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Albireo Announces Positive Results From a Study With A3309 in Patients With Chronic Constipation
Date:4/29/2010

GOTHENBURG, Sweden, April 29, 2010 /PRNewswire/ -- Albireo today announced that additional clinical data will be reported from a recent study assessing the safety, tolerability and efficacy of A3309 in patients with chronic constipation. A3309 is a first-in-class investigational compound for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic constipation (CC). The results will be presented during the 2010 Digestive Disease Week (DDW) annual meeting being held in New Orleans, US.

The presentation was selected as a "poster of distinction", meaning that the poster was in the top 10% of all AGA Institute abstracts selected for poster presentation. In addition, a poster presenting the preclinical A3309 data has been accepted.

    Details of the DDW session:

    Session Type: Poster Session
    Session Title: Constipation and IBS: Diagnosis and Treatment
    Session Date & Time: May 2, 2010 from 8:00 a.m. to 5:00 p.m.

    Title of the clinical abstract:
    The IBAT inhibitor A3309 - A Promising Treatment option for Patients with
    Chronic Idiopathic Constipation

    Title of the abstract describing preclinical findings:
    The IBAT inhibition by A3309 - A potential mechanism for the treatment of
    constipation

"The results show that A3309 was found to be safe and well tolerated and identified clear signs of improving colonic motility and bowel habits," said Magnus Simren, Principal Investigator (Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Sweden). "We are excited about the results of the trial, which confirms the potential that A3309 will benefit all those patients suffering from constipation and abdominal pain/discomfort who are refract
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SOURCE Albireo AB
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