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Alba Therapeutics Presents New Data for Larazotide Acetate at the 2008 American College of Gastroenterology Annual Scientific Meeting
Date:10/7/2008

the treatment of celiac disease and IBD.

The third poster presentation, "Relevance of the Gastrointestinal Symptom Rating Scale (GSRS) in Patients with Celiac Disease" (Poster 1023), includes results from a qualitative study conducted to investigate the validity of the GSRS in patients with celiac disease and to explore if the GSRS would constitute an appropriate and relevant scale to demonstrating the efficacy of novel treatments for celiac disease. Results showed that relevant subscales of the GSRS may be useful in clinical trials of novel treatments for celiac disease.

About Celiac Disease

Celiac disease (CD) is an inherited, lifelong T-cell mediated auto-immune disorder where the environmental trigger has been identified as gluten, which is found in wheat, barley, and rye. It is characterized by small intestinal inflammation and injury. CD is a growing public health concern, affecting approximately 3 million people in the United States and over 6.5 million people worldwide. The ingestion of gluten causes an immune response which triggers an inflammatory reaction in the small intestine. This then causes damage to the villi in the small intestine and can lead to total villous atrophy in CD. This results in varying symptoms such as fatigue, skin rash, anemia, fertility issues, stillborn births, joint pain, weight loss, pale sores inside the mouth, tooth discoloration or loss of enamel, depression, chronic diarrhea or constipation, and abdominal pain and bloating. The immunology and nutritional abnormalities in celiac disease can potentially result in long-term complications such as osteoporosis, refractory sprue, small intestinal cancer, and lymphoma. The only current management of CD is complete elimination of gluten from the diet, which can be very difficult to implement in practice.

About "Larazotide Acetate"

Larazotide acetate is an experimental medicine and an inhibitor of barrier dysfunction that has been shown to block abno
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