Navigation Links
Alba Therapeutics Presents New Data for Larazotide Acetate at the 2008 American College of Gastroenterology Annual Scientific Meeting
Date:10/7/2008

efficacy in inflammatory bowel disease targets and look forward to future research to uncover the product's potential in this important therapeutic area."

About the Studies

Results from CLIN 1001-004 were presented at ACG in a poster entitled "Larazotide Acetate Prevents Immunologic Changes Induced by Gluten Challenge in Celiac Disease Patients" (Poster 446). The randomized, double-blind, placebo-controlled study was designed to evaluate the effects of larazotide acetate on the systemic immunologic changes induced by a two week gluten challenge in patients with celiac disease. Study results showed that larazotide acetate was well tolerated and showed signs of efficacy in preventing immunologic changes induced by gluten challenge in patients with celiac disease, consistent with the beneficial effects observed on intestinal permeability, signs and symptoms. Clinical findings included:

-- Gluten challenge in the placebo (control) group resulted in an increase in circulating regulatory T cells (CD4, CD25, FOX-P3+) and a decrease in B cells (CD3, CD19+). These changes were completely prevented in the group on larazotide acetate.

-- There was a small, not statistically significant increase in the anti-tTG titer in the placebo (control) group, which was prevented in the group on larazotide acetate.

-- Other trends in specific monocyte populations induced by gluten challenge were also prevented to varying extents by larazotide acetate.

The second presentation, "Larazotide Acetate, a Tight Junction Inhibitor Peptide, Inhibits Epithelial Permeability Induced by TNF-alpha and IL-4" (Poster 1052) included results from a study investigating the effect of larazotide acetate on tumor necrosis factor (TNF-alpha) and interleukin (IL-4) induced permeability. The study showed that larazotide acetate inhibited increased permeability mediated with TNF-alpha and IL-4, which suggests the potential of larazotide acetate as a therapeutic agent for
'/>"/>

SOURCE Alba Therapeutics Corporation
Copyright©2008 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6

Related medicine technology :

1. In Vivo Data on Taligen Therapeutics Pipeline Candidates Presented at the XXII International Complement Workshop
2. BN ImmunoTherapeutics Announces Positive Mature Phase II Results From Newly Acquired Prostate Cancer Vaccine
3. Video: Sirion Therapeutics Launches Durezol for Postoperative Ocular Inflammation and Pain
4. Orexigen(R) Therapeutics Presents Data on Its Proprietary Formulation of Naltrexone Sustained Release (SR) Used in Contrave(R)
5. PTC Therapeutics Announces Data Showing Six-Minute Walk Test Consistently Measures Ambulatory Function in Patients With Duchenne Muscular Dystrophy
6. Data from In Vivo Disease Models on Taligen Therapeutics Pipeline Candidates to be Presented at the XXII International Complement Workshop
7. Data Confirm Synvista Therapeutics Haptoglobin Diagnostic Test Kit Success in Rapidly Determining Cardiovascular Risk in Patients with Diabetes
8. Logical Therapeutics Inc. Commences Double-Blind, Randomized Study of Their Lead Program, LT-NS001
9. Agile Therapeutics Achieves Phase 2 Study Endpoints in Key Clinical Trials with New, Innovative Low-Dose Contraceptive Patch
10. Tobira Therapeutics Inc. Receives US Patent for TBR-652
11. MabVax Therapeutics Closes Two Licensing Agreements With Sloan-Kettering Institute for Cancer Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2009)... Dec. 17 Frost & Sullivan ... American Healthcare Innovation Award in molecular diagnostics ... its commitment to providing innovative technologies for ... its incorporation in 2004, IntelligentMDx has introduced ... to make tests that are clinically impactful, ...
(Date:12/17/2009)... Mass., Dec. 17 Decision Resources, one ... focusing on pharmaceutical and healthcare issues, finds that ... there is a high need for diabetes drugs ... who say there is a high need for ... favor agents with excellent glucose lowering ability and ...
(Date:12/16/2009)... Dec. 17 Cell Therapeutics, Inc. ... that on February 10, 2010 the U.S. ... Committee (ODAC) will review the New Drug ... of relapsed/refractory aggressive non-Hodgkin,s lymphoma (NHL). ODAC ... evaluates data concerning the efficacy and safety ...
Breaking Medicine Technology:Frost & Sullivan Recognizes IntelligentMDx for Its Commitment to the Advancement of Healthcare and Diagnostics 2Frost & Sullivan Recognizes IntelligentMDx for Its Commitment to the Advancement of Healthcare and Diagnostics 3Frost & Sullivan Recognizes IntelligentMDx for Its Commitment to the Advancement of Healthcare and Diagnostics 4Frost & Sullivan Recognizes IntelligentMDx for Its Commitment to the Advancement of Healthcare and Diagnostics 5Over 70 Percent of Physicians Say There Is a High Need for More Diabetes Drugs with Novel Mechanisms of Action While 15 Percent Say the Same for DPP-IV Inhibitors 2Over 70 Percent of Physicians Say There Is a High Need for More Diabetes Drugs with Novel Mechanisms of Action While 15 Percent Say the Same for DPP-IV Inhibitors 3Cell Therapeutics Announces FDA's Oncologic Drugs Advisory Committee to Review Pixantrone for the Treatment of Relapsed/Refractory Aggressive Non-Hodgkin's Lymphoma, February 10, 2010 2Cell Therapeutics Announces FDA's Oncologic Drugs Advisory Committee to Review Pixantrone for the Treatment of Relapsed/Refractory Aggressive Non-Hodgkin's Lymphoma, February 10, 2010 3Cell Therapeutics Announces FDA's Oncologic Drugs Advisory Committee to Review Pixantrone for the Treatment of Relapsed/Refractory Aggressive Non-Hodgkin's Lymphoma, February 10, 2010 4Senator Proposes Use of Internet Gambling Revenue to Help Fund Health Care Reform 57860 1Senator Proposes Use of Internet Gambling Revenue to Help Fund Health Care Reform 57860 2New Report Highlights Proven Disease Prevention Programs in Communities 57858 1New Report Highlights Proven Disease Prevention Programs in Communities 57858 2New Report Highlights Proven Disease Prevention Programs in Communities 57858 3New Report Highlights Proven Disease Prevention Programs in Communities 57858 4MedImmune Receives U S Government Order for Additional 29 Million Doses of Nasal Spray Vaccine for 2009 H1N1 Influenza 57856 1MedImmune Receives U S Government Order for Additional 29 Million Doses of Nasal Spray Vaccine for 2009 H1N1 Influenza 57856 2MedImmune Receives U S Government Order for Additional 29 Million Doses of Nasal Spray Vaccine for 2009 H1N1 Influenza 57856 3
(Date:12/17/2009)... Jerusalem The Hebrew University of Jerusalem Kuvin ... Diseases has received a $5 million grant from ... into visceral leishmaniasis in Ethiopia. , The project ... vector biologist working at the Institute of Medical ... Medicine. , The project, entitled ,Studies on the ...
(Date:12/17/2009)... on our data, the molecular mechanism of infection employed ... Klemens Rottner, head of the HZI research group "Cytoskeleton ... the current issue of the scientific journal " Cellular ... bacteria. They can live in the presence and absence ... ingestion by humans occurs mainly via contaminated egg dishes ...
(Date:12/17/2009)... one day provide therapeutic options for muscle and bone ... the umbilical cord, just as the blood that goes ... disorders, said University of Pittsburgh School of Medicine researchers ... Journal of Biomedicine and Biotechnology . , Umbilical ... are remarkably stable and might not trigger strong immune ...
(Date:12/17/2009)... him a recluse at times, researcher says , , ... researcher claims he has identified the illness that ... nausea, vomiting, headaches and skin problems for most ... physical diagnoses have been suggested for the illness ... become a virtual recluse for periods of time. ...
(Date:12/17/2009)... the aging inequity , , THURSDAY, Dec. 17 ... gender inequity: Women develop more and deeper wrinkles ... do. , The disadvantage had long been suspected, ... said Dr. Foad Nahai, a plastic surgeon practicing ... Surgery Journal . The study appears in the ...
Breaking Medicine News(10 mins):Health News:Hebrew U. receives $5 million for research on leishmaniasis in Ethiopia 2Health News:Invasion without a stir 2Health News:Umbilical cord could be new source of plentiful stem cells, say Pitt researchers 2Health News:New Theory Emerges on Darwin's Illness 2Health News:Mouth Area Wrinkles More in Women Than Men 2Health News:Mouth Area Wrinkles More in Women Than Men 3
... charity Diabetes UK will be withdrawing diabetic food from ... //the disuse of diabetic food which they say are ... ,Squash drinks, chocolates, jam and marmalade specially made ... food stores and pharmacies from today. According to the ...
... have left its impact on the six million care givers in ... because of caring //. ,The survey revealed that only ... GP while 90% of them considered that they should be offered ... that their own health problems affected their ability to care. Besides ...
... as transcendental meditation may decrease blood pressure and ... heart disease, according to a report in the ... one of the JAMA/Archives journals. , ... in India, is taught through a standard protocol ...
... it is found that the survival rate of Hodgkin’s disease ... of the study were published in the journal Cancer. //It ... had the best prognosis. There were significant differences existed between ... malignancy of the lymphatic system of the body, which includes ...
... host a week-long meeting on the Codex Committee on ... , becoming the first Asian host for the meeting ... senior Thai official said. ,Dr. Charal Trinvuthipong, ... 350 delegates from 169 member countries of Codex would ...
... of diabetes has taken on alarming proportions in the last two ... loss of millions of lives, according to a recent study. // ... out that China has the largest number of people with diabetes ... over followed by India with with 30 million people affected by ...
Other Medicine News:Health News:Care Workers Need Some Care Too 2Health News:Meditation may Improve Cardiac Risk Factors in Patients with Coronary Heart Disease 2Health News:HD Type Plays an Important Role in the Survival of the Patient 2
... The BD Safety Knife with BD Xstar ... shield that protects the blade in prodedure ... is based on a grind-less process for ... yields outstanding sharpness and consistency. The ...
Electric high speed system....
The Durafuge 100 spins swing-out rotors at 4000 rpm and fixed-angle rotors at up to 6300 rpm....
Prevents formation of microscopic ice crystals and sample distortion caused by slow freezing of hyperosmolar tissue samples in conventional cyrostats....
Medicine Products: