Navigation Links
Albireo Announces Positive Results From a Study With A3309 in Patients With Chronic Constipation
Date:4/29/2010

ory to OTC drugs," said Hans Graffner, Chief Medical Officer at Albireo. "The Albireo team looks forward to advancing the development of A3309, a first-in-class compound with a novel mode of action, and to create a new tool in the therapeutic armamentarium for these patients with limited treatment options."

A3309 is currently being evaluated in a large Phase IIb study in chronic constipation enrolling approximately 180 patients in the US and further investigation of A3309's enhancement of large bowel transit is being conducted at the Mayo Clinic. Also, given the mode of action, A3309 may be beneficial in patients with dyslipidemia and a study to evaluate A3309 in patients with high cholesterol levels is conducted in Sweden. Results of these clinical studies will be available late this year and plans are to move forward into Phase III in chronic constipation during 2011.

About the Results Presented at DDW

In the randomized, double-blind, placebo-controlled, prospective dose-escalating study, 30 patients were administered placebo or A3309 in a dose range of 0.1 mg - 10 mg for 14 days. In addition to evaluating safety and tolerability, bowel habits and gastrointestinal symptoms from patient diaries and radiographic assessments of transit were used to assess the efficacy of A3309.

There were no serious adverse events reported and no patient discontinued the trial. Adverse events were evenly distributed across the different dose levels and no difference was observed compared to placebo.

The mode of action - inhibition of bile acid re-absorption in the small bowel - was clearly demonstrated by biomarker analysis and colonic transit was improved in the higher dose groups as was the number of bowel movements. In addition, stool c
'/>"/>

SOURCE Albireo AB
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Binder Biomedical, Inc. Announces the Release of the X-GRAFT(TM) Interspinous Device, as Part of Their QUANTUM(TM) Line of Spinal Allograft Devices, Manufactured at the University of Miami Tissue Bank
2. Synergetics USA Announces Conference Call
3. Roche Announces Joint Initiative to Train Healthcare Workers in Africas Fight Against Cancer
4. Perrigo Company Announces Quarterly Dividend
5. Onyx Pharmaceuticals Announces First Quarter 2010 Financial Results Teleconference and Webcast
6. ATS Medical Announces Participation in the 90th Annual Meeting of the American Association for Thoracic Surgeons
7. Volcano Announces Distribution Agreement With AngioScore for the AngioSculpt(R) PTCA Scoring Balloon Catheter in Japan
8. B. Braun Renal Therapies Division Announces Availability of Adimea
9. RedVision Announces Integrated Client Workflow Platform: TitleVision2 The Power of Two
10. Sangamo BioSciences Announces First Quarter 2010 Conference Call and Webcast
11. Sirion Therapeutics Announces Availability of Zirgan(TM) (ganciclovir ophthalmic gel) 0.15% for Ocular Herpes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... 30, 2015  Ardelyx, Inc. (NASDAQ: ARDX ), ... metabolic diseases, today announced that the Company will host ... 8:00 a.m.- 1:00 pm EDT in New ... senior management team will present an overview of the ... has completed Phase 2b clinical trials for the treatment ...
(Date:6/30/2015)... MIRAMAR BEACH, Fla. , June 30, 2015  July ... our country,s declaration of independence, and the spirit and people ... For Heroes Foundation has partnered with USA ... cards, to help increase funding for programs that empower independence ... across the country, and help more people afford their prescriptions. ...
(Date:6/30/2015)... 30, 2015  Egalet Corporation (Nasdaq: ... pharmaceutical company focused on developing, manufacturing and ... results from a Category 3 human abuse ... extended-release, oral oxycodone product candidate in late-stage ... severe enough to require daily, around-the-clock opioid ...
Breaking Medicine Technology:Ardelyx to Host Inaugural R&D Investor Day in New York City on July 14, 2015 2Hope For Heroes and USA Medical Card Make a Difference for Our Nation's Heroes 2Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 2Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 3Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 4Egalet Announces Top-Line Results from Oral Human Abuse Liability Study of Egalet-002 5
... Supply Company (LABSCO), the largest privately held supplier of ... office laboratories, reference labs and other non-acute care settings ... leadership team with the new appointment of George Willett ... Willett,s career has included over 17 years serving as ...
... 29, 2011 Faith Community Hospital recently joined the ranks ... meaningful use of electronic health records, becoming one of only ... July, according to a report from the Health IT Policy ... the National Coordinator for Health Information Technology (ONC-HIT). ...
Cached Medicine Technology:LABSCO Hires George Willett as New Vice President and Chief Financial Officer 2Faith Community Hospital Joins Meaningful Use Trailblazers 2Faith Community Hospital Joins Meaningful Use Trailblazers 3
(Date:6/30/2015)... Diego, CA (PRWEB) , ... June 30, 2015 ... ... brand, Liporidex, announced today a partnership with Knockout Zone Miami (KO ... Taekwondo, strength and conditioning specialist and CrossFit Coach, Diego de Vera. The partnership ...
(Date:6/30/2015)... ... June 30, 2015 , ... The campaign aims to make digestive wellness ... forms of digestive disorders over 70 million Americans face and inspiring readers to be ... tip-top shape. , The print component of “Digestive Wellness” is distributed within USA Today ...
(Date:6/30/2015)... ... ... It has become fairly common to purchase fresh broccoli at the grocery ... cooking. Throwing out radish greens, beet leaves and chard stalks is pretty typical, too. ... a little knowledge and practice to use them. Josie's Organics is setting ...
(Date:6/30/2015)... ... June 30, 2015 , ... When it comes to volunteering ... feel the associated costs will be too high. However, there are affordable programs to ... abroad experience at minimal cost. One such volunteer named Uzma Aishah, a student ...
(Date:6/30/2015)... Washington, CT (PRWEB) , ... June 30, 2015 ... ... students on Wednesday, June 24, 2015 amidst bright skies and inspirational words. ... with the cherished processional walk from the Glenholme building to the school’s Center ...
Breaking Medicine News(10 mins):Health News:Top Sports Nutrition Brand, Liporidex, Announces Partnership With Leading Boxing, CrossFit and MMA Gym, Knockout Zone of Miami 2Health News:Top Sports Nutrition Brand, Liporidex, Announces Partnership With Leading Boxing, CrossFit and MMA Gym, Knockout Zone of Miami 3Health News:Mediaplanet’s “Digestive Wellness” Campaign Urges You To Listen to What Your Stomach Is Telling You and Talk About It 2Health News:Whole Vegetable Cooking for Home Cooks: Josie's Organics Encourages Using All Parts of Vegetables – from Root to Stalk – Every Day 2Health News:Whole Vegetable Cooking for Home Cooks: Josie's Organics Encourages Using All Parts of Vegetables – from Root to Stalk – Every Day 3Health News:Whole Vegetable Cooking for Home Cooks: Josie's Organics Encourages Using All Parts of Vegetables – from Root to Stalk – Every Day 4Health News:Volunteers Transform Themselves and Their Resumes with Medical Volunteer Placements Abroad 2Health News:Volunteers Transform Themselves and Their Resumes with Medical Volunteer Placements Abroad 3Health News:The Glenholme School Graduates Its Class of 2015 2Health News:The Glenholme School Graduates Its Class of 2015 3Health News:The Glenholme School Graduates Its Class of 2015 4
... Provider Organizations (AAPPO) is launching a new initiative to ... those patients diagnosed with diabetes as well as ... leader, AAPPO today kicked off its new ACT on ... Champion better care, and empower their patients to Take ...
... Philadelphia-based company offering HIV positive consumers the latest ... of their innovative HIV progression test , HIVmirror(TM). ... site (http: www.hivmirror.com), empowers modern consumers and gives ... its role in their potential HIV disease progression. ...
... WASHINGTON, -- Medicare patients' ability to get in and see ... steep Medicare cut to physicians, according to a new ... survey, which jumpstarts a national campaign to stop next year's ... their responses paint a bleak picture for the future of ...
... previous studies have already revealed that stress boosts the ... a new study on mice has now shown ... increases. ,The study, reported online in the Proceedings ... Washington University School of Medicine in St. Louis, is ...
... CHICAGO, Pharmion Corporation today released interim findings from ... the company's third-generation synthetic anthracycline currently in ... cancer. ,These findings indicate favorable interim ... when comparing Amrubicin to the current treatment standard, ...
... radiation dose from radium and polonium found naturally in ... that from the caesium-137 soaked up by the leaves ... researcher has said. ,Constantin Papastefanou from the Aristotle ... leaves from across the country and calculated the average ...
Cached Medicine News:Health News:AAPPO Launches ACT on Diabetes Initiative to Promote Improved Diabetes Care 2Health News:HIVmirror, LLC Launching Breakthrough Genetic Product for HIV Positive Consumer 2Health News:New AMA Survey Finds Medicare Cuts Will Hurt Seniors 2Health News:New AMA Survey Finds Medicare Cuts Will Hurt Seniors 3Health News:Stress Protein Inactivation Cuts Alzheimer's Peptide in Mice 2Health News:Amrubicin Shows Encouraging Results for Small Cell Lung Cancer Treatment 2
... D-Type can combine a number of ... microplates on a simple to use ... is a multifunctional stand-alone device but ... robotic systems. Custom and standard add-on ...
Grab one and go, One of the smallest handheld oximeters available, Datex-Ohmeda s TuffSat is the ideal spot-check solution for hospital, home care, transport, and EMS. TuffSat comes fully loaded wi...
Smith & Nephew's CDS System is developed exclusively for discography., Developed exclusively for discography, it is the first system designed to measure true disc pressure and record real-time proce...
The Maxi-Therm® lite hyper-hypothermia water blankets from Cincinnati Sub-Zero take conductive warming and cooling therapy to a new, softer level. These blankets are soft, lightweight, and remai...
Medicine Products: