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Albireo Announces Positive Results in Patients With Chronic Idiopathic Constipation From a Phase IIb trial of A3309
Date:10/12/2010

a bowel movement that occurs in the absence of laxative, enema, or suppository usage during the preceding 24 hours.

Complete spontaneous bowel movement (CSBM): A CSBM is an SBM that is accompanied by the patient self-reporting a feeling of complete emptying of the bowel.

About A3309

A3309 is a therapeutic alternative with a novel mechanism of action developed for the treatment of CIC and IBS-C. A3309, which has minimal systemic exposure, modulates the re-uptake of bile acids by inhibiting the ileal bile acid transporter (IBAT or ASBT). This results in an increased concentration of bile acids in the colon which, in turn, increase fluid secretion and colonic motility. These physiological responses should provide benefits to patients with CIC and IBS-C without any effects on other parts of the gastrointestinal tract.

About Chronic Idiopathic Constipation (CIC) and constipation predominant IBS (IBS-C)

Chronic constipation is among the most common diseases, affecting approximately 15 % of the general population particularly women and the elderly population. Patients with CIC often experience hard and lumpy stools, straining during defecation and a sensation of incomplete evacuation, as well as discomfort and bloating. CIC adversely affects a person's quality of life and is associated with significant health care expenditure. Studies show that approximately 50 % of individuals with CIC are not satisfied with available treatments underscoring the unmet medical need in this area.

IBS-C is a disease characterized by a combination of abdominal pain and constipation. Throughout the world, about 10%-20% of adults have symptoms consistent with IBS, and most studies find a female predominance. IBS symptoms come and go over time, often overlap with other functional disorders, impair quality of life, and result in high health care costs. There is a high rate of dissatisfaction with available therapies.

About Albireo

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