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Alexion Commences Dosing in AEGIS Registration Study of Soliris(R) (eculizumab) in Patients with PNH in Japan
Date:1/7/2008

ngth of URL, please copy and paste into

browser window.)

(2) Hillmen P, Young NS, Schubert J, et al. The complement inhibitor

eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med.

2006;355:1233-1243.

(3) Hill A, Platts PJ, Smith A et al. The incidence and prevalence of

paroxysmal nocturnal hemoglobinuria (PNH) and survival of patients in

Yorkshire [abstract]. Blood. 2006;108(11):985.

(4) Socie G, Mary J Yves, de Gramont A, et al. Paroxysmal nocturnal

haemoglobinuria: long-term follow-up and prognostic factors. Lancet

1996; 348:573-577.

(5) Parker C, Omine M, Richards S, et al. Diagnosis and management of

paroxysmal nocturnal hemoglobinuria. Blood. 2005;106:3699-3709.

(6) Hillmen P. Lewis SM, Bessler M, Luzzatto L, Dacie JV. Natural history

of paroxysmal nocturnal hemoglobinuria. N Engl J Med 1995; 333:1253-

1258.

(7) Johnson RJ, Hillmen P. Paroxysmal nocturnal hemoglobinemia: Nature's

gene therapy? J Clin Path: Mol Pathol. 2002;55:145-152.

(8) Wang, et al. Clinical significance of a minor population of

paroxysmal nocturnal hemoglobinuria-type cells in bone marrow failure

syndrome. Blood 2002;100:3897-3902.

(9) Iwanga, et al. Paroxysmal nocturnal haemoglobinuria clones in

patients with myelodysplastic syndromes. Brit J Haem. 1998; 102:465-

474.

(10) Maciejewski, et al. Relationship between bone marrow failure

syndromes and the presence of glycophosphatidyl inositol-anchored

protein-deficient clones. Brit J Haem. 2001;115:1015-1022.

(11) Hill A, Richards S, Hillmen P. Recent developments in the

understanding and management of paroxysmal nocturnal haemoglobinuria.

British Journal of Haematology 2007; 137:3, 181-192.


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