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Albireo Announces Positive Results From a Study With A3309 in Patients With Chronic Constipation
Date:4/29/2010

onsistency improved.

In the poster describing the preclinical experiments, A3309 is identified as a highly potent and selective compound for the ileal bile acid transporter (IBAT or ASBT), ameliorating meal-induced constipation in dogs.

About A3309

A3309 is a therapeutic alternative with a novel mechanism of action developed for the treatment of chronic idiopathic constipation and Irritable Bowel Syndrome with constipation (IBS-C). A3309 modulates the re-uptake of bile acids by inhibiting the ileal bile acid transporter (IBAT or ASBT). This results in an increased concentration of bile acids in the colon which, in turn, increase fluid secretion and colonic motility. These physiological responses should provide benefits to patients with chronic constipation and IBS-C without any effects on other parts of the gastrointestinal tract.

About Chronic Constipation (CC) and IBS-C Irritable Bowel Syndrome with constipation (IBS-C)

Chronic constipation is among the most common diseases, affecting approximately 15 % of the general population in particular women and the elderly population. CC adversely affects a person's quality of life and is associated with significant health care expenditure. Studies show that approximately 50 % of individuals with CC are not satisfied with available treatments underscoring the unmet medical need in this area.

IBS-C is a disease characterized by a combination of abdominal pain and constipation. Throughout the world, about 10%-20% of adults have symptoms consistent with IBS, and most studies find a female predominance. IBS symptoms come and go over time, often overlap with other functional disorders, impair quality of life, and result in high health care costs. There is a high rate of dissatisfaction with available therapies
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SOURCE Albireo AB
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