of zaleplon with the lower dose enabled by the Staccato system technology, the overall product profile may match well with an unmet clinical need for patients with insomnia.

About Alexza Pharma
'/>"/>

SOURCE Alexza Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Alexza Completes Target Enrollment in AZ-104 Phase 2a Clinical Trial in Migraine Patients
2. Alexza Initiates AZ-007 (Staccato(R) Zaleplon) Phase 1 Clinical Trial and Updates Clinical Pipeline Development Status
3. Alexzas AZ-104 (Staccato(R) Loxapine) Phase 2a Trial Meets Primary Endpoint of 2-Hour Pain Relief in Patients with Migraine Headache
4. Alexza Reports 2007 Year-End Financial Results and Updates Clinical Pipeline Status
5. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
6. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
7. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
8. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
9. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
10. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
11. Xenomics Announces Implementation of its First Diagnostic Test for Acute Myeloid Leukemia Into Clinical Practice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... , Oct. 18, 2014  In a ... Rights Campaign (HRC), the nation,s largest lesbian, gay, ... endorsed the use of Truvada for Pre-Exposure Prophylaxis ... tool used to prevent the spread of a ... the only brand name anti-HIV drug combination currently ...
(Date:10/17/2014)...  Amgen (NASDAQ: AMGN ) today announced ... president of Gladstone Institutes and Gladstone,s Robert W. and ... are pleased to welcome Dr. Sandy Williams ... , chairman and chief executive officer of Amgen. "Dr. ... his direct experience in our industry will both be ...
(Date:10/17/2014)... According to the ... (Optical Coherence Tomography, Hyperspectral Imaging, Photoacoustic Tomography), Product ... Oncology, Cardiology) - Global Forecasts to 2019" ... Imaging market over the forecast period of ... million in 2014 and is expected to ...
Breaking Medicine Technology:HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 2HRC Endorses PrEP, Calls for Bold Action to Expand Access to Anti-HIV Drug 3Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 3Optical Imaging Market Worth $1,669.2 Million by 2019 2Optical Imaging Market Worth $1,669.2 Million by 2019 3Optical Imaging Market Worth $1,669.2 Million by 2019 4
... 7, 2011 Transgenomic, Inc. (OTC/BB: TBIO) today announced ... Transgenomic, will be presenting at the Rodman & Renshaw ... 11:40 AM Eastern Time at the Waldorf=Astoria Hotel in ... webcast live at http://www.wsw.com/webcast/rrshq20/tbio and is available ...
... 7, 2011 Endo Pharmaceuticals (Nasdaq: ENDP ) ... financial officer will present a corporate overview at the UBS ... 10:30 a.m. ET.  The conference will be held at the ... A live webcast and audio archive of the presentation will ...
Cached Medicine Technology:
(Date:10/20/2014)... Punzoné , the first line of ultra-premium organic ... to celebrate this month. October marks Italian Heritage Month – ... of Americans of Italian heritage and Italians in America. October ... its favorite Italian cocktails and encourages everyone to enjoy its ... it is only in a glass. , Punzoné continues ...
(Date:10/19/2014)... 20, 2014 Hastings and Hastings, a ... of service throughout the greater Phoenix area and across ... with regard to catastrophic automobile accidents. Statistics have indicated ... and throughout Arizona. As such, Hastings and Hastings has ... representation for those who have been injured through no ...
(Date:10/19/2014)... Dr. Babatunde Osotimehin, Executive Director of ... a ceasefire agreement that is expected to lead to ... were kidnapped from the north-eastern Nigerian town of Chibok—the ... enough, and it is high time they are returned ... , "We owe it to these girls to positively ...
(Date:10/19/2014)... Recently, Top10BestSEOHosting.com has unveiled its newest hosting ranking ... are the best VPS hosting suppliers in the ... method of partitioning a physical server computer into ... and capabilities of running on someone’s own dedicated ... attention to VPS products and related suppliers. ...
(Date:10/19/2014)... Visual Impact Frequency Training - ... released to the public generating a frenzied buzz ... fitness community. The commotion surrounding the program's launch ... prompting an investigative review. , "Many gym-goers are ... commonly known as a training 'plateau' where they ...
Breaking Medicine News(10 mins):Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 2Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 3Health News:Celebrate Italian Heritage Month With Authentic Cocktails from Punzoné: The Only Ultra Premium Line of Organic Imported Italian Vodka 4Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 2Health News:Hastings And Hastings Reports Record Demand In 2014 For Legal Representation With Regard To Catastrophic Automobile Accidents 3Health News:The Best VPS Hosting Suppliers In The Market Unveiled By Top10BestSEOHosting.com 2Health News:Visual Impact Frequency Training Review: Rusty Moore's Latest Fitness Guide Released 2
... The California,State Board of Pharmacy yesterday announced ... the implementation of E-Pedigree from,January 1, 2009 to ... and trace,technology designed to strengthen the chain of ... from entering the,marketplace., The decision coincides with ...
... The UC Irvine Department of Emergency Medicine is hosting ... Forum March 28-29 in Costa Mesa, Calif. As part ... present research findings on a variety of related areas ... services to the success of computerized alcohol-use counseling. , ...
... March 26 BD (Becton,Dickinson and Company) (NYSE: ... webcast of its second fiscal quarter 2008 earnings conference ... BD will issue a press release,detailing the quarter,s earnings ... call will be accessible through BD,s,website at http://www.bd.com/investors ...
... conducted by University of Pittsburgh Alzheimers disease researchers ... that Pittsburgh Compound-B (PiB) binds to the telltale ... with Alzheimers disease. The finding is a significant ... diagnosis of Alzheimers disease in living patients. For ...
... 26 Target Data Research (TDR),President R.J. Slutz announced ... Forward fund raising campaign which will be held at ... support Step,N Forward and the Office of Public,Guardianship, Advanced ... quality of life and develop strategies to raise the ...
... to use new technique, CHICAGO, March 26 It ... Homewood, Illinois. On Sunday, she struggled with,double vision because of ... eye movement. On Monday, she became one of the first ... a newly developed,material called Onyx. On Wednesday she was back ...
Cached Medicine News:Health News:NCPA Statement on California's Delay of E-Pedigree Implementation 2Health News:UC Irvine researchers present latest findings at emergency medicine forum 2Health News:Study validates Pittsburgh Compound-B in identifying Alzheimer's disease brain toxins 2Health News:Study validates Pittsburgh Compound-B in identifying Alzheimer's disease brain toxins 3Health News:Revolutionary New Technique Uses Onyx to Fill Hard-To-Treat Aneurysms 2
... maintaining the ankle in functional alignment. Entire ... cushioning AliPlast™ foam liner. The cushioning air ... heel in a protective hammock, reducing ulceration ... bed from side-lying to supine. Only the ...
... 1978, the Aircast Air-Stirrup Ankle Brace has ... functional management of ankle injuries and has ... for its superior performance in helping to ... anatomically designed shells lined with the patented ...
... As a prophylaxis for deep vein ... effective combination of graduated sequential compression and ... thrombus formation by increasing venous ejection while ... VenaFlow System includes a pump with tube ...
... with the Aircast VenaFlow System (a prophylaxis ... three different styles: calf, foot, and thigh, ... is made from light, cool, comfortable material ... cuff may be placed directly against the ...
Medicine Products: